Ocular complications in renal allograft recipients

Jahadi-Hosseini, Hamidreza; Rahmani, Bahram; Karbassi, Arsha; Mehrian, M; Medghalchi, Abdolreza

doi:10.1016/s0041-1345(02)03986-6

Cited by 16 publications

(7 citation statements)

References 7 publications

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“…In the present study the prevalence of ocular complications among pediatric patients following kidney transplantation was 17%. Ocular complications in adult renal graft recipients are associated with significant morbidity and occur in more than 50% of patients during follow‐up of a yr (1, 4). Although these complications are less common than in adults, ocular morbidity seems to be significant in children and adolescents, as it has a considerable impact on the development of their visual function.…”

Section: Discussionmentioning

confidence: 99%

“…Renal graft recipients are prone to various ophthalmological problems due to adverse effects of immunosuppressive therapy and a high incidence of HT and diabetes. Ocular manifestations following kidney transplantation include cataract formation, increased IOP, hypertensive and diabetic retinopathy, papilledema, optic nerve atrophy, and opportunistic infections such as CMV retinitis and neoplasms of the eyes including PTLD (1–6). The purpose of the present study is to assess ocular findings in pediatric renal graft recipients and to examine the relationship between their occurrence and various risk factors.…”

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confidence: 99%

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Ocular complications in children and adolescents following renal transplantation

Krause

Snir

Cleper

et al. 2010

Pediatric Transplantation

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Ocular complications after renal transplantation are common in adults. Nevertheless, data regarding these complications in children are insufficient. The purpose of the present study was to assess ocular morbidity in pediatric renal graft recipients. A retrospective observational study of 71 patients aged 11.2 +/- 5.5 yr was conducted. Mean duration of follow-up was 5.6 +/- 3.5 yr. A total of 16 ocular complications were found in 12 (17%) of the patients. Three patients suffered from more than one complication. Cataract was the most common finding (six patients, 8.4%) followed by swollen disk and hypertensive retinopathy in four patients (5.7%) each and increased intra-ocular pressure in two patients (3%). Mean time interval between transplantation and occurrence of first abnormal ocular finding was 37 +/- 34.5 months. The follow-up time was significantly longer in patients with ophthalmological problems than in those without complications (7.8 yr vs. 5.2 yr, p < 0.02). No statistically significant association was found between the occurrence of ocular complications and the age of the patients at transplantation, donor source, duration of dialysis prior to transplantation, previous corticosteroid therapy or presence of acute rejection episodes. The results of the study point to the importance of regular concurrent ophthalmological follow-up in pediatric renal graft recipients to reduce/prevent ocular morbidity.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Ocular complications in children and adolescents following renal transplantation

Krause

Snir

Cleper

et al. 2010

Pediatric Transplantation

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“…For end-stage solid organ disease, transplantation is a therapeutic option in a noteworthy number of patients. Abnormal ophthalmological findings after several types of transplantation occur in more than 50% of patients [ 1 – 3 ], and are caused by the combination of pre-existing disease and immunosuppressive regimen [ 4 ]. Fortunately, vision-threatening conditions are seldom observed after long-term follow-up [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Fortunately, vision-threatening conditions are seldom observed after long-term follow-up [ 5 ]. Up to 45% of the transplant patients develop typical steroid-induced bilateral posterior subcapsular cataract within the first year after transplantation [ 1 ]. Bilateral, open-angle glaucoma is detected in up to 7% of patients within the first year after transplantation, which may be caused by the use of systemic steroids [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Up to 45% of the transplant patients develop typical steroid-induced bilateral posterior subcapsular cataract within the first year after transplantation [ 1 ]. Bilateral, open-angle glaucoma is detected in up to 7% of patients within the first year after transplantation, which may be caused by the use of systemic steroids [ 1 ]. Little is known about transplantation complications in the posterior segment of the eye.…”

Section: Introductionmentioning

confidence: 99%

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Spectrum of retinal abnormalities in renal transplant patients using chronic low-dose steroids

Dijk

Soonawala

Rooth

et al. 2017

Graefes Arch Clin Exp Ophthalmol

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PurposeTo assess the ophthalmological characteristics of asymptomatic patients with a renal transplant on chronic low-dose steroids for at least the last 2 years prior to examination.MethodsCross-sectional study. All patients underwent an extensive ophthalmological examination.ResultsOf the 37 included patients [25 male, 12 female; 59 ± 11 years (range, 38–77 years)] ophthalmological phenotyping revealed abnormalities in 22 patients (59%). Findings characteristic for (subclinical) central serous chorioretinopathy were detected in ten patients (27%), including two patients with serous subretinal fluid in the macula. An epiretinal membrane of the macula was present in six patients (16%). Mean subfoveal choroidal thickness was significantly increased in patients with ophthalmological abnormalities, in comparison with patients without abnormalities.ConclusionsRetinal abnormalities are common in the majority of renal transplant patients using chronic low-dose steroids. These retinal changes may be associated with the renal disease and/or the effect of chronic steroid use on the choroid and retina.

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Post-transplant erythrocytosis-related maculopathy: successful management of hyperviscosity with phlebotomy

Khanduja

Takkar

Khanduja³

et al. 2017

Int Ophthalmol

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Ocular complications in renal allograft recipients

Cited by 16 publications

References 7 publications

Ocular complications in children and adolescents following renal transplantation

Ocular complications in children and adolescents following renal transplantation

Spectrum of retinal abnormalities in renal transplant patients using chronic low-dose steroids

Post-transplant erythrocytosis-related maculopathy: successful management of hyperviscosity with phlebotomy

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