Occurrence of depression and its correlates in early onset dementia patients

Rosness, Tor Atle; Barca, Maria Lage; Engedal, Knut

doi:10.1002/gps.2411

Cited by 63 publications

(63 citation statements)

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“…Depression is a common and disabling disorder in later life [13,27], and while subjects with depression have been reported to have significantly lower scores for activity of daily living (ADL) and quality of life (QOL) than those without depression [28], depression in the elderly has also been reported to be associated with poor cognitive function [29], dementia [30], developing AD [31], premotor symptoms in PD [32], and cerebrovascular disease [33]. Viewing these findings together with the organic pathological changes of the brain, leads us to believe that such brain changes may influence both the mood as well as motor function of the elderly who only have mild symptoms of neurodegenerative disease.…”

Section: Discussionmentioning

confidence: 99%

Mild parkinsonian signs in a community-dwelling elderly population sample in Japan

Uemura

Wada‐Isoe

Nakashita

et al. 2011

Journal of the Neurological Sciences

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Mild parkinsonian signs (MPS) may represent the mild end of a disease spectrum that spans from normal aging to neurodegenerative diseases. We conducted a population-based study in a rural island town in western Japan, Ama-cho. Participants included 1129 subjects, aged 60 years and older, residing in the town. Participants were classified according to a modified Unified Parkinson's Disease Rating Scale (mUPDRS) score. MPS was determined to be present if any of the following conditions were met: (1) two or more mUPDRS ratings=1 [MPS-mild]; (2) one mUPDRS rating≥2; or (3) mUPDRS rest tremor rating≥1; [(2) and (3): MPS-severe]. Subjects wore a uniaxial accelerometer (Actiwatch), resulting in the measurement of actigraphic activity counts (AC). Of the 804 participants with complete data, 178 subjects (22.1%) were classified as demonstrating MPS. AC was significantly lower in the MPS-severe group compared with both the CTL and the MPS-mild groups. Diagnostic sensitivity for MPS-severe became 100% when we adopted a cutoff point of low physical activity, as measured by actigraphy, combined with the presence of subjective depression. We established the prevalence of MPS in a community-dwelling elderly population sample in Japan. Actigraphy may be a useful objective tool for screening MPS-severe.

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Section: Discussionmentioning

confidence: 99%

Mild parkinsonian signs in a community-dwelling elderly population sample in Japan

Uemura

Wada‐Isoe

Nakashita

et al. 2011

Journal of the Neurological Sciences

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“…It is also within the range of 25-66% reported in four separate studies of community-based populations (vs. institutionalized or hospitalized) with diagnosed dementia that have employed different instruments to assess depressive symptomatology. Specifically, a 25% prevalence rate of depressive symptoms as assessed with the Cornell Scale for Depression in Dementia (CSDD) was reported in a study of memory clinic patients diagnosed with dementia due to AD [33]; among individuals diagnosed with probable AD dementia, a prevalence rate of 40% was reported as assessed with the Columbia University Scale for Psychopathology in Alzheimer's Disease (CUSPAD) [34]; a 49% prevalence rate of depressive symptoms was assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS) among individuals referred to outpatient clinics specializing in geriatrics and older psychiatry diagnosed with a dementia type [35], and a prevalence rate of 66%, also assessed with the MADRS, was reported in a study of memory clinic patients diagnosed with early-onset dementia [36]. …”

Section: Discussionmentioning

confidence: 99%

Prevalence and Covariates of Elevated Depressive Symptoms in Rural Memory Clinic Patients with Mild Cognitive Impairment or Dementia

Kosteniuk

Morgan

O’Connell³

et al. 2014

Dement Geriatr Cogn Disord Extra

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Background/Aims: To estimate the prevalence, severity, and covariates of depressive symptoms in rural memory clinic patients diagnosed with either mild cognitive impairment (MCI) or dementia. Methods: In a cross-sectional study of 216 rural individuals who attended an interdisciplinary memory clinic between March 2004 and July 2012, 51 patients were diagnosed with MCI and 165 with either dementia due to Alzheimer's disease (AD) or non-AD dementia. The Center for Epidemiologic Studies of Depression Scale (CES-D) was used to estimate the severity and prevalence of clinically elevated depressive symptomatology. Results: The prevalence of elevated depressive symptoms was 51.0% in the MCI patients and 30.9% in the dementia patients. Depressive symptoms were more severe in the MCI patients than in the dementia patients. Elevated depressive symptoms were statistically associated with younger age for the MCI group, with lower self-rated memory for the dementia group, and with increased alcohol use and lower quality of life ratings for all patients. In the logistic regression models, elevated depressive symptoms remained negatively associated with self-rated memory and quality of life for the patients with dementia, but significant bivariate associations did not persist in the MCI group. Conclusions: The high prevalence and severity of depressive symptoms among rural memory clinic patients diagnosed with either MCI or dementia warrant continued investigation.

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“…It has been suggested that younger dementia patients may display more neuropsychiatric problems, specifically affective symptoms, because a dementia diagnosis at a young age can result in more unexpected loss of independence and isolation [9,10]. However, the few studies comparing YO-AD with late-onset AD (LO-AD) have shown equivocal results.…”

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confidence: 91%

Prevalence of Neuropsychiatric Symptoms in Young-Onset Compared to Late-Onset Alzheimer’s Disease – Part 1: Findings of the Two-Year Longitudinal NeedYD-Study

Vliet

Vugt

Aalten

et al. 2012

Dement Geriatr Cogn Disord

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Background/Aims: Knowledge about neuropsychiatric symptoms in young-onset Alzheimer’s disease (YO-AD) is scarce, but essential to establish a prognosis and plan care for YO-AD patients. The aim of this study is to assess frequency parameters of neuropsychiatric symptoms in YO-AD over 2 years and investigate whether there are differences compared with late-onset Alzheimer’s disease (LO-AD). Methods: 98 YO-AD and 123 LO-AD patients and caregivers from two prospective cohort studies were included and assessed every 6 months for 2 years, using the Neuropsychiatric Inventory to evaluate neuropsychiatric symptoms. Results: Over the course of 2 years, the incidence, prevalence and persistence of neuropsychiatric symptoms were in general lower in YO-AD than in LO-AD, specifically for delusions, agitation, depression, anxiety, apathy, irritability and aberrant motor behavior. Frequency of individual symptoms showed large variability in both groups. Within the group of YO-AD patients, apathy was the most prevalent symptom. Conclusion: Neuropsychiatric symptoms, notably apathy, should be paid appropriate attention to in the diagnosis and treatment of YO-AD patients. Further research is needed to gain insight into the mechanisms underlying the differences in neuropsychiatric symptoms between YO-AD and LO-AD.

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Occurrence of depression and its correlates in early onset dementia patients

Abstract: We found a high occurrence of depressive symptoms in EOD patients; 65.7% of all our patients had some degree of depression. A history of depression was the most important correlate of depression in these patients.

Cited by 63 publications

References 50 publications

Mild parkinsonian signs in a community-dwelling elderly population sample in Japan

Mild parkinsonian signs in a community-dwelling elderly population sample in Japan

Prevalence and Covariates of Elevated Depressive Symptoms in Rural Memory Clinic Patients with Mild Cognitive Impairment or Dementia

Prevalence of Neuropsychiatric Symptoms in Young-Onset Compared to Late-Onset Alzheimer’s Disease – Part 1: Findings of the Two-Year Longitudinal NeedYD-Study

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