Occurrence of spleen qi deficiency as defined by Chinese medicine in Parkinson disease

Chua, Ka-Kit; Li, Min

doi:10.1016/j.jtcms.2017.03.002

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…These causes lead to insufficient nourishment to sinews and meridians in the extremities [ 10 ]. Our previous research also discovered that a large portion of PD patients had “Deficiency of Spleen Qi” (DSQ) [ 11 ]. The treatment strategy will be to reinvigorate internal organs and nourish meridians [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Conduction Exercise and Self‐Acupressure in Treatment of Parkinson’s Disease: A Pilot Study

Yuen

Chua

Lau

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Introduction. Parkinson’s disease cannot be well treated by conventional medication. Acupuncture and Tai Chi are proven to be effective in relieving symptoms of Parkinson’s disease. Traditional Chinese medicine exercises may prove to be an effective complementary therapy. Objective. To evaluate the efficacy and safety of conduction exercise and self-acupressure in treating Parkinson’s disease. Method. This study is an accessor- and data analyzer-blind, add-on, randomized, controlled, pilot clinical study. In the treatment group, they were taught to practice conduction exercise and self-acupressure for 8 weeks. No additional treatment was given in the control group. Assessments were done at week 4 and week 8 of the treatment period. The primary outcomes are the total score and domain scores of the Chinese version of 39-item Parkinson’s Disease Questionnaire. The secondary outcomes are the total score and domain scores of a custom-designed questionnaire, which is a short form of Nonmotor Symptom Scale. Results. 22 patients in the treatment group and 14 in the control group continued to the treatment phase. Patients in the treatment group displayed improvement trends in primary and secondary outcomes. Improvements were significant in two areas of a custom-designed questionnaire: total score (p=0.014) and domain score of gastrointestinal tract (p=0.004). No severe adverse events were reported. Conclusion. Conduction exercise and self-acupressure were well accepted by and feasible for Parkinson’s disease patients. The data generated can be used for the planning of future studies. The exercise regime can be promoted as a home-based, self-practice therapy for Parkinson’s disease patients, due to its safety, low cost, and convenience in implementation. This study is registered with the Chinese Clinical Trial Registry (ChiCTR-IPR-17011987, on 14 July 2017).

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Section: Introductionmentioning

confidence: 99%

The Effect of Conduction Exercise and Self‐Acupressure in Treatment of Parkinson’s Disease: A Pilot Study

Yuen

Chua

Lau

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Moreover, our group investigated corynoxine (Cory), another active compound isolated from Gouteng, and found that it can promote the clearance of α -syn via Akt/mTOR (Akt murine thymoma viral oncogene homolog 1, Akt; mammalian target of rapamycin, mTOR) pathway [ 16 ]. We also found that more than 90% of PD patients are having DSQ [ 17 ]. JLT may be suitable for most PD patients if it is workable.…”

Section: Introductionmentioning

confidence: 99%

A Randomized Controlled Trial of Chinese Medicine on Nonmotor Symptoms in Parkinson’s Disease

Chua

Wong

Chan

et al. 2017

Parkinson's Disease

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Nonmotor symptoms (NMS) of Parkinson's disease (PD) have devastating impacts on both patients and their caregivers. Jiawei-Liujunzi Tang (JLT) has been used to treat some NMS of PD based on the Chinese medicine theory since Qing dynasty. Here we report a double-blind, randomized, placebo-controlled, add-on clinical trial aiming at evaluating the efficacy and safety of the JLT in treating NMS in PD patients. We randomly assigned 111 patients with idiopathic PD to receive either JLT or placebo for 32 weeks. Outcome measures were baseline to week 32 changes in Movement Disorder Society-Sponsored Revision of Unified PD Rating Scale (MDS-UPDRS) Parts I–IV and in NMS assessment scale for PD (NMSS). We observed improvements in the NMSS total score (p = 0.019), mood/cognition (p = 0.005), and reduction in hallucinations (p = 0.024). In addition, post hoc analysis showed a significant reduction in constipation (p < 0.001). However, there was no evidence of improvement in MDS-UPDRS Part I total score (p = 0.216) at week 32. Adverse events (AEs) were mild and comparable between the two groups. In conclusion, long-term administration of JLT is well tolerated and shows significant benefits in improving NMS including mood, cognition, and constipation.

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The effect of conduction exercise and self-acupressure in treatment of Parkinson's disease: Protocol for a pilot study

Yuen

Chua

Lau

et al. 2019

Journal of Traditional Chinese Medical Sciences

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Occurrence of spleen qi deficiency as defined by Chinese medicine in Parkinson disease

Cited by 3 publications

References 19 publications

The Effect of Conduction Exercise and Self‐Acupressure in Treatment of Parkinson’s Disease: A Pilot Study

The Effect of Conduction Exercise and Self‐Acupressure in Treatment of Parkinson’s Disease: A Pilot Study

A Randomized Controlled Trial of Chinese Medicine on Nonmotor Symptoms in Parkinson’s Disease

The effect of conduction exercise and self-acupressure in treatment of Parkinson's disease: Protocol for a pilot study

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