Ocular manifestations and complications of Stevens–Johnson syndrome and toxic epidermal necrolysis: an Asian series*

Abstract

Ocular involvement is common in SJS and TEN and can be severe and blinding. The severity of acute ocular complications does not predict late complications. The diagnosis of TEN does not imply a more severe ocular involvement or increased frequency of late ocular complications compared with SJS. Care should be taken even in mild cases. Appropriate intervention during acute ocular disease may prevent late complications.

The current understanding of Stevens–Johnson syndrome and toxic epidermal necrolysis

“…Severe blepharitis may lead to entropion with trichiasis (ingrowing eye lashes) causing further corneal damage. Various specialized approaches to ocular involvement have been suggested, such as stem cell generation of replacement cells, amniotic membrane transplantation and scleral lenses, but are not yet widely accepted [29,30]. Nevertheless, experienced ophthalmologists should be involved in the care of all patients with SJS/TEN, even those that do not present with eye-involvement right away, since it may occur with some delay.…”

Toxic Epidermal Necrolysis (Lyell’s Syndrome)

“…), ДВС-синдром, септицемия, са-харный диабет, гепатит, эктропион, энтропион, симблефарон, птеригиум, изъязвление роговицы [11][12][13][14][15].…”

Severe Cutaneous Adverse Reactions

“…The chronic ocular consequences are that of a cicatrization of the conjunctiva and symblepharon formation, severe dry eye, trichiasis, eyelid margin keratinization, and limbal stem cell deficiency, all of which combine to cause corneal ulceration and scarring and loss of vision (Fig. 5) [35], [36]. Patients may also experience chronic photophobia and eye pain [37].…”