Occurrence of other tumors in patients with GIST

Gonçalves, Rinaldo; Linhares, Eduardo; Albagli, Rafael; Valadão, Marcus; Vilhena, Bruno; Romano, Sérgio; Ferreira, Carlos Gil

doi:10.1016/j.suronc.2010.06.004

Cited by 59 publications

(53 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nonepithelial gastric neoplasms which are coincidental with other neoplasms concern predominantlyGISTexistingwithsomeformofgastric cancersorlymphomas [12][13][14][15][16][17][18][19].Indailypracticethis isobservedfairlyoftenandusuallyGISTsarefindings incidentaltothemainmalignancyandareoftenina groupwitha"lowrecurrentpercentage"often.Furthermore, the meaning existing GISTs is sometimes discussedinlightofsecondarytumorsasderivateto chemical GIST therapy. Only a few works have describedapotentialconnectionofGISTwithcancerin extra-gastriclocalization.Gonçalveset alinastudy onagroupof101gastricGISTtumorsobserved13% occurrenceofanothermalignancy [20].Coincidence ofsimultaneousGISTandanotherGImalignancysimiliartotheabove-mentionedonereportedbyWronskiet alandRukaet al [21,22]. Relatively few papers have described extra-gastric tissue within duplication.…”

Section: Discussionmentioning

confidence: 94%

Gastric gastrointestinal stromal tumor with incomplete duplication cyst – a case with possibility of neoplasia in fetal-period malformed tissues

Lewitowicz¹,

Matykiewicz²,

Kozieł³

et al. 2015

pjp

View full text Add to dashboard Cite

ThecoincidenceofGISTandothergastricmalignanciesaredocumentedwellbut arisingGISTfromcongenitalanomaliesisstillrarityinliterature.Todate,only a few papers have been concerned on the possibility of arising neoplasms from duplicationcystofgastrointestinaltract.There,aredominatingusualcancers,neuroendocrinecancersorlymphomasbutGISThasbeennotedonlyonce.Here,we report a case of 73 years old female-patient with typical gastric stromal tumor comprisedcentrallylockedanincompleteduplicationcyst.

show abstract

Section: Discussionmentioning

confidence: 94%

Gastric gastrointestinal stromal tumor with incomplete duplication cyst – a case with possibility of neoplasia in fetal-period malformed tissues

Lewitowicz¹,

Matykiewicz²,

Kozieł³

et al. 2015

pjp

View full text Add to dashboard Cite

show abstract

“…It may be [31] reported that GISTs coexisted with other neoplasms in 27 % of the study population. Gonçalves et al [32] reported a 13.8 % incidence of non-GIST tumors in a series of 101 GIST cases. In our study, 2 (11.1 %) of 18 patients with GISTs synchronously had other primary tumors.…”

Section: Discussionmentioning

confidence: 98%

Clinicopathologic differences of mesenchymal submucosal tumors between the esophagogastric junction and the upper stomach

et al. 2013

View full text Add to dashboard Cite

Objective We compared the clinicopathologic features between mesenchymal tumors located in the esophagogastric junction (EGJ) and upper stomach, that had been removed surgically. Methods Thirty-five patients with a submucosal tumor (SMT) of the stomach, including the EGJ, were surgically treated over the last decade. Of these, 23 patients with SMTs located in the upper third of the stomach (n = 15; UG-group) and EGJ (n = 8; EGJ-group) were studied. Results The mean age was younger in the EGJ-group than in the UG-group, and the EGJ-group frequently showed symptoms. Histopathologically, 4 gastrointestinal stromal tumors (GISTs) and 4 leiomyomas were observed in the EGJ-group, while 14 GISTs and one schwannoma were observed in the UG-group (p = 0.0096). Two tumors macroscopically showed a horseshoe or spiral type in the EGJ-group, while all tumors showed a ball/ball-like appearance in the UG-group. Regarding surgical procedures, 7 patients underwent laparotomy in the EGJ-group, while 9 patients underwent laparoscopic surgery in the UG-group. The mean operating time was longer and operative bleeding was greater in the EGJ-group than in the UG-group, respectively (p = 0.0015 and p = 0.0095). Postoperative complications were frequently observed in the EGJ-group. The EGJ-group showed no patients with recurrence and/or metastasis after surgery, while three cases with GISTs had them in the UG-group. In GISTs, the mean mitotic index of the UG-group was relatively more than that of the EGJ-group and a case was classified into the high-risk group, although there was no significance in the risk classification between the two groups. Conclusion SMTs included GISTs and leiomyomas in the EGJ, while the majority demonstrated GISTs in the upper stomach. SMTs of the EGJ were removed by a tailored approach to prevent recurrence as well as postoperative complications. The biological behavior of GISTs may be different between the EJG and stomach.

show abstract

“…GISTs can coexist with different types of cancer, either synchronically or metachronically. In 14-20 % of the patients, this association appears mainly with solid tumors (5). Gastric GISTs are the most common ones to be involved with other tumors, and the most frequents are: gastrointestinal adenocarcinomas (stomach and colon), renal cell carcinoma, prostate, lung, female genital tract, and carcinoid tumors (6).…”

Section: Discussionmentioning

confidence: 99%