Of the 3 million or so fibres that enter the primate brain, two-thirds originate within the eyes (Weiskrantz, 1972) (Kestenbaum, 1946; Cogan, I948; Walsh, I947; Walsh and Hoyt, I969), but necessitated some understanding of the commensurate advances in neuro-anatomy, neuro-pharmacology, visual physiology, and biomedical engineering. This review will attempt to align some of the information and concepts established by these basic disciplines and harness them for use by the clinical ophthalmologist. The first part will be confined to the visual sensory system and the second to the oculo-motor system.
Sensory systemThe visual process commences at a retinal level, where I 30 million light-sensitive receptors in each eye initiate a neural process terminating in the brain, where intricate analysis produces a three-dimensional picture which is related to past experience and includes colour, form, and rate of movement. Understanding of this organization began when Kuffler (I953) at the Johns Hopkins Hospital discovered that some analysis of visual information occurred in the retina of cats. The area of receptor mosaic in the retina feeding into a single visual cell is the receptive field of the cell. This fundamental concept was established by Hartline (I940) and utilized in the visual system pre-eminently by two distinguished workers from Harvard University, H. Hubel and T. N. Wiesel. The method depends on a microelectrode recording from a solitary visual cell, which can record from the cell for prolonged periods without impairing function.
RETINAL ORGANIZATIONThe receptive fields of ganglion cells are made up of a circular central region concentric with a larger circular surround region which is antagonistic to the central area. The cell is classed as an "on centre" cell when a light projected on the central area produces a response, but if the light is shone on the antagonistic surround the response is inhibited and the surround is termed an "off surround". The other class of ganglion cell has an "off centre" with an "on surround". This organization tends to enhance contours and the "on" and"off" areas tend reciprocally to reinforce their respective actions (Bishop, I964). Extensive