Occurrence of pharmaceuticals and endocrine disrupting compounds in macroalgaes, bivalves, and fish from coastal areas in Europe

Álvarez-Muñoz, Diana; Rodríguez-Mozaz, Sara; Maulvault, Ana Luísa; Tediosi, Alice; Fernández-Tejedor, Margarita; Heuvel, Frank Van den; Kotterman, M.J.J.; Marques, António; Barceló, Damià

doi:10.1016/j.envres.2015.09.018

Cited by 224 publications

(102 citation statements)

References 41 publications

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“…Authors reported the presence of four PhACs: the antibiotic azithromycin, β‐blockers metroprolol, to a lesser extent propanolol, and the psychiatric drug diazepam. Other PhACs and endocrine‐disrupting compounds (EDCs) were measured but reported to be below the detection limit (Álvarez‐Muñoz et al., ). Overall, the detected concentrations of PhACs and EDCs measured in this study were higher in bivalves and fish than that of seaweed.…”

Section: Resultsmentioning

confidence: 99%

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Food safety hazards in the European seaweed chain

Banach

Hil

Fels‐Klerx

2020

Comp Rev Food Sci Food Safe

136

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Seaweed is a source of protein that can help overcome the anticipated challenges of a growing world population and the current challenges for finding alternatives for animal proteins in the Western diet. Thus far, data on the safety of seaweed for feed and food purposes in the Western world are scattered. This study aimed to review the available knowledge on the presence of food safety hazards in seaweed, including factors influencing their presence, and to prioritize the hazards that may pose a risk to human health. Given current knowledge from the literature, data from the Rapid Alert System for Food and Feed, and results from a stakeholder survey, 22 food safety hazards were ranked into major (4), moderate (5), and minor (13) hazards. Arsenic, cadmium, iodine, and Salmonella were identified as major hazards. Hazards, where data gaps exist, should be carefully assessed. These include pesticide residues, dioxins and polychlorinated biphenyls, brominated flame retardants, polycyclic aromatic hydrocarbons, pharmaceuticals, marine biotoxins, allergens, micro‐ and nanoplastics, other pathogenic bacteria, norovirus, and hepatitis E virus. It is recommended to collect more data on these hazards in future studies. Many factors can affect the presence of hazards including seaweed type, physiology, season, harvest and cultivation environment, geography including the location of cultivation, alongside further processing. Moreover, when seaweed is cultivated near industrialized or anthropogenic activities, these activities may negatively influence water quality, which can increase the likelihood of hazards in seaweed. Results of the ranking prioritized hazards can be used to prioritize monitoring programs and adjusted given future additional knowledge covering the data gaps.

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Section: Resultsmentioning

confidence: 99%

“…Pharmaceuticals can include pharmaceutically active compounds (PhACs) in therapeutic groups such as antibiotics, -blockers, psychiatric drugs, etc. (Álvarez-Muñoz et al, 2015;Vandermeersch et al, 2015). The exposure of such compounds to aquatic organisms results in their potential bioaccumulation.…”

Section: 181mentioning

confidence: 99%

Food safety hazards in the European seaweed chain

Banach

Hil

Fels‐Klerx

2020

Comp Rev Food Sci Food Safe

136

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“…Furthermore, risks of selection for Vibrio could also be enhanced in bivalve shellfish, which are a common exposure route for Vibrio infections (Slayton et al, 2014;Froelich et al, 2016). Bioaccumulation of triclosan in clams and mussels has been noted at concentrations ranging from 1.7 to 2578 µg kg -1 (Gatidou et al, 2010;Kookana et al, 2013;Álvarez-Muñoz et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Effects of triclosan on bacterial community composition and Vibrio populations in natural seawater microcosms

Lydon

Glinski

Westrich

et al. 2017

Elementa: Science of the Anthropocene

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Pharmaceuticals and personal care products, including antimicrobials, can be found at trace levels in treated wastewater effluent. Impacts of chemical contaminants on coastal aquatic microbial community structure and pathogen abundance are unknown despite the potential for selection through antimicrobial resistance. In particular, Vibrio, a marine bacterial genus that includes several human pathogens, displays resistance to the ubiquitous antimicrobial compound triclosan. Here we demonstrated through use of natural seawater microcosms that triclosan (at a concentration of ~5 ppm) can induce a significant Vibrio growth response (68–1,700 fold increases) in comparison with no treatment controls for three distinct coastal ecosystems: Looe Key Reef (Florida Keys National Marine Sanctuary), Doctors Arm Canal (Big Pine Key, FL), and Clam Bank Landing (North Inlet Estuary, Georgetown, SC). Additionally, microbial community analysis by 16 S rRNA gene sequencing for Looe Key Reef showed distinct changes in microbial community structure with exposure to 5 ppm triclosan, with increases observed in the relative abundance of Vibrionaceae (17-fold), Pseudoalteromonadaceae (65-fold), Alteromonadaceae (108-fold), Colwelliaceae (430-fold), and Oceanospirillaceae (1,494-fold). While the triclosan doses tested were above concentrations typically observed in coastal surface waters, results identify bacterial families that are potentially resistant to triclosan and/or adapted to use triclosan as a carbon source. The results further suggest the potential for selection of Vibrio in coastal environments, especially sediments, where triclosan may accumulate at high levels.

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“…Besides, marine species in coastal areas may also be exposed to pharmaceuticals through effluent discharges, waste disposal, and the use of drugs in aquaculture. The impact of this exposure, however, has received very little attention, and studies reporting the detection of human drug residues in wild marine fish species are very scarce [4][5][6]. This is surprising because the occurrence of pharmaceuticals in estuaries and potential contaminated areas has raised concerns about potential adverse effects on the species living on them.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, diazepam was measured in marine flatfish collected near ocean discharges of municipal wastewater effluent. More recently, Álvarez-Muñoz et al reported the presence of several pharmaceuticals, including metoprolol, azithromycin, and venlafaxine, in the different trophic levels of the food chain from coastal areas [4]. Other authors reported the presence of carbamazepine (CBZ) [8,9] in different marine species being Published in the topical collection Advances in LC-MS/MS Analysis with guest editors Damià Barceló and Mira Petrovic.…”

Section: Introductionmentioning

confidence: 99%

Metabolite profiling of carbamazepine and ibuprofen in Solea senegalensis bile using high-resolution mass spectrometry

et al. 2017

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The widespread occurrence of pharmaceuticals in the aquatic environment has raised concerns about potential adverse effects on exposed wildlife. Very little is currently known on exposure levels and clearance mechanisms of drugs in marine fish. Within this context, our research was focused on the identification of main metabolic reactions, generated metabolites, and caused effects after exposure of fish to carbamazepine (CBZ) and ibuprofen (IBU). To this end, juveniles of Solea senegalensis acclimated to two temperature regimes of 15 and 20°C for 60 days received a single intraperitoneal dose of these drugs. A control group was administered the vehicle (sunflower oil). Bile samples were analyzed by ultra-high-performance liquid chromatography-high-resolution mass spectrometry on a Q Exactive (Orbitrap) system, allowing to propose plausible identities for 11 metabolites of CBZ and 13 metabolites of IBU in fish bile. In case of CBZ metabolites originated from aromatic and benzylic hydroxylation, epoxidation, and ensuing O-glucuronidation, O-methylation of a catechol-like metabolite was also postulated. Ibuprofen, in turn, formed multiple hydroxyl metabolites, Oglucuronides, and (hydroxyl)-acyl glucuronides, in addition to several taurine conjugates. Enzymatic responses after drug exposures revealed a water temperature-dependent induction of microsomal carboxylesterases. The metabolite profiling in fish bile provides an important tool for pharmaceutical exposure assessment.

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Occurrence of pharmaceuticals and endocrine disrupting compounds in macroalgaes, bivalves, and fish from coastal areas in Europe

Cited by 224 publications

References 41 publications

Food safety hazards in the European seaweed chain

Food safety hazards in the European seaweed chain

Effects of triclosan on bacterial community composition and Vibrio populations in natural seawater microcosms

Metabolite profiling of carbamazepine and ibuprofen in Solea senegalensis bile using high-resolution mass spectrometry

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