Occurrence of VIP nerves in mammal dental pulps

Uddman, Rolf; Björlin, G; Møller, Birger R.; Sundler, F.

doi:10.3109/00016358009033600

Cited by 65 publications

(26 citation statements)

References 17 publications

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“…It is reasonable to presume that ET in tooth represents an endothelium-derived peptide that may act in concert with previously identified neuropeptides in the regulation of local blood pressure and/or blood flow (Uddman et al 1980(Uddman et al , 1984(Uddman et al , 1986Edwall et al 1985;Gazelius et al 1987;Casasco et al 1990a, b).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical localization of endothelin-like immunoreactivity in human tooth germ and mature dental pulp

et al. 1991

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The distribution in oral tissues of endothelin, a multifunctional peptide originally identified within endothelial cells, and subsequently in some epithelial cells, neurons and neuroendocrine cells, has not been investigated yet. We have studied the localization of endothelin-like immunoreactivity in human tooth germ and mature dental pulp by immunohistochemical techniques. Such immunoreactivity was detected only within endothelial cells in both mature dental pulp and developing tooth. Arteries and veins of various sizes as well as small thin vessels displayed endothelin-like immunoreactivity. In the tooth germ, the cells of the enamel organ or the precursors of the odontoblasts were found unreactive. In the mature pulp, no cells of the stroma or nerves displayed endothelin-like immunoreactivity. These findings suggest that vascular endothelium may be the only source of endothelin in human dental tissues. It is tentatively proposed that endothelin released in mature tooth pulp may participate in the regulation of the pulpal blood flow. Although the possible role of endothelin in developing tissues is far from being clear, the mitogenic effects and the proto-oncogenes expression induced by endothelin in some cells raise the possibility that this peptide might also play a role during tooth development.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical localization of endothelin-like immunoreactivity in human tooth germ and mature dental pulp

et al. 1991

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“…VIP immunoreactivity is a marker for parasympathetic postganglionic neurons. VIP-containing nerve fibers have been found in dental pulp (57). In addition, intra-arterial injection of synthetic VIP causes vasodilation in the cat pulp (90), and denervation experiments demonstrated that VIP in the pulp of cats does not originate from sensory or sympathetic nerves (91).…”

Section: The Role Of Innervation and Neuropeptide Release In The Contmentioning

confidence: 98%

“…Although there are some controversies regarding parasympathetic innervation of the dental pulp, VIP is expressed in dental pulp neurons (57). VIP fibers travel along the large blood vessels and show a network-like arrangement adjacent to the blood vessel wall.…”

Section: Vipmentioning

confidence: 99%

Neuropeptides in Dental Pulp: The Silent Protagonists

Caviedes-Bucheli¹,

Muñoz²,

Azuero-Holguin³

et al. 2008

Journal of Endodontics

140

138

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“…8). Suarez-Quintanilla, 1988; Uddman et al, 1980;Wakisaka et al, 1987). The majority of morphological studies investigating the innervation of pulp vessels are histochemical studies, and using light microscopy alone, no definite conclusion can be drawn as to whether these nerves affect the vascular wall cells.…”

Section: Innervation Of Pulp Vesselsmentioning

confidence: 99%

Three‐dimensional wall structure and the innervation of dental pulp blood vessels

Iijima

Zhang

2002

Microscopy Res & Technique

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The involvement of neural components in plasma extravasation and blood flow in the dental pulp has been established by pharmacological and physiological studies. We review here the segmental constitution of pulp vessels and the possible involvement of neural components in both the contractility and permeability of the pulp vessels from a morphological viewpoint. Six vascular segments can be identified based on the morphology of peri-endothelial cells, such as smooth muscle cells and pericytes. These are: muscular arterioles, terminal arterioles, precapillary arterioles, capillaries, postcapillary venules, and collecting or muscular venules. The perivascular nerve forms a mesh with numerous terminal varicosities, some of which attach directly to arteriolar smooth muscle cells. This mesh can be seen by scanning electron microscopy, and indicates the important role of neural components in regulating the pulpal circulation. After administering norepinephrine (0.2 mg/kg/dog), the surface texture of the smooth muscle cells of pulp arterioles reveals marked irregularities, which are correlated with arteriolar contraction. The pericytes in larger postcapillary venules (diameter 20 microm or larger) also show irregularities, whereas no changes are seen in the pericytes of either smaller postcapillary venules or capillaries. The intercellular spaces of pericytes in the postcapillary venules are wide enough for leukocytes to pass through, and the occasional extravasation of leukocytes through venule walls can be seen under electron microscopy. The microvessels of healthy human dental pulp react weakly to selectins, indicating that apparently healthy dental pulp may be weakly inflamed. In rat dental pulp, CGRP-immunoreactive nerves and nerve terminals containing many granular vesicles supply the postcapillary venules more densely than the arterioles, which suggests the involvement of postcapillary venules in neurogenic inflammation in the dental pulp.

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Occurrence of VIP nerves in mammal dental pulps

Cited by 65 publications

References 17 publications

Immunohistochemical localization of endothelin-like immunoreactivity in human tooth germ and mature dental pulp

Immunohistochemical localization of endothelin-like immunoreactivity in human tooth germ and mature dental pulp

Neuropeptides in Dental Pulp: The Silent Protagonists

Three‐dimensional wall structure and the innervation of dental pulp blood vessels

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