Occurrence of volatile and non-volatile N-nitrosamines in processed meat products and the role of heat treatment

Herrmann, Susan Strange; Duedahl‐Olesen, Lene; Granby, Kit

doi:10.1016/j.foodcont.2014.05.030

Cited by 124 publications

(75 citation statements)

References 17 publications

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“…They developed an analytical method for simultaneous determination of volatile and non-volatile N-nitrosamines in meat products by liquid chromatography coupled with tandem mass spectrometric detection in a combination with atmospheric pressure chemical ionization and electrospray ionization (Herrmann et al, 2014). They monitored N-nitrososarcosine, N-nitrosohydroxyproline, N-nitrosoproline, N-nitroso-2-methyl-thiazolidine-4-carboxylic acid, and N-nitrosothiazolidine-4-carboxylic acid (NSAR, NHPRO, NPRO, NMTCA and NTCA) from the non-volatile group and studied the effect of some factors on resulting concentration of volatile and nonvolatile N-nitrosamines in meat products, such as the effect of temperature (Herrmann et al, 2015a) or amount of addend nitrite, erythorbic acid and ascorbyl palmitate as nitrosation inhibitors (Herrmann et al, 2015b).…”

Section: ■ ■ 3 Advances In Analysis Of N-nitrosaminesmentioning

confidence: 99%

“…Autoři studovali vlivy různých faktorů na výsledné koncentrace těkavých i netěkavých N-nitrosaminů v masných produktech, jako vliv teploty (Herrmann et al, 2015a) nebo množství přidaného dusitanu a erythorbové kyseliny a askorbil palmitátu jako inhibitorů nitrosace (Herrmann et al, 2015b).…”

Section: ■ ■ 4 Current Knowledge About the Properties Of N-nitroso Counclassified

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N-nitrosamines in 21<sup>th</sup> Century

Vrzal¹,

Olšovská²

2016

Kvasný Průmysl

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Erst in den 70er Jahren des zwanzigsten Jahrhunderts wurden erstmals die stickstoffhaltigen krebserregenden Stoffe benannte N-Nitrosamine beschrieben. Ihr bewährtes Gehalt im Bier in Zusammenhang mit einem Gefahrrisiko für die Menschengesundheit hat zur Entwicklung von neuen technischen Verfahren, insbesondere der Malzherstellung geführt. Nach ihrer Einführung ist wesentlich Gehalt an N-Nitrosamine im Malz und im Bier erniedrigt worden, aus diesem Grund ist in den letzten 15 Jahren sanken Interesse an der Forschung dieser Stoffe zum Minimum, trotzdem dass in dieser Problematik viele Fragen noch nicht erklärt wurden. Dieser Artikel ist zur kurzen historischen Übersicht der N-Nitrosaminen Problematik gewidmet und informiert über bedeutendste Fortschritte, die in den letzten 15 Jahren bei der Analyse dieser Verbindungen geschafft wurden.

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Section: ■ ■ 3 Advances In Analysis Of N-nitrosaminesmentioning

confidence: 99%

Section: ■ ■ 4 Current Knowledge About the Properties Of N-nitroso Counclassified

N-nitrosamines in 21<sup>th</sup> Century

Vrzal¹,

Olšovská²

2016

Kvasný Průmysl

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“…Humans and animals are exposed to N-nitrosamines through chemical industries, processed foods, ground water and polluted environment, giving rise to toxicological implications [1]. The toxicity of NDMA has been associated with free radicals, reactive metabolites and inflammatory substances [2].…”

Section: Introductionmentioning

confidence: 99%

Betulinic acid protects againstN-nitrosodimethylamine-induced redox imbalance in testes of rats

Adeleke

Adaramoye

2017

Redox Report

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Objectives: N-nitrosodimethylamine (NDMA) is known to elicit carcinogenic activity in the liver and kidney of animals. There is a dearth of information of its effect in testis. This study evaluated the protective role of betulinic acid (BA) against NDMA-induced redox imbalance in testes of rats. Methodology: Twenty-four male rats were assigned into four groups and treated with normal saline, BA, NDMA and [BA+NDMA]. BA (25 mg/kg) was given for 14 days, while NDMA (5 mg/kg) was given on days 7 and 12. Results: Administration of NDMA significantly increased the weight and relative weight of testes by 51 and 71%, respectively, while treatment with BA attenuated the weight-gain. Furthermore, NDMA decreased the sperm count, motility and live-dead ratio by 57, 36 and 37%, respectively, and increased total sperm abnormality by 56%. However, BA attenuated the changes in the spermiogram of NDMA-treated rats. NDMA significantly decreased the activities of antioxidative enzymes, follicle-stimulating and luteinizing hormones, while testicular levels of thiobarbituric acid reactive substances and total cholesterol were increased. Also, NDMA increased the activities of aniline hydroxylase and aminopyrine-N-demethylase. Supplementation with BA attenuated NDMAinduced alteration in these biochemical indices. Conclusion: BA protects against NDMA-induced redox imbalance via activation of antioxidative pathway.

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“…56,57 The first hint came in the early 1960s from Norway, when sheep died of liver toxicity after feeding nitrite-preserved herring meal. 57,58 The effect of nitrate, nitrite, and NOCs on human health has been a recurrent issue with respect to cancer [59][60][61][62] due to unawareness of the general population exposure to NOCs, namely, diethylnitrosamine (DEN), present in foods, beverages, tobacco smoke, 57,[63][64][65] drinking water, and industrial pollution. 66,67 Endogenous synthesis of NOCs are also mentioned for being responsible for 45%-75% of total exposure.…”

Section: Experimentally Induced Liver Tumorsmentioning

confidence: 99%

Animal models as a tool in hepatocellular carcinoma research: A Review

2017

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Cancer is the first cause of death in developed countries and the second in developing countries. Concerning the most frequent worldwide-diagnosed cancer, primary liver cancer represents approximately 4% of all new cancer cases diagnosed globally. However, among primary liver cancer, hepatocellular carcinoma is by far the most common histological subtype. Notwithstanding the health promotion and disease prevention campaigns, more than half a million new hepatocellular carcinoma cases are reported yearly, being estimated to growth continuously until 2020. Taking this scenario under consideration and the fact that some aspects concerning hepatocellular carcinoma evolution and metastasize process are still unknown, animal models assume a crucial role to understand this disease. The animal models have also provided the opportunity to screen new therapeutic strategies. The present review was supported on research and review papers aiming the complexity and often neglected chemically induced animal models in hepatocarcinogenesis research. Despite the ongoing debate, chemically induced animal models, namely, mice and rat, can provide unique valuable information on the biotransformation mechanisms against xenobiotics and apprehend the deleterious effects on DNA and cell proteins leading to carcinogenic development. In addition, taking under consideration that no model achieves all hepatocellular carcinoma research purposes, criteria to define the "ideal" animal model, depending on the researchers' approach, are also discussed in this review.

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Occurrence of volatile and non-volatile N-nitrosamines in processed meat products and the role of heat treatment

Cited by 124 publications

References 17 publications

N-nitrosamines in 21<sup>th</sup> Century

N-nitrosamines in 21<sup>th</sup> Century

Betulinic acid protects againstN-nitrosodimethylamine-induced redox imbalance in testes of rats

Animal models as a tool in hepatocellular carcinoma research: A Review

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