Occurrence of Pasteurella multocida among pigs with respiratory disease in China between 2011 and 2015

Abstract

BackgroundPrior to the 1990s, P. multocida capsular serogroup A was the most prevalent in China, followed by serogroups B and D. Thirty years later, serogroup D became the most prevalent, followed by serogroups A and B. However, the P. multocida capsular serogroups currently circulating in China remain unclear. Therefore, the aim of the present study was to provide an update on P. multocida serogroups isolated from diagnostic samples collected from clinically diseased pigs in Central and Eastern China from 2011 to 2015.ResultsBetween February 2011 and October 2015, 296 isolates of Pasteurella multocida were collected from 3212 pigs with clinical respiratory disease in 12 provinces of China (isolation rate of 9.2%). Of the 296 collected isolates, 146 (49.3%) were P. multocida capsular type A, 141 (47.6%) were capsular type D, and one was capsular type B. Streptococcus suis (94/193; 48.7%), Haemophilus parasuis (76/193; 39.3%), Escherichia coli (53/193; 27.5%), and Bordetella bronchiseptica (26/193; 13.5%) were frequently isolated together with P. multocida. A total of 14 toxigenic P. multocida strains co-isolated with other pathogens from 32 cases of atrophic rhinitis were classified into serogroup D. The virulence of P. multocida capsular type A isolates was higher than that of capsular type D isolates based on LD50 studies in mice.ConclusionsOver the past 5 years, P. multocida capsular type A was the most frequently isolated from diagnostic submissions in Central and Eastern China, followed by serogroups D and B.

Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species

“…The predominate capsule: LPS genotypes defined among the porcine isolates were types D: L6 (42.86%), A: L3 (25.00%), and A: L6 (23.21%). Those are because P. multocida strains with porcine pasteurellosis are frequently designated capsular types A and D (Tang et al, 2009 ; Liu et al, 2017 ; Peng et al, 2018 ), and LPS serovars 3, 4, and 12 (Pijoan et al, 1983 ; Lainson et al, 2002 ; Jamaludin et al, 2005 ). In particular, these results are in agreement with the latest molecular epidemical data in China (Peng et al, 2018 ).…”

Comparison of Oropharyngeal Microbiota in Healthy Piglets and Piglets With Respiratory Disease

“…Another genus, Pasteurella , was relatively abundant in the diseased groups from the two farms, even though no statistical significance was observed ( p > 0.05). P. multocida is an opportunistic pathogen and a common inhabitant of the upper respiratory tract of many animals, and a causative agent of numerous important diseases, including respiratory diseases (Hansen et al, 2010; Liu et al, 2017). In addition, a high prevalence of P. multocid a was demonstrated from cases of porcine bronchopneumonia, which was considered a secondary pathogen, dependent on co-infections or immunosuppression of the host (Pors et al, 2011).…”

. Serotype detection, molecular characterization and genetic relationship study on Pasteurella multocide local isolate

“…P. multocide along with the Bordetella bronchiseptica causes acute atrophic rhinitis to pig related to high strain toxigenicity, because the P. multocide play a dominant role leading to the development of anthropic rhinitis lesi (Magyar et al 2013;Kubatzky 2012;Shayegh et al 2009) as well as it is related to pneumonia and septicemia diseases (De Oliveira et al 2015). Liu et al (2017) reported that prevalence of P. multocide Serotype A is the most common in China before 1990 followed by serotype B and D.…”