Occurrence, fate, persistence and remediation of caffeine: a review

Korekar, Girish; Kumar, Anupama; Ugale, Chetna

doi:10.1007/s11356-019-06998-8

Cited by 95 publications

(54 citation statements)

References 173 publications

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“…Caffeine was also detected as being mostly attributed to coffee, tea, refreshments or products containing cocoa or chocolate, but also as a component of cold medicines, painkillers, and stimulants. The highest concentrations of caffeine were found in SP 1, SP 2 and FR 2 ( Figure 2 ) and surprisingly were within those reported in environmental waters worldwide [ 15 ], indicating that senior residences do not represent an extra source of caffeine compared to the general population. Caffeine is a marker of urban contamination but also has environmental impacts [ 16 ], indicating that its monitoring is well-justified.…”

Section: Resultssupporting

confidence: 75%

Pharmaceutical Residues in Senior Residences Wastewaters: High Loads, Emerging Risks

2021

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Senior residences are health-care facilities that are socially-accepted for the assistance of elderly people. Since the elderly account for the foremost pharmaceutical-consuming age-group, senior residences become a hot-spot for pharmaceuticals discharge to the sewage grid. The objectives of the present study were to identify the bioactive pharmaceuticals in sewage waters from senior residences and to propose an on-site monitoring strategy for their control. In this study, we have studied the presence of 43 pharmaceuticals highly consumed by the elderly population in six senior residences located in Spain, France and Portugal. Wastewater was sampled directly from the water-chest in each residence during different times of the day throughout one week. Main compounds detected at the high µg L−1 level were analgesic and antipyretic drugs such as acetylsalicylic acid, paracetamol, ibuprofen; antibiotics such as amoxicillin and sulfamethoxazole; compounds for the treatment of neuropathies as gabapentin, trazodone and valsartan; pharmaceuticals for the treatment of diabetes (vildagliptin) and anticancer drugs. The daily loads discharged were estimated and their fate was evaluated. The final objective of this study is to highlight the need to implement at-source waste water treatment procedures in senior residences, which have been identified as a point source pollution of pharmaceuticals.

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Section: Resultssupporting

confidence: 75%

Pharmaceutical Residues in Senior Residences Wastewaters: High Loads, Emerging Risks

2021

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“…The ubiquous presence of caffeine can be a strong indicator of water contamination by inadequately treated sewage (Li et al, 2020). High levels of caffeine associated with the presence of sanitary e uent have been found in inland and coastal waters in Brazil and in other parts of the world, suggesting that it can be used as a tracer of anthropogenic activity (Li et S3) probably because of the estuarine dispersion to the coastal area, in the absence of additional information to safely assess the real in uence of this compound in the aquatic environment, precaution is recommended regarding its effects of the aquatic biota (Korekar et al, 2020) thereafter a quantitative structure-activity relationship modelation, predicted the effect of both parental compounds and metabolites, based on their degradability and bioaccumulative proprieties, revealing that they could be toxic to the environment and human health (Wielens Becker et al, 2020). In almost all sampling points, the compounds detected more frequently and in greater quantity were caffeine, diclofenac and losartan, with the maximum values detected in the sampling points located on the north coast (P1: losartan and diclofenac) and centre-north (P3: caffeine and losartan).…”

Section: Spatial Distribution Of Ppcps On the Coastal Waters Of Santa Catarinamentioning

confidence: 99%

First Report On The Occurrence of Pharmaceuticals And Cocaine In The Coastal Waters of Santa Catarina, Brazil, And Its Related Ecological Risk Assessment

Pisetta

Roveri

Guimarães

et al. 2021

Preprint

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The worldwide occurrence of pharmaceuticals and personal care products (PPCPs) in aquatic ecosystems is reason for concern, since these emerging micro pollutants, includes a large and diverse group of organic compounds, with continuous input, high environmental persistence and potential threat to biota and human health. The aim of this study was to evaluate, for the first time, the occurrence of twenty-seven PPCPs of various therapeutic classes (including cocaine and its primary metabolite, benzoylecgonine), in the coastal waters of Santa Catarina, southern Brazil. Water samples were taken in November 2020, during the low tide periods, at eight sampling points located along the coast of Santa Catarina, covering its entire geographical extension. Sampling was carried out in triplicate and at different depths of the water column. Nine compounds were detected through liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS): caffeine (12.58-119.80 ng/L), diclofenac (1.398-7.920 ng/L), losartan (0.432-3.200 ng/L), cocaine (0.0248-0.1686 ng/L) and benzoylecgonine (0.0146-1.094 ng/L) were quantified in 100% of the samples; carbamazepine (0.0242-0.2720 ng/L) was quantified in 75% of the samples; acetaminophen (0.212-10.040 ng/L) was quantified in 60% of the samples; and both atenolol (1.13-2.50 ng/L) and orphenadrine (0.073-0.0886 ng/L) were quantified in 25% of the samples. The other PPCPs were below the limit of detection (LOD). The highest occurrence of these compounds was detected in the northern and central coastal region of Santa Catarina, namely in Penha and Palhoça cities. The sources of these compounds may be associated with areas with high population density, awaited by tourism, with consequent production of sanitary sewage and solid waste. The ecological risk assessment of these substances in the aquatic ecosystems showed that 67% and 77% of the compounds respectively presented no ecological risk, acute and chronic, but 44% presented low to moderate risks for acute and chronic effects in the three trophic levels evaluated. The occurrence of these chemical compounds can imply deleterious effects on the environmental health of Santa Catarina coastal zone, and therefore deserve more acute and directed attention.

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“…In the latter study, 99% of study participants have detectable caffeine with a mean caffeine intake of 3.02 mg/kg/day. Although CAF consumption through diet has generally been considered safe to human health, recent studies with animal models and from human epidemiology suggest possible adverse influences on genetically susceptible populations (Cornelis et al 2006;Ding et al 2014;Findley et al 2019;Korekar et al 2019;Palatini et al 2009;Yang et al 2010;Zhou and Hypponen 2019).…”

Section: Downloaded Frommentioning

confidence: 99%

Dietary Caffeine Synergizes Adverse Peripheral and Central Responses to Anesthesia in Malignant Hyperthermia Susceptible Mice

et al. 2020

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Ryanodine receptor (RYR) mutations confer stress-triggered malignant hyperthermia susceptibility (MHS). Dietary caffeine (CAF) is the most commonly consumed psychoactive compound by humans. CAF-triggered Ca 2+ release and its influences on skeletal muscle contractility are widely used as experimental tools to study RYR function/dysfunction and diagnose MHS. We hypothesize that dietary CAF achieving This article has not been copyedited and formatted. The final version may differ from this version.

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Occurrence, fate, persistence and remediation of caffeine: a review

Cited by 95 publications

References 173 publications

Pharmaceutical Residues in Senior Residences Wastewaters: High Loads, Emerging Risks

Pharmaceutical Residues in Senior Residences Wastewaters: High Loads, Emerging Risks

First Report On The Occurrence of Pharmaceuticals And Cocaine In The Coastal Waters of Santa Catarina, Brazil, And Its Related Ecological Risk Assessment

Dietary Caffeine Synergizes Adverse Peripheral and Central Responses to Anesthesia in Malignant Hyperthermia Susceptible Mice

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