Ocular involvement is associated with HLA-B51 in Adamantiades–Behçet's disease

Krause, Lothar; Ak, Köhler; Altenburg, Andreas; Papoutsis, Nestor; Cc, Zouboulis; Pleyer, U; Stroux, Andrea; Mh, Foerster

doi:10.1038/eye.2008.177

Cited by 25 publications

(15 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[13][14][15][16] Results of these studies partially support our findings, but they have not examined whether patients smoke or not. Bilgin et al 2 have also reported that cystoid macular edema among current smoking patients with BD was significantly higher than nonsmoking patients, but smoking was inefficient on other ocular involvement.…”

Section: Discussionsupporting

confidence: 80%

Effects of Smoking and HLA-B51 on Clinical Manifestations in Behçet’s Disease: Retrospective Analysis of 209 Patients in a Turkish Population

2015

View full text Add to dashboard Cite

Objectives: This study aims to investigate the separate and cumulative effects of smoking and human leukocyte antigen (HLA)-B51 on the severity and clinical manifestations of Behçet's disease (BD). Patients and methods: A total of 209 patients (119 males, 90 females; mean age 42.97±10.44 years; range 23 to 75 years) with BD were included in this retrospective study. The severity and clinical manifestations of BD, smoking habits, and presence of HLA-B51 of patients were obtained from medical records. The severity of BD was evaluated with Behçet's Syndrome Activity Scale (BSAS). Relationship between smoking habits and presence of HLA-B51 with disease severity and clinical manifestations was investigated. Results: Presence of HLA-B51 was effective on BSAS, erythema nodosum (EN), articular, ocular and neurological involvements (p=0.001, p=0.011, p=0.013, p=0.001, p=0.038, respectively). Smoking was also effective on BSAS, EN, articular, ocular and neurological involvements (p=0.001, p=0.001, p=0.013, p=0.042, p=0.027, respectively). There was a strong association between positive HLA-B51 with smoking (p=0.004). Smoking and HLA-B51 were effective on articular involvement, smoking was effective on EN, and HLA-B51 and smoking were effective on ocular and neurological involvements (p=0. 039, p=0.040, p=0.001, p=0.028, p=0.037, respectively). Conclusion: Our findings indicate that smoking and HLA-B51 influence severity and systemic involvements of BD with a positive relationship in between. We recommend that smoking and HLA-B51 should be considered simultaneously in BD since this relationship may lead to incorrect inferences.

show abstract

Section: Discussionsupporting

confidence: 80%

Effects of Smoking and HLA-B51 on Clinical Manifestations in Behçet’s Disease: Retrospective Analysis of 209 Patients in a Turkish Population

2015

View full text Add to dashboard Cite

show abstract

“…HLA-B51 was associated with ocular involvement in ABD in our study, as we have described in detail before [29].…”

Section: Discussionmentioning

confidence: 54%

Ocular involvement in Adamantiades-Behçet’s disease in Berlin, Germany

Krause

Köhler

Altenburg

et al. 2008

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

show abstract

“…In fact, the clinical manifestations of BD show large patient to patient variation even within the same ethnic group, particularly with respect to the distribution of organ involvement. Furthermore, studies that have investigated the association between HLA-B*51 and certain clinical subsets have suffered from limited statistical power and produced conflicting results [27][28][29][30][31][32][33][34][35][36][37][38] (Table 2). Nevertheless, ocular and cutaneous involvements have been frequently associated with HLA-B*51 in those studies that have presented positive results [27][28][29][31][32][33][34][35].…”

Section: Hla-b*51mentioning

confidence: 99%

Behçet’s disease and genes within the major histocompatibility complex region

Song

Kang

2011

Mod Rheumatol

View full text Add to dashboard Cite

The role of genetic background in the development of Behçet's disease (BD) is best reflected by the strong association between HLA-B*51 and BD that has been demonstrated across various ethnic groups. The contributions made by other HLA or non-HLA genes to disease susceptibility have been suggested by the results of a number of gene association studies, although the true associations between the genes located within the major histocompatibility complex (MHC) region and BD have often been doubted due to the possibility of linkage disequilibrium of those genes with HLA-B*51. The presence of a true susceptibility gene in the vicinity of HLA-B*51 has also been extensively investigated because of the limited evidence that directly relates HLA-B*51 to the pathogenesis of BD. However, recent genome-wide association studies have confirmed that HLA-B*51 is primarily associated with BD and that there are multiple susceptibility loci other than HLA-B*51. In this review, we discuss BD-associated genes within the MHC region and their biological roles in the pathogenesis of BD.

show abstract

Ocular involvement is associated with HLA-B51 in Adamantiades–Behçet's disease

Cited by 25 publications

References 33 publications

Effects of Smoking and HLA-B51 on Clinical Manifestations in Behçet’s Disease: Retrospective Analysis of 209 Patients in a Turkish Population

Effects of Smoking and HLA-B51 on Clinical Manifestations in Behçet’s Disease: Retrospective Analysis of 209 Patients in a Turkish Population

Ocular involvement in Adamantiades-Behçet’s disease in Berlin, Germany

Behçet’s disease and genes within the major histocompatibility complex region

Contact Info

Product

Resources

About