Octopamine receptor agonists synergistically increase the selected pesticides’ toxicity in Rhopalosiphum padi: Perspectives for reducing pesticide use, emergence of resistant strains and environmental impacts

Applying molecular docking to pesticides

“…Pesticide residues and the toxic effects of pesticides on non-target organisms are also critical issues that need to be addressed, making the design and synthesis of new chemical pesticides urgent. [18][19][20][21][22][23][24][25][26][27][28][29] Compared with traditional methods of pesticide creation, virtual screening technology with molecular docking at its core can greatly improve the screening success rate for pesticide lead compounds and make up for the shortage of traditional pesticide creation methods, one of the important tools for pesticide research and development. For example, Vaidya and colleagues 30 used a GLIDE docking strategy to screen the abscisic acid receptor agonist Opabactin from the ZINC database.…”

“…In addition, with increased pesticide use, resistance in pests and weeds is becoming more and more serious. Pesticide residues and the toxic effects of pesticides on non‐target organisms are also critical issues that need to be addressed, making the design and synthesis of new chemical pesticides urgent 18–29 …”