Ocular and Cutaneous Manifestations of Puva Therapy — A Review

Lerman, Sidney; Megaw, Judith M.; Gardner, K; Drake, Lynn A.

doi:10.3109/15569528209079876

Cited by 7 publications

(2 citation statements)

References 37 publications

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“…Reports of changes in unprotected eyes of PUV A patients (WAGNER et al 1978;LERMAN et al 1983) are suggestive, but require confirmation. Reports of changes in unprotected eyes of PUV A patients (WAGNER et al 1978;LERMAN et al 1983) are suggestive, but require confirmation.…”

Section: Miscellaneous Cutaneous Toxicities Associated With Puv a Thementioning

confidence: 97%

Pharmacology of the Skin II

1989

Handbook of Experimental Pharmacology

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PrefaceThe recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology.We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.It was because of this burgeoning interest in pharmacology of skin and its diseases, that this book came about. Indeed it is long overdue and was planned several years ago; we console ourselves with the thought that the delay may have served to help define certain principles which were then only just emerging.The book is divided into two volumes which are independent but complementary; the first being an account of the general pharmacology of skin, the second volume being more concerned with disease and drugs. The first volume is divided into two parts, the one dealing with the pharmacology of skin systems and their control and the other with autocoids in normal and inflamed skin. This second volume has three parts; the first part deals with the methods of measurement which are becoming of increasing importance both in studying the pharmacological effects of drugs and the clinical pharmacology of skin; the second deals with toxicology in its widest sense -including metabolism and percutaneous absorption; and the third is an account both of specific drugs and the drugs used for specific diseases.

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Section: Miscellaneous Cutaneous Toxicities Associated With Puv a Thementioning

confidence: 97%

Pharmacology of the Skin II

1989

Handbook of Experimental Pharmacology

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“…This application has been accepted in the Recommendations by the World Health Or ganisation as an adequate technique to test anticataract drugs [54], Moreover, Scheimpflug photography was applied in several ocular safety studies. In our department picumast dihydrochloride, the HMG-CoA reductase inhibitors pravastatin and simvastatin as well as verapamil could be shown to be safe for the lens [55-58], Lerman et al [59] studied UV photochemical changes in the lens caused by PUVA therapy.…”

Section: Drug Efficiency and Drug Safety Studiesmentioning

confidence: 99%

Scheimpflug Photography in Clinical Ohthalmology

Müller-Breitenkamp¹,

Hockwin²

1992

Ophthalmic Res

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The development of a slitlamp camera system based on the Scheimpflug principle with image analysis has been a major improvement in lens and cataract research. Since its introduction into ophthalmology by Brown and Niesel in the sixties of this century and further technical amelioration by Hockwin, Dragomirescu and Sasaki it has been applied in various experimental and clinical investigations. The purpose of this paper is to summarize and review the application of Scheimpflug photography in clinical ophthalmology and to show possibilities and indications for the use of the Scheimpflug technique in clinical studies.

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