Occurrence and removal of lidocaine, tramadol, venlafaxine, and their metabolites in German wastewater treatment plants

Rúa-Gómez, Paola C.; Püttmann, Wilhelm

doi:10.1007/s11356-011-0614-1

Cited by 115 publications

(48 citation statements)

References 21 publications

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“…Tramadol and lidocaine show chronic toxicity towards D. rerio, B. rerio [43]. Recent studies confirmed that cocaine present in aquatic environment is also toxic to aquatic organisms.…”

Section: Ecotoxicity Of Pharmaceuticalsmentioning

confidence: 90%

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Fate and Removal of Pharmaceuticals and Illegal Drugs Present in Drinking Water and Wastewater

Szymonik

Lach

Malińska

2017

Ecological Chemistry and Engineering S

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Rapid development of pharmaceutical industry, and thus widespread availability of different types of therapeutical and increased intake of pharmaceuticals, results in elevated concentrations of pharmaceuticals in municipal wastewater subjected to treatment in wastewater treatment plants. Pharmaceuticals present in raw wastewater discharged from hospitals, households, veterinary and health care clinics eventually end up in wastewater treatment plants. Commonly applied methods for treating wastewater do not allow complete removal of these contaminants. As a consequence, pharmaceuticals still present in treated wastewater are introduced to water environment. The most frequently identified pharmaceuticals in surface water belong to the following groups: non steroidal anti inflammatory drugs, beta-blockers, estrogens and lipid regulators. The most difficult is removal of diclofenac, clofibric acid and carbamazepine as these substances show low biodegradability. Diclofenac can be removed in the process of wastewater treatment by 40%, carbamazepine by 10%, and clofibric acid from 26 to 50%. The presence of diclofenac sodium in the rivers in Poland was confirmed and the concentrations were following: 380 ng/dm 3 (the Warta river), 470 ng/dm 3 (the Odra river), 140 ng/dm 3 (the Vistula river). Naproxene was found in the Warta river at the concentration of 100 ng/dm 3 . The presence of pharmaceuticals in surface water can be toxic to aqueous microorganisms and fish. Recent studies confirmed also the presence of pharmaceuticals in drinking water. This is considered as a problem especially in urban agglomerations such as Berlin or large cities in Spain and China. The studies showed that pharmaceuticals were also identified in the samples taken from the Polish rivers and drinking water. The presence of naproxene and diclofenac at the concentrations of 13 and 4 ng/dm 3 was identified in drinking water sampled from water intakes in Poznan. Surface water and drinking water showed also the presence of illegal drugs.

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“…Tramadol and lidocaine show chronic toxicity towards D. rerio, B. rerio [43]. Recent studies confirmed that cocaine present in aquatic environment is also toxic to aquatic organisms.…”

Section: Ecotoxicity Of Pharmaceuticalsmentioning

confidence: 90%

“…These drugs are easily soluble and susceptible to adsorption on activated sludge. The removal of tramadol and lidocaine from wastewater is about 40% [43].…”

Section: Other Pharmaceuticalsmentioning

confidence: 99%

Fate and Removal of Pharmaceuticals and Illegal Drugs Present in Drinking Water and Wastewater

Szymonik

Lach

Malińska

2017

Ecological Chemistry and Engineering S

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“…The occurrence of VFA and its metabolites in surface waters [11] indicates the improper elimination in WWTPs and their extreme adverse effects underlines the need for their degradation prior to their discharge, with AOPs able to play the last, polishing step [41]. Table 4 summarizes literature values and own measurements of VFA in WWTPs, at various stages, from influents to effluents.…”

Section: Experiments In Real Secondary Wastewater Effluents and Humanmentioning

confidence: 99%

“…Chemically, it belongs to the class of benzene and substituted derivatives and is a tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-methoxyphenyl group (Table 1). Its excretion from the body follows the renal route, ends up in WWTPs, and therefore it is found in natural waters as VFA, plus its metabolites are escaping in almost 50% rate the wastewater treatment process [9][10][11][12]. Measured concentrations range from 18 to 122 ng L À1 for VFA [13], or 102 and 690 ng L À1 [11,14] which could affect the natural biota.…”

Section: Introductionmentioning

confidence: 99%

Solar photo-Fenton and UV/H 2 O 2 processes against the antidepressant Venlafaxine in urban wastewaters and human urine. Intermediates formation and biodegradability assessment

Giannakis

Hendaoui

Jović

et al. 2017

Chemical Engineering Journal

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“…Lidocaine is widely used as a local anaesthetic and anti-arrhythmic agent for cardiac disorders. [62] Fentanyl, an opioid, is a narcotic analgesic used as a surgical anaesthetic and for the treatment of pain in cancer patients. [58,61,63] The main metabolite of fentanyl is norfentanyl (Table 9).…”

Section: Chemicalmentioning

confidence: 99%

Neuropsychiatric pharmaceuticals and illicit drugs in wastewater treatment plants: a review

Asimakopoulos

Kannan

2016

Environ. Chem.

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Environmental context. Neuropsychiatric pharmaceuticals and illicit drugs in wastewaters are of increasing environmental concern. We compile the recent literature and evaluate the concentrations and profiles of various drugs and their removal efficiencies in wastewater treatment plants. The sewage epidemiology approach, used in the estimation of drug usage in communities, is discussed, and we make recommendations for future research in this area.Abstract. Neuropsychiatric pharmaceuticals and illicit drugs encompass a broad range of compounds including opioids, amphetamine-type stimulants, cannabinoids, benzodiazepines, barbiturates, antipsychotics, anaesthetics, anti-epileptics and mood stabilisers, lysergic compounds, sympathomimetic amines and cocaine derivatives. In this article, we review studies on the occurrence and fate of these drugs in wastewater treatment plants. In general, among various drugs studied, the concentrations and detection frequencies of opioids and cocaine derivatives were the highest in wastewaters. The forensic analysis of wastewaters suggests that cocaine and opioids usage has increased. Given the fact that data on drug usage can be used for making regulatory decisions and policies, this review focuses on understanding the sources and environmental dynamics of neuropsychiatric and illicit drugs. There is a pressing need for more research on the magnitude and extent of illicit drug consumption. The 'sewage epidemiology' approach, currently applied in the estimation of illicit drug consumption in communities, is reviewed. The field of wastewater research has been advancing in multipronged paths, incorporating concepts in analytical chemistry, organic chemistry, environmental chemistry, biochemistry, sewage engineering, drug epidemiology and statistics. Future prospects with regard to the occurrence and environmental fate of illicit and psychoactive drugs are recommended.

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Occurrence and removal of lidocaine, tramadol, venlafaxine, and their metabolites in German wastewater treatment plants

Abstract: LDC, TRA, VEN, ODT, and ODV are only partially removed from sewage water by WWTPs and thus are continuously discharged in respective recipient rivers. A further transformation of TRA and VEN into the known metabolites during treatment in the WWTPs is not observed.

Cited by 115 publications

References 21 publications

Fate and Removal of Pharmaceuticals and Illegal Drugs Present in Drinking Water and Wastewater

Fate and Removal of Pharmaceuticals and Illegal Drugs Present in Drinking Water and Wastewater

Solar photo-Fenton and UV/H 2 O 2 processes against the antidepressant Venlafaxine in urban wastewaters and human urine. Intermediates formation and biodegradability assessment

Neuropsychiatric pharmaceuticals and illicit drugs in wastewater treatment plants: a review

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