Occurrence and removal of multiple classes of antibiotics and antimicrobial agents in biological wastewater treatment processes

Trần, Ngọc Hân; Chen, Hongjie; Reinhard, Martin; Mao, Feijian; Gin, Karina Yew‐Hoong

doi:10.1016/j.watres.2016.08.040

Cited by 357 publications

(99 citation statements)

References 64 publications

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“…Over the course of the sampling period, spikes in vancomycin use did not coincide with spikes in the abundance of VRE in the PE or FEs of WWTPs. The rate at which an antimicrobial is metabolized by humans and animals (or in wastewater) can differ depending on a variety of factors including the class of antimicrobial and the wastewater treatment process [69]. While concentrations of antimicrobial residues in hospital or retirement home effluent can be high, the downstream effluent concentrations are often low, making it likely that their contribution to selective pressure for multi-drug resistant enterococci is low [49].…”

Section: Discussionmentioning

confidence: 99%

Quantification and Multidrug Resistance Profiles of Vancomycin-Resistant Enterococci Isolated from Two Wastewater Treatment Plants in the Same Municipality

et al. 2019

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Wastewater treatment plants (WWTPs) are points of control for the environmental dissemination of antimicrobial resistant bacteria. Vancomycin-resistant enterococci (VRE) were used as indicators of antimicrobial resistance (AMR) in two WWTPs (biologically aerated filter (BAF) and conventional activated sludge (CAS)) in the same municipality. The removal and abundance of enterococci and VRE as well as the species and antimicrobial resistance profiles of VRE were assessed. Enterococci and VRE from the primary and final effluents were enumerated. Results were assessed from an ecological context. VRE was not selected for by either WWTP but the BAF system outperformed the CAS system for the removal of enterococci/VRE. Enterococcus faecalis (n = 151), E. faecium (n = 94) and E. casseliflavus/E. gallinarum (n = 59) were the dominant VRE species isolated. A decrease in levofloxacin resistance in enterococci was observed in the BAF WWTP. An increase in nitrofurantoin resistant (p < 0.001) and a decrease in quinupristin/dalfopristin (p = 0.003) and streptomycin (p = 0.022) resistant enterococci were observed in the CAS WWTP, corresponding to a shift of VRE from E. faecalis to E. faecium. Wastewater treatment processes can be managed to limit the dissemination of antimicrobial resistance determinants into the surrounding environment.

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Section: Discussionmentioning

confidence: 99%

Quantification and Multidrug Resistance Profiles of Vancomycin-Resistant Enterococci Isolated from Two Wastewater Treatment Plants in the Same Municipality

et al. 2019

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“…These substances have high log K ow values, thereby indicating that they are more hydrophobic than the other substances. Tran et al (2016) reported that adsorption occurs between the positively charged dimethylamino group and the negatively charged sludge surface [39]. The waste sludge mass load was 58 g/d in STP A, 48 g/d in STP B, 25 g/d in STP C, and 19 g/d in STP D, with 80% or more contained in the solid phase.…”

Section: Mass Loads Of Pharmaceuticals In Each Treatment Processmentioning

confidence: 99%

Distribution and Removal of Pharmaceuticals in Liquid and Solid Phases in the Unit Processes of Sewage Treatment Plants

Park

Kim

Hong³

et al. 2020

IJERPH

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In this study, we analyzed 27 pharmaceuticals in liquid and solid phase samples collected from the unit processes of four different sewage treatment plants (STPs) to evaluate their distribution and behavior of the pharmaceuticals. The examination of the relative distributions of various categories of pharmaceuticals in the influent showed that non-steroidal anti-inflammatory drugs (NSAIDs) were the most dominant. While the relative distribution of antibiotics in the influent was not high (i.e., 3%–5%), it increased to 14%–30% in the effluent. In the four STPs, the mass load of the target pharmaceuticals was reduced by 88%–95% mainly in the biological treatment process, whereas the ratio of pharmaceuticals in waste sludge to those in the influent (w/w) was only 2%. In all the STPs, the removal efficiencies for the stimulant caffeine, NSAIDs (acetaminophen, naproxen, and acetylsalicylic acid), and the antibiotic cefradine were high; they were removed mainly by biological processes. Certain compounds, such as the NSAID ketoprofen, contrast agent iopromide, lipid regulator gemfibrozil, and antibiotic sulfamethoxazole, showed varying removal efficiencies depending on the contribution of biodegradation and sludge sorption. In addition, a quantitative meta-analysis was performed to compare the pharmaceutical removal efficiencies of the biological treatment processes in the four STPs, which were a membrane bioreactor (MBR) process, sequencing batch reactor (SBR) process, anaerobic–anoxic–oxic (A2O) process, and moving-bed biofilm reactor (MBBR) process. Among the biological processes, the removal efficiency was in the order of MBR > SBR > A2O > MBBR. Among the tertiary treatment processes investigated, powdered activated carbon showed the highest removal efficiency of 18%–63% for gemfibrozil, ibuprofen, ketoprofen, atenolol, cimetidine, and trimethoprim.

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“…Currently, there are various practices and methods of monitoring AMR dissemination and the fate of ARB and ARGs in aquatic environmental systems. Highly sensitive analytical protocols have been developed to detect antimicrobials using liquid chromatography-tandem mass spectrometry in environmental water samples and effluents from wastewater treatment plants (WWTPs) [7,8], while culture-based techniques are used to enumerate ARB.…”

Section: Antimicrobialsmentioning

confidence: 99%

Monitoring Antimicrobial Resistance Dissemination in Aquatic Systems

Gin

2019

Water

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This special issue on Antimicrobial Resistance in Environmental Waters features 11 articles on monitoring and surveillance of antimicrobial resistance (AMR) in natural aquatic systems (reservoirs, rivers), and effluent discharge from water treatment plants to assess the effectiveness of AMR removal and resulting loads in treated waters. The occurrence and distribution of antimicrobials, antibiotic resistant bacteria (ARB), antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) was determined by utilizing a variety of techniques including liquid chromatography—mass spectrometry in tandem (LC-MS/MS), traditional culturing, antibiotic susceptibility testing (AST), molecular and OMIC approaches. Some of the key elements of AMR studies presented in this special issue highlight the underlying drivers of AMR contamination in the environment and evaluation of the hazard imposed on aquatic organisms in receiving environments through ecological risk assessments. As described in this issue, screening antimicrobial peptide (AMP) libraries for biofilm disruption and antimicrobial candidates are promising avenues for the development of new treatment options to eradicate resistance. This editorial puts into perspective the current AMR problem in the environment and potential new methods which could be applied to surveillance and monitoring efforts.

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Occurrence and removal of multiple classes of antibiotics and antimicrobial agents in biological wastewater treatment processes

Cited by 357 publications

References 64 publications

Quantification and Multidrug Resistance Profiles of Vancomycin-Resistant Enterococci Isolated from Two Wastewater Treatment Plants in the Same Municipality

Quantification and Multidrug Resistance Profiles of Vancomycin-Resistant Enterococci Isolated from Two Wastewater Treatment Plants in the Same Municipality

Distribution and Removal of Pharmaceuticals in Liquid and Solid Phases in the Unit Processes of Sewage Treatment Plants

Monitoring Antimicrobial Resistance Dissemination in Aquatic Systems

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