Occurrence, fate and removal of synthetic oral contraceptives (SOCs) in the natural environment: A review

Liu, Ze‐hua; Ogejo, Jactone Arogo; Pruden, Amy; Knowlton, Katharine F.

doi:10.1016/j.scitotenv.2011.08.047

Cited by 93 publications

(57 citation statements)

References 145 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, compared to estrogens, the occurrence, fate and effects of progestins were poorly studied. They are found in effluents and in surface waters (rivers, lakes, streams) and ground waters at concentrations up to tens of ng/L, but also in sediments from rivers at concentrations up to tens of ng/g (for review see (Besse and Garric 2009, Liu et al 2011, Fent 2015. Moreover, progestins are potent developmental and reproductive toxicants for aquatic organisms (for review see Zeilinger et al 2009, Kumar et al 2015.…”

Section: Introductionmentioning

confidence: 99%

“…Among these progestins, levonorgestrel (LNG) is a synthetic progestin structurally related to testosterone (19-Nortestosterone derivative), used alone or in association with an estrogen such as ethinylestradiol for contraception purposes (emergency contraceptives or birth control pills). LNG has been detected in some effluents, sediments, ground water, tap water, but also in surface water of rivers at concentrations up to 38 ng/L (Vulliet et al 2008, Besse and Garric 2009, Al-Odaini et al 2010, Liu et al 2011, Vulliet and Cren-Olivé 2011, Fent 2015. LNG exerts biological activities that differ from the natural progestin (progesterone) since it has progestagenic and androgenic activities (Besse and Garric 2009) and also estrogenic activities both in vitro and in vivo (Jeng et al 1992, Zucchi et al 2012, Creusot et al 2014, Kroupova et al 2014.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Additive effects of levonorgestrel and ethinylestradiol on brain aromatase ( cyp19a1b ) in zebrafish specific in vitro and in vivo bioassays

Hinfray¹,

Tebby

Garoche³

et al. 2016

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

Estrogens and progestins are widely used in combination in human medicine and both are present in aquatic environment. Despite the joint exposure of aquatic wildlife to estrogens and progestins, very little information is available on their combined effects. In the present study we investigated the effect of ethinylestradiol (EE2) and Levonorgestrel (LNG), alone and in mixtures, on the expression of the brain specific ER-regulated cyp19a1b gene. For that purpose, recently established zebrafish-derived tools were used: (i) an in vitro transient reporter gene assay in a human glial cell line (U251-MG) co-tranfected with zebrafish estrogen receptors (zfERs) and the luciferase gene under the control of the zebrafish cyp19a1b gene promoter and (ii) an in vivo bioassay using a transgenic zebrafish expressing GFP under the control of the zebrafish cyp19a1b gene promoter (cyp19a1b-GFP). Concentrationresponse relationships for single chemicals were modeled and used to design the mixture experiments following a ray design. The results from mixture experiments were analyzed to predict joint effects according to concentration addition and statistical approaches were used to characterize the potential interactions between the components of the mixtures (synergism/antagonism). We confirmed that some progestins could elicit estrogenic effects in fish brain. In mixtures, EE2 and LNG exerted additive estrogenic effects both in vitro and in vivo, suggesting that some environmental progestin could exert effects that will add to those of environmental (xeno-)estrogens. Moreover, our zebrafish specific assays are valuable tools that could be used in risk assessment for both single chemicals and their mixtures.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Additive effects of levonorgestrel and ethinylestradiol on brain aromatase ( cyp19a1b ) in zebrafish specific in vitro and in vivo bioassays

Hinfray¹,

Tebby

Garoche³

et al. 2016

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

show abstract

“…Similar to estrogens and androgens, progestins can enter the aquatic environment through wastewater treatment plant effluents, and pastoral agricultural runoff (Chang et al, 2009;Mansell et al, 2011). Although environmental concentrations of progestins are generally only measured at up to tens of ng/L in surface water and hundreds of ng/L in sewage treatment plant effluents (Liu et al, 2011a), the progestins generally display high potency and specificity for biological targets (Fick et al, 2010), many of which are highly conserved between species (Gunnarsson et al, 2008). Recently, there has been a growing concern of the potential adverse impacts that Zeilinger et al, 2009) and amphibians (Hoffmann and Kloas, 2012;Kvarnryd et al, 2011;Lorenz et al, 2011;Säfholm et al, 2011) at low ng/L concentrations.…”

Section: Introductionmentioning

confidence: 99%

The progestin levonorgestrel affects sex differentiation in zebrafish at environmentally relevant concentrations

et al. 2015

View full text Add to dashboard Cite

“…Surface modification of NF membranes is well reviewed and documented by Liu et al (2011) [18]. Among others, fullerene (C60) is the potential candidate expected to show an improved performance when used to modify membrane properties [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

14N NMR Spectroscopy Study of Binding Interaction between Sodium Azide and Hydrated Fullerene

Chachibaia

Pastor

2017

View full text Add to dashboard Cite

Abstract:Our study is the first attempt to study the interaction between NaN3 and hydrated fullerenes C60 by means of a non-chemical reaction-based approach. The aim is to study deviations of signals obtained by 14 N NMR spectroscopy to detect the binding interaction between sodium azide and hydrated fullerene. We considered 14 N NMR spectroscopy as one of the most suitable methods for the characterization of azides to show resonance signals corresponding to the three non-equivalent nitrogen atoms. The results demonstrate that there are changes in the chemical shift positions and line-broadening, which are related to the different molar ratios of NaN 3 :C60 in the samples.

show abstract

Occurrence, fate and removal of synthetic oral contraceptives (SOCs) in the natural environment: A review

Cited by 93 publications

References 145 publications

Additive effects of levonorgestrel and ethinylestradiol on brain aromatase ( cyp19a1b ) in zebrafish specific in vitro and in vivo bioassays

Additive effects of levonorgestrel and ethinylestradiol on brain aromatase ( cyp19a1b ) in zebrafish specific in vitro and in vivo bioassays

The progestin levonorgestrel affects sex differentiation in zebrafish at environmentally relevant concentrations

14N NMR Spectroscopy Study of Binding Interaction between Sodium Azide and Hydrated Fullerene

Contact Info

Product

Resources

About