Octacalcium phosphate collagen composite facilitates bone regeneration of large mandibular bone defect in humans

Abstract

Recently it was reported that the implantation of octacalcium phosphate (OCP) and collagen composite (OCP-collagen) was effective at promoting bone healing in small bone defects after cystectomy in humans. In addition, OCP-collagen promoted bone regeneration in a critical-sized bone defect of a rodent or canine model. In this study, OCP-collagen was implanted into a human mandibular bone defect with a longer axis of approximately 40 mm, which was diagnosed as a residual cyst with apical periodontitis. The amount of OCP-collagen implanted was about five times greater than the amounts implanted in previous clinical cases. Postoperative wound healing was satisfactory and no infection or allergic reactions occurred. The OCP-collagen-treated lesion was gradually filled with radio-opaque figures, and the alveolar region occupied the whole of the bone defect 12 months after implantation. This study suggests that OCP-collagen could be a useful bone substitute material for repairing large bone defects in humans that might not heal spontaneously. Copyright © 2015 John Wiley & Sons, Ltd.

First clinical application of octacalcium phosphate collagen composite on bone regeneration in maxillary sinus floor augmentation: A prospective, single‐arm, open‐label clinical trial

“…This study demonstrated the safety and efficacy of OCP/Col, as a primary endpoint, on bone regeneration in maxillary sinus floor augmentation, as did previous clinical studies on application in human extraction tooth cavities and oral cystic cavities. 6,16,17 No clinical complications such as significant infection, severe inflammation or pain were seen beside the usual course associated with surgery, sensory disorders, and abnormal bone resorption caused by OCP/Col. Likewise, no systemic complications were observed.…”

“…In addition, Kanda et al have shown that OCP/Col does not interfere with eruption of the following permanent tooth when OCP/Col is implanted after deciduous tooth extraction in a young canine model . Furthermore, OCP/Col has also proven to offer not only safety, but also efficacy in bone regeneration on clinical studies of application to human tooth extraction sockets and cystic cavities . Therefore, the demand of alveolar ridge augmentation (including maxillary sinus floor augmentation) is also increasing.…”

“…15 Furthermore, OCP/Col has also proven to offer not only safety, but also efficacy in bone regeneration on clinical studies of application to human tooth extraction sockets and cystic cavities. 6,16,17 Therefore, the demand of alveolar ridge augmentation (including maxillary sinus floor augmentation) is also increasing. Based on these researches above, a hypothesis that OCP/Col would be a suitable bone substitute for maxillary sinus floor augmentation is enabled to be proposed.…”

Single‐dose local administration of teriparatide with a octacalcium phosphate collagen composite enhances bone regeneration in a rodent critical‐sized calvarial defect

“…Moreover, OCP/Col is expected to enhance physiological bone remodeling, is easy to handle, and has excellent cost performance. After the confirmation of bone regeneration by OCP/Col in various canine bone defect models,10, 11, 12, 13 a doctor‐initiated clinical study was performed on tooth extraction sockets and cyst holes 14, 15. A sponsor‐initiated clinical trial was recently conducted and the commercialization of OCP/Col appears to be forthcoming.…”

“…After the confirmation of bone regeneration by OCP/Col in various canine bone defect models, [10][11][12][13] a doctor-initiated clinical study was performed on tooth extraction sockets and cyst holes. 14,15 A sponsorinitiated clinical trial was recently conducted and the commercialization of OCP/Col appears to be forthcoming. However, bone regeneration by OCP/Col alone has limited availability, and, thus, the development of more reliable bone regeneration is anticipated.…”