Occurrence of polar organic contaminants in the dissolved water phase of the Danube River and its major tributaries using SPE-LC-MS2 analysis

Loos, Robert; Giovanni, Locoro; Contini, S.

doi:10.1016/j.watres.2009.12.035

Cited by 195 publications

(123 citation statements)

References 36 publications

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“…These limits are 0.035 ng/L for EE2 and 0.4 ng/L for E2 (European Parliament 2015). These contaminants in an average equipped laboratory using multiresidue analysis without derivatization can only be determined with poor LOQ values (Liu et al 2011b, Loos et al 2010, Ripolles et al 2014). Our methodology with dansyl derivatization is cheap, quick and simple enough to be considered for use in monitoring studies in the future.…”

Section: Discussionmentioning

confidence: 99%

“…Full MS and targeted MS/MS methods without derivatization, which are generally used in environmental monitoring applications, detect 40-100 or even more target compounds. These screening methods however often do not include or cannot detect E2 and EE2 due to poor detection limits (Chitescu et al 2015, Kuster et al 2008, Liu et al 2011b, Loos et al 2010. Evaluation of derivatives of estrogens makes positive mode electrospray ionization (ESI) mass spectrometric detection possible and improves generally the sensitivity of MS methods (Anari et al 2002, Xu &Spink 2008.…”

Section: Introductionmentioning

confidence: 99%

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β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

Avar

Zrínyi²,

Maász

et al. 2016

Environ Sci Pollut Res

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17β-estradiol (E2) and 17α-ethinyl estradiol (EE2), which are environmental estrogens have been determined with LC-MS in freshwater. Their sensitive analysis needs derivatisation and therefore is very hard to achieve in multiresidue screening. We analysed samples from all the large and some small rivers (River Danube, Drava, Mur, Sava, Tisza and Zala) of the Carpathian Basin and from Lake Balaton. Freshwater was extracted on solid phase and derivatised using dansyl-chloride. Separation was performed on a Kinetex XB-C18 column. Detection was achieved with a benchtop orbitrap mass spectrometer using targeted MS analysis for quantification. Limits of quantification were 0.05 ng/L (MS1) and 0.1 ng/L (MS/MS) for E2, and 0.001 ng/L (MS1) and 0.2 ng/L (MS/MS) for EE2. River samples contained n.d.-5.2 ng/L E2 and n.d.-0.68 ng/L EE2. Average levels of E2 and EE2 were 0.61 and 0.084 ng/L respectively in rivers, water courses and Lake Balaton together, but not counting city canal water. EE2 was less abundant, but it was still present in almost all of the samples. In beach water samples from Lake Balaton we measured 0.076-0.233 E2 and n.d.-0.133 EE2. A relative high amount of EE2 was found in river Zala (0.68 ng/L) and in Hévíz-Páhoki canal (0.52 ng/L), which are both in the catchment area of Lake Balaton (Hungary). HighlightsMethod is proposed for simultaneous determination of 17β-estradiol and 17α-ethinyl estradiol. Derivatization is necessary to reach low LOQ. Low ng/L presence of estrogens in selected European Rivers has been detected.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

Avar

Zrínyi²,

Maász

et al. 2016

Environ Sci Pollut Res

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“…As the analytical capacity has improved in order to allow the quantification of very low concentrations (e.g. in the ng L −1 range) with the high degree of certainty given by the use of tandem mass spectrometry, scientists have been able to quantify these xenobi-otics in the aquatic systems (surface waters, ground waters, treated and untreated wastewaters and even tap waters) (Loos et al, 2010(Loos et al, , 2013a.…”

Section: Introductionmentioning

confidence: 99%

Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk

Lolić

Paíga

Santos

et al. 2015

Science of The Total Environment

178

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A B S T R A C TThe occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples covering fourteen beaches and five cities were evaluated in order to assess the spatial distribution of pharmaceuticals among north Portuguese coast. Seawaters were selected in order to embrace different bathing water quality (excellent, good and sufficient). Acetaminophen, ketoprofen and the metabolite hydroxyibuprofen were detected in all the seawater samples at maximum concentrations of 584, 89.7 and 287 ng L −1 , respectively. Carboxyibuprofen had the highest seawater concentration (1227 ng L −1 ). The temporal distribution of the selected pharmaceuticals during the bathing season showed that, in general, higher concentrations were detected in August and Septem-ber. The environmental risk posed by the pharmaceuticals detected in seawaters towards different trophic levels (fish, daphnids and algae) was also assessed. Only diclofenac showed hazard quotients above one for fish, representing a potential risk for aquatic organisms. These results were observed in seawaters classified as excellent bathing water. Additional data is needed in order to support the identification and prioritization of risks posed by pharmaceuticals in marine environment.

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“…These precursor inputs take into account the appearing of 26 NP 1 EC or NP 1 EO along the studied transect due to the biodegradation of long chain compounds and they are 1 expressed in nanogram per litter of water and per day (ng/L/d). 2 The scheme in Fig. 3 shows the layout and input parameters of the model.…”

Section: Equationmentioning

confidence: 99%

“…The difficulty to assess the NPnEO concentrations and their biodegradation 27 relies in the fact that there is a lack of commercial pure reference standards which can be used for a reliable 28 analysis, and that various commercial mixtures exist with different chain lengths according to their use 1 (Ayorinde et al, 1999). 2 To date, only one study focuses on the determination of in-situ attenuation rate constants of NPnEO and 4-NP 3 based on a hydrodynamic and biogeochemical model (Jonkers et al, 2005). However, these attenuation rate 4 constants have to be confirmed since: 5 i)…”

Section: Introductionmentioning

confidence: 99%

Modelling the fate of nonylphenolic compounds in the Seine River — part 1: Determination of in-situ attenuation rate constants

Cladière

Bonhomme

Vilmin

et al. 2014

Science of The Total Environment

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Occurrence of polar organic contaminants in the dissolved water phase of the Danube River and its major tributaries using SPE-LC-MS2 analysis

Cited by 195 publications

References 36 publications

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk

Modelling the fate of nonylphenolic compounds in the Seine River — part 1: Determination of in-situ attenuation rate constants

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