2000
DOI: 10.1128/aac.44.3.775-777.2000
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Occurrence of the New Tetracycline Resistance Gene tet (W) in Bacteria from the Human Gut

Abstract: Members of our group recently identified a new tetracycline resistance gene, tet(W), in three genera of rumen obligate anaerobes. Here, we show that tet(W) is also present in bacteria isolated from human feces. The tet(W) genes found in human Fusobacterium prausnitzii and Bifidobacterium longum isolates were more than 99.9% identical to those from a rumen isolate of Butyrivibrio fibrisolvens.The rapid increase in antibiotic resistance in human pathogenic bacteria is a major problem, particularly for nosocomial… Show more

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Cited by 127 publications
(116 citation statements)
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“…The different tet genes can have either the same mode of action (efflux or ribosomal protection), or different modes of action (efflux and ribosomal protection), just like the pathogenic and opportunistic species do (230). The carriage of multiple tet genes of different classes is commonly found in individual gram-positive isolates (37,236,266,267,307) and in Mycobacterium spp. and Streptomyces spp.…”
Section: Incidence Of Tetracycline Resistancementioning
confidence: 99%
See 1 more Smart Citation
“…The different tet genes can have either the same mode of action (efflux or ribosomal protection), or different modes of action (efflux and ribosomal protection), just like the pathogenic and opportunistic species do (230). The carriage of multiple tet genes of different classes is commonly found in individual gram-positive isolates (37,236,266,267,307) and in Mycobacterium spp. and Streptomyces spp.…”
Section: Incidence Of Tetracycline Resistancementioning
confidence: 99%
“…Based on information from references 8, 9, 11, 14, 19, 40, 45, 55, 58-61, 81, 94, 97, 104, 111, 115, 116, 120, 122, 132, 139, 143, 149, 151, 152, 155, 163, 168-170, 182, 189, 200, 201, 206, 224, 227, 232, 233, 234, 241, 248, 256, 262, 267, 280, 282, 296, 314, 317 (14,150,267).…”
Section: Genetic and Biochemical Mechanisms Of Tetracycline Resistancementioning
confidence: 99%
“…While it is not possible to determine the origin of resistance on the evaluated farms using molecular techniques, it can be determined whether there is resistant gene flow from one compartment to another (animal/environment). The method for tracking the flow of a gene based on nucleotide sequence similarity has been widely applied, as shown in studies by Jansen et al (1998), Scott et al (2000) and Aminov et al (2001). The sequence similarity among resistance genes detected in animal and environmental samples in this study, despite the fact the two compartments host different microbial communities (Figure 3), provides evidence of horizontal transfer through mobile genetic elements between these two compartments.…”
Section: Discussionmentioning
confidence: 67%
“…TetW genes found in isolates from three rumen genera, Butyrivibrio, Selenomonas and Mitsuokella share more than 99% base sequence identity, arguing for very rapid recent genetic exchange between them [2]. TetW genes have now been found in anaerobic bacteria from pigs and humans and again show remarkable sequence similarity to the original ruminal isolate [72]. The tetW product shows only 68% amino acid sequence homology with its closest relatives (tetM and tetO) among the products of ribosome protection type resistance genes [2].…”
Section: Bacterial Transformationmentioning
confidence: 98%