Occurrence and significance of folic acid

Cieśłik, Ewa; Cieślik, Iwona

doi:10.1515/pteridines-2018-0017

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…Pteroyl-D-glutamic acid, the active metabolite of folic acid [ 21 ], is essential to prevent congenital malformations such as neural tube defects [ 22 ]. Folic acid and its derivatives are present in meat products (chicken liver), leafy green vegetables (spinach, parsley), grains (green beans, peas, chickpeas), and fruits (apple, orange, strawberry), with concentrations ranging from 1 to 580 µg of folate/100 g fresh weight [ 23 , 24 ]. Due to processing, a significant decrease in pteroyl-D-glutamic acid was observed in strawberries.…”

Section: Discussionmentioning

confidence: 99%

Untargeted Metabolomics Reveals New Markers of Food Processing for Strawberry and Apple Purees

et al. 2022

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In general, food processing and its conditions affect nutrients, bioactive compounds, and sensory characteristics of food products. This research aims to use a non-targeted metabolomics approach based on UPLC-ESI-QTOF-MS to determine how fruit processing can affect the metabolic profile of fruits and, through a comprehensive metabolic analysis, identify possible markers to assess their degree of processing. The present study uses a real case from the food industry to evaluate markers of the processing of strawberry and apple purees industrially elaborated with different processing techniques and conditions. The results from the multivariate analysis revealed that samples were grouped according to the type of processing, evidencing changes in their metabolic profiles and an apparent temperature-dependent effect. These metabolic profiles showed changes according to the relevance of thermal conditions but also according to the exclusively cold treatment, in the case of strawberry puree, and the pressure treatment, in the case of apple puree. After data analysis, seven metabolites were identified and proposed as processing markers: pyroglutamic acid, pteroyl-D-glutamic acid, 2-hydroxy-5-methoxy benzoic acid, and 2-hydroxybenzoic acid β-d-glucoside in strawberry and di-hydroxycinnamic acid glucuronide, caffeic acid and lysoPE(18:3(9Z,12Z,15Z)/0:0) in apple purees. The use of these markers may potentially help to objectively measure the degree of food processing and help to clarify the controversial narrative on ultra-processed foods.

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Section: Discussionmentioning

confidence: 99%

Untargeted Metabolomics Reveals New Markers of Food Processing for Strawberry and Apple Purees

et al. 2022

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“…The stability decreases when exposed to or influenced by pH, temperature, light, oxidizing, alkaline media or strong acidic, oxygen, moisture, and reducing agents. When considering thermal degradation, a process more prone to occur in fortified salt, FA undergoes degradation, resulting in the formation of glutamic and pteroic acid [1,2,3,4,5,6].…”

Section: Introduction 1folatementioning

confidence: 99%

A Review of Microfiltration Membrane in Separating Folic Acid from Fermented Dark Green Leafy Vegetables (DGLVs), Legumes, Beans, and Cereal for Nutraceutical Application

Susilowati,

Melanie

et al. 2023

ijmst

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DGLVs (spinach, broccoli), legumes (soybean, mung bean, kidney bean), and cereal (corn) are well recognized for human health benefits due to the presence of natural folate (vitamin B9) with essential micronutrients. Folate is among the most unstable vitamins for the normal functions of the human body. The recent development of membrane-based methods for the separation of folic acid (FA) is reviewed from the selected literature and covers the result of significant research that has been performed in the last five years on the use of the microfiltration (MF) method. This is coupled with the fermentation process to support and achieve separation or recovery of FA from their selected plant-based food source. The nixtamalization, fermentation, separation, and purification of DGLVs, legumes, and beans, as well as corn, were conducted using the MF (pore size 0.15 µm) membrane separation method. The results showed that the MF membrane was able to separate FA components in permeate from fermented spinach and broccoli, soybean, mung bean, kidney bean, and corn, namely 7.14 and 3.79, 197.00, 325.37 and 242.93, and 121.10 µg/mL, respectively. Meanwhile, FA content in retentate from fermented spinach and broccoli, soybean, mung bean, kidney bean, and corn was 58.90 and 28.10, 362.07, 254.07 and 506.07, and 212.84 µg/mL, respectively. The applications of membrane techniques were used as an alternative to some unit operations in the solving of separation issues as well as the development of selected new fermented plant-based food sources. The contemporary pressure-driven membranes, such as MF, and the main applications were related to pre-treatment, selected fermented plant-based food sources, and alternative technology for extending the shelf life of natural folate. The utilization of MF membranes in the nutraceutical field holds significant promise, particularly in the creation of value-added products from minor compounds.

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“…FA reduces homocysteine levels in the blood. In the 1930s-1940s, Lucy Willis, a physician, discovered FA supplements after conducting anemia-based tests among women in India [ 1 ]. Spina bifida is particularly common in the Kingdom of Saudi Arabia (KSA), affecting 1.2 in 1000 people [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Attitude and Practice of Folic Acid Consumption Among Saudi Pregnant Women at Yanbu City, Kingdom of Saudi Arabia

Al-Marwani¹,

Al-Zahrani²

2022

Cureus

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BackgroundFolic acid (FA) intake is important for pregnant women for the healthy growth and development of their babies. It is well known that the intake of FA before and during pregnancy help in reducing the risks of congenital anomalies. MethodsA quantitative cross-sectional design was used to assess pregnant women's attitudes and practices related to FA. This study was conducted in the Antenatal Clinic at Yanbu General Hospital from February 2021 to May 2021. Structured questionnaires were used for data collection from a sample of pregnant women (n=65). ResultsThe study revealed that less than half of the study sample consumed FA daily and only 46.2% of women started consuming FA during the first month of pregnancy. ConclusionAction should be taken by the Saudi Health Organization for empowering child-bearing women to consume adequate sources of FA at the appropriate time and frequency.

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Occurrence and significance of folic acid

Cited by 7 publications

References 15 publications

Untargeted Metabolomics Reveals New Markers of Food Processing for Strawberry and Apple Purees

Untargeted Metabolomics Reveals New Markers of Food Processing for Strawberry and Apple Purees

A Review of Microfiltration Membrane in Separating Folic Acid from Fermented Dark Green Leafy Vegetables (DGLVs), Legumes, Beans, and Cereal for Nutraceutical Application

Attitude and Practice of Folic Acid Consumption Among Saudi Pregnant Women at Yanbu City, Kingdom of Saudi Arabia

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