Occurrence of pharmaceuticals in a municipal wastewater treatment plant: Mass balance and removal processes

Gao, Pin; Ding, Yanhong; Li, Hui; Xagoraraki, Irene

doi:10.1016/j.chemosphere.2012.02.017

Cited by 282 publications

(97 citation statements)

References 32 publications

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“…The concentrations of NOR (0.3e527 ng/L) were much higher than those detected in wastewater samples of Europe Union (7e80 ng/L) (Andreozzi et al, 2003), and the highest concentration of TMP in this study was 813 ng/L, which is 1.6 and 1.7 time lower than those found in Sweden (1300 ng/L) and USA (1400 ng/L) (Brown et al, 2006;Lindberg et al, 2005). More than 90% of the influent concentrations of tetracyclines were below 70 ng/L, considerably lower than those (178e309 ng/L) reported in the large-scale WWTPs of China (Gao et al, 2012b). Sulfonamides showed the lowest concentrations, with most of their maximum values being less than 65 ng/L.…”

Section: Detection Frequency and Concentration Range Of Target Antibimentioning

confidence: 45%

Occurrence and removal of antibiotics in ecological and conventional wastewater treatment processes: A field study

Dong

Yuan

Wang

et al. 2016

Journal of Environmental Management

150

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a b s t r a c tThe occurrence and removal of 19 antibiotics (including four macrolides, eight sulfonamides, three fluoroquinolones, three tetracyclines, and trimethoprim) were investigated in two ecological (constructed wetland (CW) and stabilization pond (SP)) and two conventional wastewater treatment processes (activated sludge (AS) and micro-power biofilm (MP)) in a county of eastern China. All target antibiotics were detected in the influent and effluent samples with detection frequencies of >90%. Clarithromycin, ofloxacin, roxithromycin and erythromycin-H 2 O were the dominant antibiotics with maximum concentrations reaching up to 6524, 5411, 964 and 957 ng/L, respectively; while the concentrations of tiamulin, sulfamerazine, sulfathiazole, sulfamethazine, sulfamethizole and sulfisoxazole were below 10 ng/L. Although the mean effluent concentrations of target antibiotics were obviously lower than the influent ones (except ciprofloxacin), their removals were usually incomplete. Principal component analysis showed that the AS and CW outperformed the MP and SP processes and the AS performed better than the CW process in terms of antibiotics removal. Both the AS and CW processes exhibited higher removal efficiencies in summer than in winter, indicating biological degradation could play an important role in antibiotics removal. Because of the incomplete removal, the total concentration of detected antibiotics increased in the mixing and downstream sections of a local river receiving the effluent from a typical wastewater treatment facility practicing AS process. Nowadays, ecological wastewater treatment processes are being rapidly planned and constructed in rural areas of China; however, the discharge of residual antibiotics to the aquatic environment may highlight a necessity for optimizing or upgrading their design and operation.

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Section: Detection Frequency and Concentration Range Of Target Antibimentioning

confidence: 45%

Occurrence and removal of antibiotics in ecological and conventional wastewater treatment processes: A field study

Dong

Yuan

Wang

et al. 2016

Journal of Environmental Management

150

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“…However, this could not be confirmed as the metabolites were not monitored (Plósz et al 2010). The most recent investigation has found that of the 90 % SMX removal achieved overall during conventional WW treatment, approximately 50 % can be attributed to biological treatment/AS with no significant sorption to sludge (Gao et al 2012a). Again, the variation in the observed SMX removals may be attributed to differences in: microbial community of the AS systems, treatment plant operation (SRT and HRT), sampling methods (automated vs. grab sampling; frequency), and times (seasonal variation).…”

Section: Removal In Full-scale Wwtps Based On Asmentioning

confidence: 99%

“…The synthetic compound sulfamethoxazole (SMX) is one of the most popularly prescribed and consumed sulfonamide antibiotics (Cavallucci 2007;Hruska and Franek 2012) leading to its presence in the aquatic environment via WW discharge (Avisar et al 2009;Santos et al 2010) and its frequent detection in WWs at up to microgram-per-liter levels and surface waters at nanogram-per-liter levels (Batt et al 2007;Joss et al 2005;Kolpin et al 2002;Miège et al 2009;Peng et al 2006;Yargeau et al 2007;Gao et al 2012a). At these concentrations, SMX has been found to be mutagenic but not acutely toxic to Vibrio fisheri and Daphnia magna (Isidori et al 2005) and to be phytotoxic to algae (García-Galán et al 2011) and other plant species (Hillis et al 2011).…”

Section: Smx Usage and Presence In The Environmentmentioning

confidence: 99%

Biodegradation of sulfamethoxazole: current knowledge and perspectives

Larcher

Yargeau

2012

Appl Microbiol Biotechnol

121

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Antibiotic compounds, like sulfamethoxazole (SMX), have become a concern in the aquatic environment due to the potential development of antibacterial resistances. Due to extensive consumption, excretion and disposal, SMX has been frequently detected in wastewaters and surface waters. This has led to numerous studies investigating the nature of SMX, with many researchers focusing on the biodegradation and persistence of SMX during wastewater treatment and in the environment. This review provides a summary of recent developments, outlines the discrepancies in observations and results, and demonstrates the need for further research to determine optimal biological removal strategies for SMX and other antibiotics.

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“…A limited number of previous studies have taken a 70 mass balance approach to determine removals of CECs in conventional primary and secondary 71 treatment steps through the processes of adsorption and (bio)degradation that were the major removal 72 mechanisms for the CECs investigated (Carballa et al, 2007;Gao et al, 2012;Heidler & Halden, 73 2008;Jelic et al, 2011;Petrie et al, 2014;Wick et al, 2009;Winkler et al, 2007). The majority of 74 these studies were based on analysis of CECs in grab or 24-h composite wastewater samples 75 collected simultaneously from different treatment stages, while a small number of studies accounted 76 for the hydraulic retention time in the sampling campaign but did not consider the wastewater 77 residence time distribution.…”

mentioning

confidence: 99%

Fate and mass balance of contaminants of emerging concern during wastewater treatment determined using the fractionated approach

Baalbaki

Sultana

Maere

et al. 2016

Science of The Total Environment

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Contaminants of emerging concern (CECs) are often poorly removed from wastewater using conventional treatment technologies and there is limited understanding of their fate during treatment. Inappropriate sampling strategies lead to inaccuracies in estimating removals of CECs. In this study, we used the “fractionated approach” that accounts for the residence time distribution (RTD) in treatment units to investigate the fate of 26 target CECs in a municipal wastewater treatment plant (WWTP) that includes primary, secondary and tertiary treatment steps[...] Analysis of the selected metabolites demonstrated that negative removals obtained could be explained by transformations between the parent compound and their metabolites. This study contributes to the growing literature by applying the fractionated approach to calculate removal of different types of CECs across each wastewater treatment step. An additional level of understanding of the fate of CECs was provided by mass balance calculations in primary and secondary treatments

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Occurrence of pharmaceuticals in a municipal wastewater treatment plant: Mass balance and removal processes

Cited by 282 publications

References 32 publications

Occurrence and removal of antibiotics in ecological and conventional wastewater treatment processes: A field study

Occurrence and removal of antibiotics in ecological and conventional wastewater treatment processes: A field study

Biodegradation of sulfamethoxazole: current knowledge and perspectives

Fate and mass balance of contaminants of emerging concern during wastewater treatment determined using the fractionated approach

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