Occurrence of 17α-ethynylestradiol (EE2) in the environment and effect on exposed biota: a review

Aris, Ahmad Zaharin; Shamsuddin, Aida Soraya; Praveena, Sarva Man­gala

doi:10.1016/j.envint.2014.04.011

Cited by 457 publications

(253 citation statements)

References 156 publications

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“…Compared to the international dataset; E2 and EE2 contamination in rivers of the Carpathian basin is generally moderate. In our opinion EE2 contamination could significantly affect the endocrine systems of aquatic species over the concentration of 1ng/L (Aris et al 2014, Robinson &Hellou 2009. Considering the in vivo activity of E2; environmental risk limit should be defined approximately over 10 ng/L.…”

Section: Discussionmentioning

confidence: 90%

“…According to data published between 2003 and 2013 scientists found more than 1 ng/L E2 at least at one of their sampling sites in 13 out of 18 freshwater investigations worldwide. EE2 could be detected over 1nG/L with a 50% chance (Aris et al 2014). No detectable amount of E2 and EE2 were found in surface waters at the Mediterranean Spanish coast (with LOD 0.06 and 0.02 ng/L, respectively) (Ripolles et al 2014).…”

Section: Discussionmentioning

confidence: 93%

“…Domestic effluents and livestock waste excrete a considerable amount of hormones in addition to agriculture runoffs and industrial sources. The excreted urine contains a large part of the hormones in the form of sulfate and glucuronide conjugates, but the bacterium Escherichia coli in wastewater is able to deconjugate these metabolites due to its β-glucuronidase and sulfatase activity (Aris et al 2014, Costa et al 2010. E2, EE2 and their water soluble sulfate and glucuronide metabolites enter natural streams, rivers, lakes mainly through cleaned wastewater.…”

Section: Introductionmentioning

confidence: 99%

“…(Bhandari et al 2015, Huang et al 2015, Yan et al 2012. Considering their diverse role in the regulation of endogenous processes, quantitation of these two chemicals is very useful not only in the clinical assessment but also in environmental investigations (Aris et al 2014). In the European Union pharmaceuticals authorization procedures include Comission directives, which contain a requirement to develop a strategic approach to the pollution of water by pharmaceutical substances.…”

Section: Introductionmentioning

confidence: 99%

“…1.1 Rationale and aims Our aim was to develop a specific and selective LC-MS method for the determination of the most potent natural estrogen, E2, and the probably most used synthetic estrogen, EE2. We were also determined to measure these endocrine disrupting compounds (EDCs) in Lake Balaton and in Central European rivers, because there is very limited data published about the occurrence of EE2 in the Carpathian basin (Aris et al 2014). As EDCs in waters can not only occur in dissolved form (Andrasi et al 2013, Faludi et al 2015, but associate with suspended particles also, we decided to measure the dissolved and suspended phases separately as well.…”

Section: Introductionmentioning

confidence: 99%

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β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

Avar

Zrínyi²,

Maász

et al. 2016

Environ Sci Pollut Res

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17β-estradiol (E2) and 17α-ethinyl estradiol (EE2), which are environmental estrogens have been determined with LC-MS in freshwater. Their sensitive analysis needs derivatisation and therefore is very hard to achieve in multiresidue screening. We analysed samples from all the large and some small rivers (River Danube, Drava, Mur, Sava, Tisza and Zala) of the Carpathian Basin and from Lake Balaton. Freshwater was extracted on solid phase and derivatised using dansyl-chloride. Separation was performed on a Kinetex XB-C18 column. Detection was achieved with a benchtop orbitrap mass spectrometer using targeted MS analysis for quantification. Limits of quantification were 0.05 ng/L (MS1) and 0.1 ng/L (MS/MS) for E2, and 0.001 ng/L (MS1) and 0.2 ng/L (MS/MS) for EE2. River samples contained n.d.-5.2 ng/L E2 and n.d.-0.68 ng/L EE2. Average levels of E2 and EE2 were 0.61 and 0.084 ng/L respectively in rivers, water courses and Lake Balaton together, but not counting city canal water. EE2 was less abundant, but it was still present in almost all of the samples. In beach water samples from Lake Balaton we measured 0.076-0.233 E2 and n.d.-0.133 EE2. A relative high amount of EE2 was found in river Zala (0.68 ng/L) and in Hévíz-Páhoki canal (0.52 ng/L), which are both in the catchment area of Lake Balaton (Hungary). HighlightsMethod is proposed for simultaneous determination of 17β-estradiol and 17α-ethinyl estradiol. Derivatization is necessary to reach low LOQ. Low ng/L presence of estrogens in selected European Rivers has been detected.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

Avar

Zrínyi²,

Maász

et al. 2016

Environ Sci Pollut Res

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17α‐Ethynylestradiol‐induced changes in Brassica rapa during the seedling growth stage

Wijewardana

Gonzales

Vogel

et al. 2022

Agrosystems Geosci & Env

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Estrogens and estrogen-like compounds are considered contaminants of emerging concern due to their endocrine disrupting capability and potential to build up in soil and aquatic environments, although little is known about the effects of estrogenic compounds on plant life. This research aims to understand the effect of the synthetic hormone 17-α ethynylestradiol (EE2) on Brassica rapa L. (field mustard) root and shoot vigor at the seedling stage. Endpoints considered included: plant height; root, shoot, and total dry biomass; number of leaves and inflorescences; leaf carbon and nitrogen; root growth traits (length, surface area, diameter, and volume); and root developmental parameters (tips, forks, and crossings). Tukey's method for multiple comparisons was used to determine the significance of pairwise differences between treatment means for each endpoint. 17-α Ethynylestradiol acted generally as a biostimulant at the concentrations considered (0, 0.5, 1, 5, 10, and 15 μg L −1 ), with the most pronounced differences occurring in seedlings treated with 1 μg L −1 EE2.Although number of leaves and biomass appeared to be inhibited at EE2 concentrations of ≥5 μg L −1 and ≥10 μg L −1 , respectively, all other traits in estrogen-treated plants were similar or improved compared with the control plants. Study results suggest that at certain concentrations, EE2 contributes to more structured root systems, triggering vigorous plant development that may potentially enhance a successful seedling establishment.

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Size‐Dependent Inhibition of Sperm Motility by Copper Particles as a Path toward Male Contraception

Chattopadhyay

Magdanz

Hernández-Meliá

et al. 2022

Advanced NanoBiomed Research

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Occurrence of 17α-ethynylestradiol (EE2) in the environment and effect on exposed biota: a review

Cited by 457 publications

References 156 publications

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

17α‐Ethynylestradiol‐induced changes in Brassica rapa during the seedling growth stage

Size‐Dependent Inhibition of Sperm Motility by Copper Particles as a Path toward Male Contraception

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