Ochratoxin A–induced genotoxic and epigenetic mechanisms lead to Alzheimer disease: its modulation with strategies

Niaz, Kamal; Shah, Syed Qaiser; Khan, Fazlullah; Bule, Mohammed Hussen

doi:10.1007/s11356-020-08991-y

Cited by 29 publications

(14 citation statements)

References 235 publications

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“…The mechanism of action is considered to be the inhibition of hepatic protein synthesis through competitive inhibition of phenylalanyl-t-RNAsynthetase with phenylalanine (Konrad and R€ oschenthaler, 1977;Creppy et al, 1979); however, renal leakage of albumin caused by kidney lesions is thought to be a possible contributor (Huff et al, 1988). The inhibitory effect of OTA on protein synthesis (Niaz et al, 2020) would be the cause of its immunosuppressive effect due to the depression of antibody responses and the impaired replacement of immune cells.…”

Section: Discussionmentioning

confidence: 99%

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Role of the glutathione redox system in the susceptibility of pheasants (Phasianus colchicus) to ochratoxin A

Fernye

Ancsin

Balogh

et al. 2021

AVet

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The purpose of the present study was to investigate the effects of different dietary concentrations of ochratoxin A (OTA) on the growth, feed intake, mortality, blood plasma protein content and some parameters of lipid peroxidation and the glutathione redox system of pheasant chicks in a three-week long trial. A total of 320 seven-day-old female pheasants were randomly assigned to four treatment groups (n = 40 in each), fed with a diet artificially contaminated with OTA [control (<0.02 mg/kg), 0.88 mg/kg, 1.14 mg/kg and 1.51 mg/kg] for 21 days (up to 28 days of age). The pheasant chicks were sacrificed at early (12, 24 and 72 h) and late (7, 14 and 21 days) stages of mycotoxin exposure to check the effect of OTA. Minimal feed refusal was found in the medium- and high-dose toxin groups (–9.8 and –7.9%, respectively), and body weight gain was nearly the same in all groups. The glutathione redox system was activated mainly in the liver, confirmed by significantly increased reduced glutathione content and glutathione peroxidase activity during the late phase of mycotoxin exposure and at a high-dose treatment. The results suggest that pheasants have low susceptibility to OTA, and activation of the glutathione redox system has importance in this tolerance.

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Section: Discussionmentioning

confidence: 99%

“…Besides its nephrotoxic properties, ochratoxin displays immunotoxicity (Al-Anati and Petzinger, 2006), and it is a potent inhibitor of protein synthesis (Niaz et al, 2020). Due to its long half-life, OTA also can accumulate in the food chain (Gupta, 2007).…”

Section: Introductionmentioning

confidence: 99%

Role of the glutathione redox system in the susceptibility of pheasants (Phasianus colchicus) to ochratoxin A

Fernye

Ancsin

Balogh

et al. 2021

AVet

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“…In 1993, based on demonstrated carcinogenicity in animal studies, IARC (International Agency for Research on Cancer) identified OTA as a possible human carcinogen and included this mycotoxin in group 2B [ 8 ]. OTA toxicity is presumably due to its direct genotoxic effect through DNA binding and/or epigenetic or non-genotoxic mechanisms [ 1 , 9 ]. Pharmacokinetic characteristics such as long half-life time (35–70 days), high affinity for proteins (particularly serum albumin), and multiple active compounds obtained through OTA metabolism facilitate even more bio-accumulation and detrimental effects on human health [ 1 , 2 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cell cultures experiments demonstrated that OTA increased apoptosis-related indices, mitochondrial dysfunction, mitochondria-dependent apoptosis activation, and interfered with cytokine pathways [ 9 , 16 ]. In HK-2 cells, OTA induced apoptosis through regulation of the PTEN/AKT signaling pathway via disrupting lipid raft formation [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

An Immunoenzymatic Method for the Determination of Ochratoxin A in Biological Liquids (Colostrum and Cow’s Milk)

Cuciureanu

Tuchiluş

Vartolomei

et al. 2021

Toxins

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Ochratoxins are mycotoxins that have been extensively studied lately due to the multiple toxic effects such as nephrotoxicity, hepatotoxicity, and carcinogenicity. These toxins contaminate plant and animal foods and after ingestion they reach into body fluids. The method of competitive direct enzyme immunoassay, in the solid phase, was validated through the determination of specific parameters (performance, linearity, recovery percentage, limit of detection, limit of quantification). The validated method was used to determine ochratoxin A in colostrum and cow’s milk. The method applied for the determination of ochratoxin A was linear for the concentration range of 0.0–0.5 ng/mL, the value for the regression coefficient (r) was 0.9838. Ochratoxin A was present in 91.67% of the colostrum and in 93.33% of cow’s milk samples. The linearity of the method, demonstrated for very low concentrations of analyte, the detection limit as well as the limit of quantification recommend the method for the determinations of micro-pollutants from foods, including biological fluids.

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“…The authors suggested that further epidemiological investigations are essential to reduce the progress of neurodegeneration. Niaz et al (2020) highlighted the underlying mechanisms of ochratoxin A regarding genotoxicity and epigenetic modulations that lead to Alzheimer's disease. The authors recommended several phytochemicals, drugs, and trace elements to attenuate ochratoxin A-mediated effects; however, further studies are necessary to understand the exact mechanisms.…”

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confidence: 99%

Environmental pollutants and the risk of neurological disorders

Aleya

2020

Environ Sci Pollut Res

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Ochratoxin A–induced genotoxic and epigenetic mechanisms lead to Alzheimer disease: its modulation with strategies

Cited by 29 publications

References 235 publications

Role of the glutathione redox system in the susceptibility of pheasants (Phasianus colchicus) to ochratoxin A

Role of the glutathione redox system in the susceptibility of pheasants (Phasianus colchicus) to ochratoxin A

An Immunoenzymatic Method for the Determination of Ochratoxin A in Biological Liquids (Colostrum and Cow’s Milk)

Environmental pollutants and the risk of neurological disorders

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