Octanoic acid potentiates glucose-stimulated insulin secretion and expression of glucokinase through the olfactory receptor in pancreatic β-cells

Leem, Jaechan; Shim, Hae-Min; Cho, Ho-Chan; Park, Jae-Hyung

doi:10.1016/j.bbrc.2018.06.015

Cited by 23 publications

(23 citation statements)

References 26 publications

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“…In chicken hepatocytes, caprylate has been shown to reduce secretion of apolipoprotein B, a component of low density cholesterol particles [86], reduce VLDL-cholesterol synthesis [89], and inhibit FA synthase activity, a key enzyme in de novo lipogenesis [85]. Caprylic acid has been documented to enhance glucose-stimulated insulin secretion [90], and two recent studies indicate that caprylic acid can induce this response in a dose-dependent manner [91,92]. Moreover, in mechanistic studies using a murine β-cell line (MIN6), these effects of caprylic acid on insulin secretion are likely mediated by the olfactory receptor OLFR15 via the phospholipase C-inositol triphosphate-dependent pathway [91,92].…”

Section: Potential Mechanisms Driving Differential Effects Of Sfa mentioning

confidence: 99%

“…Caprylic acid has been documented to enhance glucose-stimulated insulin secretion [90], and two recent studies indicate that caprylic acid can induce this response in a dose-dependent manner [91,92]. Moreover, in mechanistic studies using a murine β-cell line (MIN6), these effects of caprylic acid on insulin secretion are likely mediated by the olfactory receptor OLFR15 via the phospholipase C-inositol triphosphate-dependent pathway [91,92]. Thus, research suggests that caprylic acid intake may beneficially influence glucose and energy homeostasis.…”

Section: Potential Mechanisms Driving Differential Effects Of Sfa mentioning

confidence: 99%

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Dairy Fat Consumption and the Risk of Metabolic Syndrome: An Examination of the Saturated Fatty Acids in Dairy

2019

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Lifestyle is a key modifiable risk factor involved in the manifestation of metabolic syndrome and, in particular, diet plays a pivotal role in its prevention and development. Current dietary guidelines discourage the consumption of saturated fat and dietary sources rich in saturated fat, such as dairy products, despite data suggesting that full-fat dairy consumption is protective against metabolic syndrome. This narrative review assessed the recent epidemiological and clinical research that examined the consumption of dairy-derived saturated fatty acids (SFA) on metabolic syndrome risk. In addition, this review evaluated studies of individual SFA to gain insight into the potential mechanisms at play with intake of a diet enriched with these dairy-derived fatty acids. This work underscores that SFA are a heterogenous class of fatty acids that can differ considerably in their biological activity within the body depending on their length and specific chemical structure. In summary, previous work on the impact of dairy-derived SFA consumption on disease risk suggests that there is currently insufficient evidence to support current dietary guidelines which consolidate all dietary SFA into a single group of nutrients whose consumption should be reduced, regardless of dietary source, food matrix, and composition.

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Section: Potential Mechanisms Driving Differential Effects Of Sfa mentioning

confidence: 99%

Section: Potential Mechanisms Driving Differential Effects Of Sfa mentioning

confidence: 99%

Dairy Fat Consumption and the Risk of Metabolic Syndrome: An Examination of the Saturated Fatty Acids in Dairy

2019

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“…In addition, a recent study revealed that ORs recognize SCFAs and MCFAs in many non-olfactory tissues [ 17 ]. Representative examples are Olfr78 [ 15 ], Olfr544 [ 46 ], and Olfr15 [ 47 48 ], which recognize SCFAs, dicarboxylic MCFAs, and MCFAs, respectively. A further study is required to identify the GPCR that recognizes free MCFAs in astrocytes.…”

Section: Discussionmentioning

confidence: 99%

Fatty Acid Increases cAMP-dependent Lactate and MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a G_αsProtein-coupled Receptor

Lee

Hong

et al. 2018

Exp Neurobiol

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Medium-chain fatty acids (MCFAs) are mostly generated from dietary triglycerides and can penetrate the blood-brain barrier. Astrocytes in the brain use MCFAs as an alternative energy source. In addition, MCFAs have various regulatory and signaling functions in astrocytes. However, it is unclear how astrocytes sense and take up MCFAs. This study demonstrates that decanoic acid (DA; C10), a saturated MCFA and a ligand of G αs protein-coupled receptors (G αs -GPCRs), is a signaling molecule in energy metabolism in primary astrocytes. cAMP synthesis and lactate release were increased via a putative G αs -GPCR and transmembrane adenylyl cyclase upon short-term treatment with DA. By contrast, monoamine oxidase B-dependent gamma-aminobutyric acid (GABA) synthesis was increased in primary cortical and hypothalamic astrocytes upon long-term treatment with DA. Thus, astrocytes respond to DA by synthesizing cAMP and releasing lactate upon short-term treatment, and by synthesizing and releasing GABA upon long-term treatment, similar to reactive astrocytes. Our data suggest that astrocytes in the brain play crucial roles in lipid-sensing via GPCRs and modulate neuronal metabolism or activity by releasing lactate via astrocyte-neuron lactate shuttle or GABA to influence neighboring neurons.

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“…Studies in ECs in intestinal organoids and pancreatic α-cells report the involvement of the Gα olf /s-adenylyl cyclase signaling cascade for fatty acid-induced 5-HT secretion and azelaic acid (nonanedioic acid)-mediated glucagon secretion, respectively [12,22]. However, alternative signaling cascades have been indicated for olfactory chemosensing in non-oral nasal tissues as well [8,20,21].…”

Section: Fatty Acid Sensing Receptors Expressed On Eecs and Ecsmentioning

confidence: 99%

“…Meanwhile, it has become clear that functional ORs are expressed in many non-olfactory tissues including testis, prostate, kidney, adipose tissue, muscle, skin, hair, immune cells, heart, pancreas [2][3][4][5][6][7][8], and the GI tract [9][10][11][12][13][14][15]. Here, they play a role in diverse physiological processes varying from sperm chemotaxis, modulation of cancer cell proliferation, blood pressure regulation and immune cell migration to adiposity, gut hormone release, and modulation of energy-and insulin metabolism [3,5,9,14,[16][17][18][19][20][21][22]. Throughout Molecules 2021, 26, 1416 2 of 22 the body they act as chemosensors for endogenous molecules that have only partly been identified thus far.…”

Section: Introductionmentioning

confidence: 99%

The Intestinal Fatty Acid-Enteroendocrine Interplay, Emerging Roles for Olfactory Signaling and Serotonin Conjugates

Meijerink

2021

Molecules

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Intestinal enteroendocrine cells (EECs) respond to fatty acids from dietary and microbial origin by releasing neurotransmitters and hormones with various paracrine and endocrine functions. Much has become known about the underlying signaling mechanisms, including the involvement of G-protein coupled receptors (GPCRs), like free fatty acids receptors (FFARs). This review focusses on two more recently emerging research lines: the roles of odorant receptors (ORs), and those of fatty acid conjugates in gut. Odorant receptors belong to a large family of GPCRs with functional roles that only lately have shown to reach beyond the nasal-oral cavity. In the intestinal tract, ORs are expressed on serotonin (5-HT) and glucagon-like-peptide-1 (GLP-1) producing enterochromaffin and enteroendocrine L cells, respectively. There, they appear to function as chemosensors of microbiologically produced short-, and branched-chain fatty acids. Another mechanism of fatty acid signaling in the intestine occurs via their conjugates. Among them, conjugates of unsaturated long chain fatty acids and acetate with 5-HT, N-acyl serotonins have recently emerged as mediators with immune-modulatory effects. In this review, novel findings in mechanisms and molecular players involved in intestinal fatty acid biology are highlighted and their potential relevance for EEC-mediated signaling to the pancreas, immune system, and brain is discussed.

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Octanoic acid potentiates glucose-stimulated insulin secretion and expression of glucokinase through the olfactory receptor in pancreatic β-cells

Cited by 23 publications

References 26 publications

Dairy Fat Consumption and the Risk of Metabolic Syndrome: An Examination of the Saturated Fatty Acids in Dairy

Dairy Fat Consumption and the Risk of Metabolic Syndrome: An Examination of the Saturated Fatty Acids in Dairy

Fatty Acid Increases cAMP-dependent Lactate and MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a G_αsProtein-coupled Receptor

The Intestinal Fatty Acid-Enteroendocrine Interplay, Emerging Roles for Olfactory Signaling and Serotonin Conjugates

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Octanoic acid potentiates glucose-stimulated insulin secretion and expression of glucokinase through the olfactory receptor in pancreatic β-cells

Cited by 23 publications

References 26 publications

Dairy Fat Consumption and the Risk of Metabolic Syndrome: An Examination of the Saturated Fatty Acids in Dairy

Dairy Fat Consumption and the Risk of Metabolic Syndrome: An Examination of the Saturated Fatty Acids in Dairy

Fatty Acid Increases cAMP-dependent Lactate and MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a GαsProtein-coupled Receptor

The Intestinal Fatty Acid-Enteroendocrine Interplay, Emerging Roles for Olfactory Signaling and Serotonin Conjugates

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Fatty Acid Increases cAMP-dependent Lactate and MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a G_αsProtein-coupled Receptor