OCT imaging of skin cancer and other dermatological diseases

Mogensen, Mette; Thrane, Lars; Jørgensen, Thomas Martini; Andersen, Peter E.; Jemec, Gregor B. E.

doi:10.1002/jbio.200910020

Cited by 176 publications

(100 citation statements)

References 70 publications

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“…Feasibility of OCT for skin examinations has been proven in various dermatological studies [12][13][14][15], and functional OCT techniques which can provide additional information such as polarization and vasculature have been developed. Polarization-sensitive OCT (PS-OCT) provides polarization properties of tissues such as birefringence, and it is useful for distinguishing lesions from normal tissues if the normal ones have polarization properties.…”

Section: Introductionmentioning

confidence: 99%

Dermoscopy guided dark-field multi-functional optical coherence tomography

Kwon

Yoon

Kim

et al. 2017

Biomed. Opt. Express

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Dermoscopy is a skin surface microscopic technique allowing specular reflection free observation of the skin, and has been used to examine pigmented skin lesions. However, dermoscopy has limitations in providing depth information due to lack of 3D resolution. In order to overcome the limitations, we developed dermoscopy guided multi-functional optical coherence tomography (MF-OCT) providing both high-contrast superficial information and depth-resolved structural, birefringent, and vascular information of the skin simultaneously. Dermoscopy and MF-OCT were combined by using a dichroic mirror, and dark-field configuration was adapted for MF-OCT to reduce specular reflection. After characterization, dermoscopy guided MF-OCT was applied to several human skin lesions such as the scar, port-wine stain (PWS) as well as the normal skin for demonstration. Various features of the scar and PWS were elucidated by both dermoscopy and MF-OCT. Dermoscopy guided MF-OCT may be useful for evaluation and treatment monitoring of skin lesions in clinical applications. Reinhold, "The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study," Br. J. Dermatol. 173(2), 428-435 (2015). 28. A. J. Coleman, G. P. Penney, T. J. Richardson, A. Guyot, M. J. Choi, N. Sheth, E. Craythorne, A. Robson, and R. Mallipeddi, "Automated registration of optical coherence tomography and dermoscopy in the assessment of sub-clinical spread in basal cell carcinoma," Comput.

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Section: Introductionmentioning

confidence: 99%

Dermoscopy guided dark-field multi-functional optical coherence tomography

Kwon

Yoon

Kim

et al. 2017

Biomed. Opt. Express

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“…Previous studies demonstrate OCT images of BCC, SCC, and actinic keratoses (AK) and have correlated these findings with standard histology. [17][18][19][20][21][22][23][24][25] The ability of OCT to differentiate NMSC lesions from normal skin has also been assessed in the clinical setting using observer-blinded evaluation by dermatologists and pathologists. 26 To date, however, most of the clinical investigations in skin disease using OCT have used two-dimensional (2-D) images or relatively low resolution.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

et al. 2012

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Abstract. We investigate morphological differences in three-dimensional (3-D) images with cellular resolution between nonmelanoma skin cancer and normal skin using Gabor domain optical coherence microscopy. As a result, we show for the first time cellular optical coherence images of 3-D features differentiating cancerous skin from normal skin. In addition, in vivo volumetric images of normal skin from different anatomic locations are shown and compared.

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“…So, visual inspection of OCT images may be used to assess tissue morphology, which has been used in various fields, such as ophthalmology, dermatology, cardiology, dentistry, and cancer structure [6,7] . For example, several characteristics of OCT images can be used to differentiate between cancerous and normal tissues.…”

Section: Optical Coherence Tomography (Oct) Is a Low Coherencementioning

confidence: 99%

Optical Coherence Tomography for Quantitative Diagnosis in Nasopharyngeal carcinoma

Li¹

2017

J Nasopharyng Carcinoma

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Abstract:We tried to quantitatively diagnose the intrinsic differences in the optical properties of nasopharyngeal carcinoma from normal tissue by optical coherence tomography. The scattering coefficients and anisotropies are extracted by fitting the average a-scan attenuation curves based on the multiple scatter effect. The median scattering coefficients of epithelium are 2.2 mm −1 (IQR 1.5 to 2.5 mm −1 ) for normal versus 3.8 mm −1 (IQR 2.0 to 3.3 mm −1 ) for cancer tissue; of lamina propria are 2.9 mm −1 (IQR 1.5 to 2.5 mm −1 ) for normal versus 1.

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OCT imaging of skin cancer and other dermatological diseases

Cited by 176 publications

References 70 publications

Dermoscopy guided dark-field multi-functional optical coherence tomography

Dermoscopy guided dark-field multi-functional optical coherence tomography

Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

Optical Coherence Tomography for Quantitative Diagnosis in Nasopharyngeal carcinoma

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