Occurrence, Distribution, and Ecological Risk of Fluoroquinolones in Rivers and Wastewaters

Teglia, Carla M.; Perez, Florencia A.; Michlig, Nicolás; Repetti, María Rosa; Goicoechea, Héctor C.; Culzoni, María J.

doi:10.1002/etc.4532

Cited by 65 publications

(23 citation statements)

References 53 publications

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“…A total of 20 antibacterial agents belonging to 8 groups (aminoglycosides, β-lactams, chloramphenicols, macrolides, nitrofurans, quinolones, sulfonamides, and tetracyclines) were used in 1996–2013, among them 12 compounds were not authorized. Teglia et al [ 21 ] observed 0.97–22.1 µg/L of various fluoroquinolone antibiotics (ciprofloxacin, enrofloxacin, ofloxacin, enoxacin, and difloxacin) in farm wastewaters of various regions in Argentina. Gbylik-Sikorska et al [ 22 ] investigated the occurrence of commonly used veterinary antibacterial agents in 159 fresh water, 443 fish, and 150 sediment samples from Polish rivers and lakes.…”

Section: The Presence Of Antibacterials In Aquatic Environmentmentioning

confidence: 99%

Antibacterials in Aquatic Environment and Their Toxicity to Fish

2020

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Antibacterial agents are commonly present in aquatic environment at low concentrations. Terrestrial animal farms, human medicine and aquaculture are main sources of water contamination with antibacterials. Antibiotics were proved to be directly toxic to fish causing oxidative stress, general stress response, histopathological lesions, hematological, metabolic, and reproductive disorders, as well as immunosuppressive and genotoxic effects. Environmentally realistic low concentrations of antibiotics also disturb aquatic bacterial communities causing alterations in fish symbiotic microbiota and induce emergence of antibiotic-resistant pathogenic bacteria by exerting selective pressure on spread of antibiotic-resistance genes.

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Section: The Presence Of Antibacterials In Aquatic Environmentmentioning

confidence: 99%

Antibacterials in Aquatic Environment and Their Toxicity to Fish

2020

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“…Since the 1980s and 1990s, fluoroquinolones were the antibiotics of choice for UTI treatment in Europe and North America (46). However, up to 62% of administered fluoroquinolones are excreted nonmetabolized in urine (47), and as a result, these antibiotics are an emerging pollutant of water and soil environments (48), with high environmental concentrations promoting the evolution of resistant forms. In E. coli, resistance to fluoroquinolones arises due to the presence of point mutations in gyrA and parC (49), first observed in the 1980s when these antibiotics were prescribed heavily in human and veterinary medicine.…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Account of Escherichia coli Sequence Type 131 in Wastewater Reveals an Abundance of Fluoroquinolone-Resistant Clade A Strains

Finn

Scriver

Lam

et al. 2020

Appl Environ Microbiol

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In the ten years since its discovery, the Escherichia coli clone sequence type 131 (ST131) has become a major international health threat, with the multidrug-resistant and extended-spectrum β-lactamase (ESBL)-producing clade C emerging as the globally dominant form. ST131 has previously been isolated from wastewater; however, most of these studies selectively screened for ESBL-producing organisms, thereby missing the majority of remaining ST131 clades. In this study, we used a high-throughput PCR-based screening strategy to comprehensively examine wastewater for the presence of ST131 over a 1-year period. Additional multiplex PCRs were used to differentiate clades and obtain an unbiased account of the total ST131 population structure within the collection. Furthermore, antimicrobial susceptibility profiles of all ST131-positive samples were tested against a range of commonly used antibiotics. From a total of over 3,762 E. coli wastewater samples, 1.86% (n = 70) tested positive for ST131, with the majority being clade A isolates. In total, 63% (n = 44) were clade A, 29% (n = 20) were clade B, 1% (n = 1) were clade C0, 6% (n = 4) were clade C1, and 1% (n = 1) were clade C2. In addition, a very high rate of resistance to commonly used antibiotics among wastewater isolates is reported, with 72.7% (n = 32) of clade A resistant to ciprofloxacin and high rates of resistance to gentamicin, sulfamethoxazole-trimethoprim, and tetracycline in clades that are typically sensitive to antibiotics. IMPORTANCE ST131 is a global pathogen. This clone causes urinary tract infections and is frequently isolated from human sources. However, little is known about ST131 from environmental sources. With the widely reported increase in antibiotic concentrations found in wastewater, there is additional selection pressure for the emergence of antibiotic-resistant ST131 in this niche. The unbiased screening approach reported herein revealed that previously antibiotic-sensitive lineages of ST131 are now resistant to commonly used antibiotics present in wastewater systems and may be capable of surviving UV sterilization. This is the most comprehensive account of ST131 in the wastewater niche to date and an important step in better understanding the ecology of this global pathogen.

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“…Currently, antimicrobials are being produced on a significant scale, are widely used in both human and veterinary medicine, livestock production and agriculture, and consequently are released in the environment in unnatural amounts, becoming an important and emerging contaminant [23]. Sewage waters from urban areas, hospitals, and animal farm effluents may be delivered into rivers and the environment, increasing the environmental contamination by antimicrobials, and unbalancing their natural concentration in ecosystems [24,25]. Consequently, both human and environmental bacteria can be under the selective pressure of different antibiotic concentrations and gradients.…”

Section: Introductionmentioning

confidence: 99%

Metagenomics and Other Omics Approaches to Bacterial Communities and Antimicrobial Resistance Assessment in Aquacultures

Nogueira

Botelho

2021

Antibiotics

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The shortage of wild fishery resources and the rising demand for human nutrition has driven a great expansion in aquaculture during the last decades in terms of production and economic value. As such, sustainable aquaculture production is one of the main priorities of the European Union’s 2030 agenda. However, the intensification of seafood farming has resulted in higher risks of disease outbreaks and in the increased use of antimicrobials to control them. The selective pressure exerted by these drugs provides the ideal conditions for the emergence of antimicrobial resistance hotspots in aquaculture facilities. Omics technology is an umbrella term for modern technologies such as genomics, metagenomics, transcriptomics, proteomics, culturomics, and metabolomics. These techniques have received increasing recognition because of their potential to unravel novel mechanisms in biological science. Metagenomics allows the study of genomes in microbial communities contained within a certain environment. The potential uses of metagenomics in aquaculture environments include the study of microbial diversity, microbial functions, and antibiotic resistance genes. A snapshot of these high throughput technologies applied to microbial diversity and antimicrobial resistance studies in aquacultures will be presented in this review.

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Occurrence, Distribution, and Ecological Risk of Fluoroquinolones in Rivers and Wastewaters

Cited by 65 publications

References 53 publications

Antibacterials in Aquatic Environment and Their Toxicity to Fish

Antibacterials in Aquatic Environment and Their Toxicity to Fish

A Comprehensive Account of Escherichia coli Sequence Type 131 in Wastewater Reveals an Abundance of Fluoroquinolone-Resistant Clade A Strains

Metagenomics and Other Omics Approaches to Bacterial Communities and Antimicrobial Resistance Assessment in Aquacultures

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