Ocular Manifestations of Systemic Lupus Erythematosus

Cho, Heeyoon

doi:10.7599/hmr.2016.36.3.155

Cited by 4 publications

(6 citation statements)

References 34 publications

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“…Penyebab spesifik dari SLE masih belum diketahui dengan pasti, diduga banyak faktor predisposisi antara lain faktor genetik, mekanisme imun regulator, hormonal, dan faktor lingkungan. 17,18 Pada beberapa kasus, ADR dapat memicu terjadinya SJS dan SLE bersama-sama, namun hal ini jarang terjadi, 19 yang dapat menimbulkan efek pada tubuh salah satunya pada rongga mulut dan peri-oral yang bermanifestasi sebagai krusta dan lesi erosif luas, dapat mengganggu fungsi mulut sehingga asupan makanan terganggu dan juga dapat berpotensi mematikan. [20][21][22] Tujuan pembuatan laporan kasus ini untuk mengambarkan lesi oral pada pasien SJS disertai SLE yang dipicu obat dan mengindentifikasi secara dini serta cermat efek samping dari obat-obatan yang dapat menimbulkan SJS dan memicu SLE serta penanganan yang cepat untuk prognosis yang lebih baik.…”

Section: Pendahuluanunclassified

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Terapi lesi oral pasien sindrom Stevens-Johnson disertai lupus eritematosus sistemikOral lesion therapy in patients with Stevens-Johnson syndrome with systemic lupus erythematosus

Tamigoes

Dewi

2018

JKG

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ABSTRAKPendahuluan: Adverse drug reaction (ADR) merupakan salah satu respon tubuh manusia tidak diinginkan dan berbahaya yang disebabkan penggunaan obat meskipun dalam dosis normal. ADR dapat menyebabkan terjadinya sindrom Stevens-Johnson (SJS) serta dapat memicu lupus eritematosus sistemik (SLE), yang salah satu manisfestasinya sebagai krusta hemoragik dan erosi yang luas pada mulut dan peri-oral, dapat mengganggu fungsi mulut sehingga terganggunya asupan makanan. Laporan kasus ini bertujuan untuk menjelaskan terapi lesi oral pasien sindrom Stevens-Johnson disertai lupus eritematosus sistemik. Laporan kasus: Seorang pasien wanita berusia 57 tahun dengan riwayat penyakit meningitis tuberkulosis dirujuk ke Bagian Penyakit Mulut dari departemen Ilmu Kesehatan Kulit dan Kelamin dengan diagnosis SJS, pasien mengeluhkan kesulitan untuk membuka mulutnya, sakit menelan dan sakit pada bibir. Terdapat riwayat pemakaian obat ofloxacin, streptomysin, dan OAT. Pemeriksaan ekstraoral menunjukkan beberapa lesi diskret pada wajah, konjungtiva anemis, lesi erosif dan krusta hemoragik pada bibir. Pemeriksaan intraoral ditemukan lesi erosif pada mukosa bukal dan palatal serta plak putih pada dorsal lidah. Pemeriksaan darah rutin menunjukkan hemoglobin, hematokrit, leukosit, MCV, MCH, eosinofil, netrofil, limfosit, protein total dan albumin rendah sedangkan uji ANA positif, sehingga diagnosis ditegakkan sebagai lesi oral terkait SJS disertai SLE dan kandidiasis oral. Medikasi yang diberikan adalah Chlorhexidine gluconate 0,1%, nistatin suspensi oral, vitamin B12, asam folat, dan topikal kortikosteroid. Lesi oral menunjukkan perbaikan dalam waktu 3 minggu, pada pasien terjadi SJS dan SLE secara bersamaan hal ini menunjukkan adanya keterlibatan mekanisme imunologi Simpulan: Terapi non farmakologi berupa pemberian kortikosteroid topikal,obat kumur Chlorhexidine gluconate 0,1%, vitamin B12, asam folat, dan nistatin yang menunjukkan perbaikan pada lesi oral dalam 3 minggu perawatan, ditambah dengan terapi non farmakologi berupa pemeliharaan kebersihan rongga mulut dengan obat kumur Chlorhexidine gluconate 0,1% sebagai antiseptik untuk meningkatkan kenyamanan pasien, untuk memfasilitasi epitelisasi dan mencegah komplikasi seperti infeksi.Kata kunci: Adverse Drug Reaction, lesi oral, sindrom Stevens-Johnson, lupus eritematosus sistemik Oral lesion therapy in patients with Stevens-Johnson syndrome with systemic lupus erythematosus ABSTRACT Introduction: Adverse drug reaction (ADR) is one of the unwanted and dangerous human body responses caused by the use of medications even in regular doses. ADR can cause Stevens-Johnson syndrome (SJS) and trigger systemic lupus erythematosus (SLE), with manifestation such as extensive haemorrhagic and erosive crusts in the mouth and peri-oral, which can interfere the oral function and disrupt the food intake. This case report was aimed to explain the treatment of oral lesions in patients with Stevens-Johnson syndrome with systemic lupus erythematosus. Case report: A 57-years-old female patient with a his...

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Section: Pendahuluanunclassified

“…Faktor predisposisi SLE antara lain faktor genetik, imun regulator, hormonal, dan faktor lingkungan (obat-obatan, sinar matahari,virus). 17,18 Pada pasien ini ada riwayat asupan OAT kategori 1, ofloxacin, streptomycin, paracetamol sebelum pasien dirawat di rumah sakit, diduga memicu SLE.…”

Section: Berdasarkanunclassified

Terapi lesi oral pasien sindrom Stevens-Johnson disertai lupus eritematosus sistemikOral lesion therapy in patients with Stevens-Johnson syndrome with systemic lupus erythematosus

Tamigoes

Dewi

2018

JKG

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“…SLE is a potentially life-threatening multisystem disease that is commonly associated with ocular manifestations. The purpose of this review is to outline the ocular manifestations of SLE and treatments [3]. Ocular complications have been reported in up to one-third of patients with SLE.…”

Section: Systemic Lupus Erythematosus (Sle) Is An Autoimmune Diseasementioning

confidence: 99%

Ocular Manifestations of Systemic Diseases: The Eyes are the Windows of the Body

Cho

2016

Hanyang Med Rev

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“…Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) form part of a spectrum of rheumatic diseases, a varied group of chronic disorders, usually of an unknown aetiology that is associated with the presence of chronic inflammation, involving structures of the musculoskeletal system, blood vessels, and other tissues. [ 1 ] Ophthalmic manifestations are common[ 2 3 ] and may have diagnostic and prognostic implications. [ 4 ] Some ophthalmic manifestations present before systemic manifestations of the disease, others present during the active stage of the disease, whereas some of them are due to prolonged disease and/or medications used.…”

Section: Introductionmentioning

confidence: 99%

“…[ 4 ] Some ophthalmic manifestations present before systemic manifestations of the disease, others present during the active stage of the disease, whereas some of them are due to prolonged disease and/or medications used. [ 3 5 ] Some ophthalmic manifestations of rheumatic diseases such as peripheral ulcerative keratitis (PUK) and optic neuropathy could be potentially blinding. [ 6 ] Whereas other ophthalmic manifestations such as severe vaso-occlusive retinopathy may be an indication of threat to life itself.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Spectrum of Eye Disorders Among Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus in a Tertiary Hospital in Northern Nigeria

Muhammad

Abdullahi

Pam

et al. 2022

Journal of West African College of Surgeons

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Purpose: The aim of this study was to determine the spectrum of eye disorders in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Materials and Methods: A cross-sectional hospital-based study was conducted among 100 consecutive patients with RA and SLE. A semi-structured questionnaire was used to obtain details of patients’ sociodemographics, type of rheumatic disease, and prescribed medications. Each patient had a detailed examination of the anterior and posterior segments of the eye. Refraction, intraocular pressure measurement, Schirmer’s test, tear breakup time, gonioscopy, and dilated fundoscopy were also done. Fundus photograph, central visual field assessment, and optical coherence tomography were done as necessary. Analysis was done with the Statistical Package for Social Sciences (SPSS) version 25. Statistical significance was set at P < 0.05. Results: A total of 100 patients consisting of 74 RA and 26 SLE patients were evaluated. The female: male ratio was 4.3: 1 for RA, and all SLE patients were females. The prevalence of eye disorders was 42% in all patients; it was 41.9% and 42.3% among RA and SLE patients, respectively. The most common eye disorders were dry eye (38), refractive errors (18), and cataract (16). The mean age of RA patients with eye disorders (52.19 ± 16.17 years) was significantly higher than those without eye disorders (42.30 ± 13.14 years) ( P = 0.005). Conclusion: Eye disorders are common in RA and SLE. Comprehensive eye examination should be done on all RA and SLE patients at diagnosis and before commencement of medications, and patients should be referred promptly for evaluation when they have eye complaints.

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Ocular Manifestations of Systemic Lupus Erythematosus

Cited by 4 publications

References 34 publications

<p>Terapi lesi oral pasien sindrom Stevens-Johnson disertai lupus eritematosus sistemik</p><p>Oral lesion therapy in patients with Stevens-Johnson syndrome with systemic lupus erythematosus</p>

<p>Terapi lesi oral pasien sindrom Stevens-Johnson disertai lupus eritematosus sistemik</p><p>Oral lesion therapy in patients with Stevens-Johnson syndrome with systemic lupus erythematosus</p>

Ocular Manifestations of Systemic Diseases: The Eyes are the Windows of the Body

Prevalence and Spectrum of Eye Disorders Among Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus in a Tertiary Hospital in Northern Nigeria

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