Ocular features of the HLA-B27-positive seronegative spondyloarthropathies

Jhaj, Gurdeep; Kopplin, Laura J.

doi:10.1097/icu.0000000000000525

Cited by 15 publications

(12 citation statements)

References 63 publications

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“…Uveitis in patients with HLA-B27 positivity and those with AS typically manifests as unilateral or alternating bilateral episodes of recurrent acute anterior segment inflammation, characterized by limbal hyperemia, fine keratic precipitates, and marked cellular reaction manifesting as fibrin exudation, fibrinous clot, and hypopyon [85][86][87] (Figures 1, 2, and 3). Posterior segment manifestations, including vitritis (Figure 4), retinal edema, vasculitis, papillitis, and pars plana exudation, are also seen [85,86,88].…”

Section: Ocular Disease In Spondyloarthropathiesmentioning

confidence: 99%

“…The disease is 1.1 -2.5-fold more frequent in male individuals. Male sex is a predictor of more severe disease and more frequent relapses [85,86,90,93].…”

Section: Ocular Disease In Spondyloarthropathiesmentioning

confidence: 99%

“…The incidence of hypopyon among HLA-B27-positive patients is higher than that among HLA-B27-negative patients [94]. Studies have documented a higher frequency of hypopyon in SSpA-related uveitis than in Behçet's disease and other uveitides manifesting with hypopyon [85,86,96]. The incidence of hypopyon in HLA-B27-positive uveitis with or without SSpAs is 12 -15% [67,94].…”

Section: Ocular Disease In Spondyloarthropathiesmentioning

confidence: 99%

“…The incidence of hypopyon in HLA-B27-positive uveitis with or without SSpAs is 12 -15% [67,94]. However, regardless of the presence or severity of systemic disease, hypopyon is entirely associated with HLA-B27 positivity [86]. Several studies have reported other ocular features including vitritis, retinal vasculitis, macular edema, pars plana exudates, and papillitis [87,88,90,95,97].…”

Section: Ocular Disease In Spondyloarthropathiesmentioning

confidence: 99%

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Uveitis in spondyloarthropathies

Khan¹,

Khan²,

Shahzad³

2022

Med Hypothesis Discov Innov Optom

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Background: Uveitis is associated with several systemic disorders. It may be the initial presentation or manifestation of a systemic disease. It is the most common ocular complication and is sometimes the earliest manifestation of spondyloarthropathies. This study aimed to review the current literature on spondyloarthropathies and associated uveitis. Methods: A narrative review was performed using various combinations of the keywords spondyloarthropathies, seronegative spondylarthritis-related uveitis, and human leukocyte antigen-associated uveitis using PubMed/MEDLINE and Google Scholar from January 1, 2000, to September 30, 2022. We describe the disease mechanisms, genetics, and classification of spondyloarthropathies, the clinical patterns of their related ocular diseases, and the current modalities for the management of their ocular or systemic manifestations. Results: Seronegative spondyloarthropathies are a group of rheumatic disorders including ankylosing spondylitis, reactive arthritis, psoriatic arthritis, inflammatory bowel disease-related spondyloarthropathy, juvenile-onset spondyloarthritis, and undifferentiated spondyloarthritis. These are characterized by enthesitis in the absence of serum rheumatoid factor and have a strong association with human leukocyte antigen B27. The clinical courses and features of spondyloarthropathies are remarkably diverse. Ocular inflammation is common in spondyloarthropathies, often precedes the onset or diagnosis of systemic disease, and responds well to topical therapy. Timely diagnosis of systemic diseases may improve quality of life and help avoid ocular and skeletal complications. Recurrence of ocular inflammation is frequent; on occasion, it may be associated with etanercept administration. Conclusions: Eye care professionals should be able to recognize spondyloarthropathies, manage ocular disease, and collaborate with related specialties for modification of systemic treatment if associated with ocular complications. Timely referral and early management could attenuate or prevent ocular or systemic morbidities associated with spondyloarthropathies.

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Section: Ocular Disease In Spondyloarthropathiesmentioning

confidence: 99%

“…The disease is 1.1 -2.5-fold more frequent in male individuals. Male sex is a predictor of more severe disease and more frequent relapses [85,86,90,93].…”

Section: Ocular Disease In Spondyloarthropathiesmentioning

confidence: 99%

Section: Ocular Disease In Spondyloarthropathiesmentioning

confidence: 99%

Section: Ocular Disease In Spondyloarthropathiesmentioning

confidence: 99%

See 2 more Smart Citations

Uveitis in spondyloarthropathies

Khan¹,

Khan²,

Shahzad³

2022

Med Hypothesis Discov Innov Optom

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“…HLA-B27 positive ERA JIA patients are at increased risk compared with HLA-B27 negative [20,66]. Uveitis is also a common feature of adultonset SpA where the vast majority of patients are HLA-B27 positive [67], underscoring the aforementioned potential role for HLA-B27 in uveitis development.…”

Section: Human Leukocyte Antigen (Hla)mentioning

confidence: 99%

Juvenile Idiopathic Arthritis Associated Uveitis

et al. 2021

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Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease. The development of associated uveitis represents a significant risk for serious complications, including permanent loss of vision. Initiation of early treatment is important for controlling JIA-uveitis, but the disease can appear asymptomatically, making frequent screening procedures necessary for patients at risk. As our understanding of pathogenic drivers is currently incomplete, it is difficult to assess which JIA patients are at risk of developing uveitis. Identification of specific risk factors for JIA-associated uveitis is an important field of research, and in this review, we highlight the genomic, transcriptomic, and proteomic factors identified as potential uveitis risk factors in JIA, and discuss therapeutic strategies.

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Retinal Manifestations of the Rheumatic Diseases

Smith

Rihani

2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

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Ocular features of the HLA-B27-positive seronegative spondyloarthropathies

Cited by 15 publications

References 63 publications

Uveitis in spondyloarthropathies

Uveitis in spondyloarthropathies

Juvenile Idiopathic Arthritis Associated Uveitis

Retinal Manifestations of the Rheumatic Diseases

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