Octacalcium phosphate (OCP) collagen composites enhance bone healing in a dog tooth extraction socket model

Iibuchi, S.; Matsui, Kosuke; Kawai, Tadashi; Sasaki, Kazuo; Сузукі, Осаму; Kamakura, Shinji; Echigo, Seishi

doi:10.1016/j.ijom.2009.12.006

Cited by 30 publications

(33 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kamakura et al developed a composite sponge constructed of OCP and porcine atelocollagen (OCP/collagen) and showed that OCP/collagen sponge significantly enhanced bone regeneration more than the implantation of OCP alone, β -TCP/collagen composite, or HAp/collagen composite, when implanted into a critical-sized calvarial defect rat model [51]. Moreover, the efficacy of bone regeneration by OCP/collagen sponge was confirmed in various canine bone defect models [53–56]. The results of the clinical trials are expected.…”

Section: Scaffolds For Acellular Bone Tissue Engineeringmentioning

confidence: 99%

Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications

Kinoshita

Maeda

2013

The Scientific World Journal

View full text Add to dashboard Cite

Autogenous bone grafting remains a gold standard for the reconstruction critical-sized bone defects in the craniomaxillofacial region. Nevertheless, this graft procedure has several disadvantages such as restricted availability, donor-site morbidity, and limitations in regard to fully restoring the complicated three-dimensional structures in the craniomaxillofacial bone. The ultimate goal of craniomaxillofacial bone reconstruction is the regeneration of the physiological bone that simultaneously fulfills both morphological and functional restorations. Developments of tissue engineering in the last two decades have brought such a goal closer to reality. In bone tissue engineering, the scaffolds are fundamental, elemental and mesenchymal stem cells/osteoprogenitor cells and bioactive factors. A variety of scaffolds have been developed and used as spacemakers, biodegradable bone substitutes for transplanting to the new bone, matrices of drug delivery system, or supporting structures enhancing adhesion, proliferation, and matrix production of seeded cells according to the circumstances of the bone defects. However, scaffolds to be clinically completely satisfied have not been developed yet. Development of more functional scaffolds is required to be applied widely to cranio-maxillofacial bone defects. This paper reviews recent trends of scaffolds for crania-maxillofacial bone tissue engineering, including our studies.

show abstract

Section: Scaffolds For Acellular Bone Tissue Engineeringmentioning

confidence: 99%

Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications

Kinoshita

Maeda

2013

The Scientific World Journal

View full text Add to dashboard Cite

show abstract

“…[742][743][744]783,[785][786][787][788] These biomaterials mimic natural bones to some extent, while their subsequent biological evaluation suggests that they are readily incorporated into the bone metabolism in a way similar to bone remodeling instead of acting as permanent implant. 609,731 However, the performance of these biocomposites depends on the source of the collagen from which it was processed.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Dorozhkin¹

2011

Biomatter

156

View full text Add to dashboard Cite

show abstract

“…Pre‐clinical studies have demonstrated outstanding outcomes for bone regeneration using OCP/Col in canine bone defect models . In addition, Kanda et al have shown that OCP/Col does not interfere with eruption of the following permanent tooth when OCP/Col is implanted after deciduous tooth extraction in a young canine model .…”

Section: Introductionmentioning

confidence: 99%

First clinical application of octacalcium phosphate collagen composite on bone regeneration in maxillary sinus floor augmentation: A prospective, single‐arm, open‐label clinical trial

et al. 2019

View full text Add to dashboard Cite

The overall objective of this study was to assess the safety and efficacy of OCP/Col as a bone substitute material for bone regeneration during sinus floor augmentation. Maxillary sinus floor augmentation was performed thorough lateral window approach. According to the height of host bone, simultaneous approach (≥5 mm) or staged approach (less than 5 mm) was applied. In this research, clinical findings of dental implant treatment after setting the restorations were set as a primary endpoint in both approaches (infection, inflammation around the implant, movement of the implant, pain, sensory disorder, and bone resorption around the implant body on radiological evaluation.). In staged approach, histological evaluation of bone biopsy specimen was also conducted. As secondary endpoints, hounsfield unit (HU) value, vertical bone height, implant stability quotient (ISQ), and adverse events during the research were evaluated. In all cases, as a primary endpoint, clinical findings after setting the restorations were uneventful with no adverse events. Histological structure demonstrated mature bone derived from OCP/Col. In the ossified area, osteogenesis was observed around OCP granules, and osteoblast‐like cells were arrayed around OCP granules. Osteocyte encapsulation was recognized in the new bone. HU increased over time with both approaches. Vertical bone height significantly increased at 3 months postoperatively, and maintained during follow‐up. ISQ increased with both approaches. In particular, ISQ was significantly increased with the staged approach. This clinical trial demonstrated the safety and efficacy of OCP/Col for bone regeneration in maxillary sinus floor augmentation. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:243–252, 2020.

show abstract

Octacalcium phosphate (OCP) collagen composites enhance bone healing in a dog tooth extraction socket model

Cited by 30 publications

References 25 publications

Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications

Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications

Biocomposites and hybrid biomaterials based on calcium orthophosphates

First clinical application of octacalcium phosphate collagen composite on bone regeneration in maxillary sinus floor augmentation: A prospective, single‐arm, open‐label clinical trial

Contact Info

Product

Resources

About