Occurrence, chemical composition, biological activities and analytical methods on Copaifera genus—A review

Arruda, Caroline; Mejía, Jennyfer Andrea Aldana; Ribeiro, Victor Pena; Borges, Carly Henrique Gambeta; Martins, Carlos Henrique Gomes; Veneziani, Rodrigo Cássio Sola; Ambrósio, Sérgio Ricardo; Bastos, Jairo Kenupp

doi:10.1016/j.biopha.2018.10.030

Cited by 82 publications

(81 citation statements)

References 129 publications

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“…In the present study, the major compounds present in the C. reticulata oleoresin were γ‐macrocarpene (14.2%), α‐bergamotene (13.6%), β‐selinene (13.4%) and β‐caryophyllene (11.7%), similar to the compositions reported in the literature (Arruda et al, 2019; Costa et al, 2017; Trindade et al, 2018). Despite the high presence of these compounds in the C. reticulata oleoresins, biological activities of the oleoresins may be synergistic or additive rather than being caused by individual compounds (Arruda et al, 2019).…”

Section: Discussionsupporting

confidence: 90%

“…Oleoresins of Copaifera spp. generally have a complex chemical composition, and they vary between species regarding the presence and abundance of each chemical compound (Arruda et al, 2019; Veiga & Pinto, 2002). Nevertheless, these oleoresins are composed mostly of sesquiterpenes such as caryophyllene, copaene and humulene, and they interact with different target proteins in parasites (Arruda et al, 2019; Costa et al, 2017; Trindade et al, 2018; Veiga & Pinto, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…generally have a complex chemical composition, and they vary between species regarding the presence and abundance of each chemical compound (Arruda et al, 2019; Veiga & Pinto, 2002). Nevertheless, these oleoresins are composed mostly of sesquiterpenes such as caryophyllene, copaene and humulene, and they interact with different target proteins in parasites (Arruda et al, 2019; Costa et al, 2017; Trindade et al, 2018; Veiga & Pinto, 2002). In the present study, the major compounds present in the C. reticulata oleoresin were γ‐macrocarpene (14.2%), α‐bergamotene (13.6%), β‐selinene (13.4%) and β‐caryophyllene (11.7%), similar to the compositions reported in the literature (Arruda et al, 2019; Costa et al, 2017; Trindade et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, these oleoresins are composed mostly of sesquiterpenes such as caryophyllene, copaene and humulene, and they interact with different target proteins in parasites (Arruda et al, 2019; Costa et al, 2017; Trindade et al, 2018; Veiga & Pinto, 2002). In the present study, the major compounds present in the C. reticulata oleoresin were γ‐macrocarpene (14.2%), α‐bergamotene (13.6%), β‐selinene (13.4%) and β‐caryophyllene (11.7%), similar to the compositions reported in the literature (Arruda et al, 2019; Costa et al, 2017; Trindade et al, 2018). Despite the high presence of these compounds in the C. reticulata oleoresins, biological activities of the oleoresins may be synergistic or additive rather than being caused by individual compounds (Arruda et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…These compounds have shown biological activity in Copaifera spp. (Arruda et al, 2019; Trindade, Silva, & Setzer, 2018), including anthelmintic activity against monogeneans in fish (Costa et al, 2017; Valentim et al, 2018b). Hence, there exists a growing interest in the use of oleoresins and essential oils and their bioactive compounds for treating fish infected by monogeneans (Luis et al, 2019; Morales‐Serna et al, 2019; Tavares‐Dias, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Nanoemulsions with oleoresin of Copaifera reticulata (Leguminosae) improve anthelmintic efficacy in the control of monogenean parasites when compared to oleoresin without nanoformulation

Malheiros

Sarquis

Ferreira

et al. 2020

Journal of Fish Diseases

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This study compared the in vitro anthelmintic activity of Copaifera reticulata oleoresin (200, 400, 600, 800 and 1,000 mg/L) and of nanoemulsions prepared with this oleoresin (50, 100, 150, 200 and 250 mg/L) against monogeneans on the gills of Colossoma macropomum. The major compounds present in the oleoresin of C. reticulata were γ‐macrocarpene (14.2%), α‐bergamotene (13.6%), β‐selinene (13.4%) and β‐caryophyllene (11.7%). All concentrations of the nanoemulsion and the oleoresin without nanoformulation showed anthelmintic efficacy against monogeneans, and higher concentrations led to more rapid parasite mortality. Structural damages to the tegument of the parasites exposed to C. reticulata oleoresin were observed with scanning electron microscopy. At two hours of exposure, fish showed 100% tolerance to all nanoemulsion concentrations used in the in vitro assays, whereas 100% mortality was shown in the fish exposed to the oleoresin without nanoformulation after one hour. The results of this study suggest that nanoemulsions with oleoresin of C. reticulata have advantages in the control and treatment of monogenean infections in C. macropomum when compared to the oleoresin without nanoformulation. In addition, since nanoemulsions with the C. reticulata oleoresin are safe to control monogeneans, the efficacy of these nanoformulations may be assayed in therapeutic baths to treat C. macropomum infected by monogeneans.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nanoemulsions with oleoresin of Copaifera reticulata (Leguminosae) improve anthelmintic efficacy in the control of monogenean parasites when compared to oleoresin without nanoformulation

Malheiros

Sarquis

Ferreira

et al. 2020

Journal of Fish Diseases

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Molecular distillation of copaiba oleoresin—A clean process for diterpenes enrichment

et al. 2022

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Copaiba oleoresin has sesquiterpenes and diterpenes with significant medicinal properties, including being antimicrobial, antiparasitic, and wound healing, among others. Thus, the objective of this work was to study the diterpene enrichment of the copaiba oleoresin from Copaifera officinalis via molecular distillation. Evaporator temperature (EVT) and feed flow rate (Q) were evaluated using an experimental design (2 2 with central point) considering the ratio of distillate and residue streams (DTR) as the response to optimize the residue recovery. EVT and Q were the main effects for diterpenes recovery, with the best experimental condition at 100 C (EVT) and 15 ml/min (Q) under 0.001 mbar, of which the residue stream had a diterpenes content of 99.25%. With the molecular distillation process, it was possible to add value to the copaiba streams, separating and purifying diterpenes with applicability in the biomedical and pharmaceutical industries since no solvent is used in this process (clean).

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Dietary Diterpenoids

Asakawa

Kenmoku

2021

Handbook of Dietary Phytochemicals

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A number of foods, vegetables, fruits, and beverages (tea, coffee, and liqueur) contain many kinds of diterpenoids (mainly abietanes, cembranes, clerodanes, cyatanes, dolabellanes, fusicoccanes, kauranes, labdanes, pimaranes, taxanes, trachilobanes, totaranes) and their related compounds. This chapter summarizes the distribution of diterpenoids in dietary foods, vegetables, fruits, beverages, and processed foods, and their biological and pharmacological activity, effects, and application to our health, as well as metabolic pathways of several diterpenoids, which are widely distributed in dietary foods, by microorganisms and mammals.

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Occurrence, chemical composition, biological activities and analytical methods on Copaifera genus—A review

Cited by 82 publications

References 129 publications

Nanoemulsions with oleoresin of Copaifera reticulata (Leguminosae) improve anthelmintic efficacy in the control of monogenean parasites when compared to oleoresin without nanoformulation

Nanoemulsions with oleoresin of Copaifera reticulata (Leguminosae) improve anthelmintic efficacy in the control of monogenean parasites when compared to oleoresin without nanoformulation

Molecular distillation of copaiba oleoresin—A clean process for diterpenes enrichment

Dietary Diterpenoids

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