Ocular rosacea: an under-recognized entity

Andreas, M.; Fabczak-Kubicka, Anna; Schwartz, Robert A.

doi:10.23736/s2784-8671.23.07484-4

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Similar to cutaneous rosacea, ocular rosacea is a clinical diagnosis based on signs and symptoms. Common eye manifestations include: dryness, blurred vision, foreign body sensation, burning/stinging, photophobia, blepharitis, meibomian gland dysfunction, and eyelid chalazion (6,26). In serious cases, rosacea can lead to vision loss through corneal inflammation, sclerokeratitis, and cicatricial conjunctivitis (6,27).…”

Section: Introductionmentioning

confidence: 99%

“…Primary research on rosacea often reports on cutaneous and ophthalmic manifestations, however, to the authors’ knowledge, there have been no reviews consolidating the literature through meta-analysis. There have, however, been narrative reviews and commentaries (26–28) published on ocular rosacea in the past few years, lending support to its clinical interest and importance. Therefore, identifying the prevalence of ocular rosacea in those with cutaneous rosacea is of clinical relevance.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of ocular manifestations in cutaneous rosacea: Protocol for a systematic review and meta-analysis

Nazzicone,

Kirkpatrick,

Biorac

et al. 2024

Preprint

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Introduction: Rosacea is a chronic inflammatory skin condition with concomitant ocular manifestations and neurogenic symptoms. Ocular rosacea poses a particular diagnostic challenge as its signs and symptoms often overlap with other ocular pathologies. Cutaneous and ocular rosacea present together in approximately 21-50% of patients, yet a solid understanding of comorbid ocular and cutaneous symptoms is lacking. Therefore, the present paper outlines a protocol for a systematic review and meta-analysis to describe and quantify the prevalence of ocular rosacea in cutaneous rosacea and each of its subtypes. Methods: This study will follow Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and be conducted using the systematic review software, Covidence. To determine inclusion, screening will occur at two levels (title and abstract-only followed by full-text) and will be completed separately by two authors. Primary research studies on ocular rosacea in adult cutaneous rosacea published in all languages and geographic regions until November 2023 will be reviewed for inclusion. Data pertaining to overall prevalence of ocular rosacea across and within cutaneous rosacea subtypes, mean age, sex, gender, ethnicity, socioeconomic status, time to diagnosis, time to treatment, and prevalence of comorbid conditions will be extracted. For each included study, the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework will be applied to assess study quality. Conclusion: To the authors' knowledge, this will be the first systematic review and meta-analysis comparing the prevalence of ocular rosacea in the various cutaneous subtypes in an adult population. By addressing this knowledge gap, this study aims to provide clear and easily interpretable data to aid in the early diagnosis and treatment of ocular rosacea. This study is registered in the International Prospective Register of Systematic Reviews (PROSPERO ID# CRD42023475026).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of ocular manifestations in cutaneous rosacea: Protocol for a systematic review and meta-analysis

Nazzicone,

Kirkpatrick,

Biorac

et al. 2024

Preprint

View full text Add to dashboard Cite

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The role of vitamins and nutrients in rosacea

Algarin,

Pulumati,

Jaalouk

et al. 2024

Arch Dermatol Res

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Rosacea is a common inflammatory skin condition displaying symptoms like flushing, erythema, papules, and pustules. Oral antibiotics, despite long-term adverse effects, are often used due to topical treatment limitations, underscoring the need for cost-effective choices like dietary modifications. Our review investigates the role of vitamins and minerals in rosacea, and provides evidence-based recommendations for supplementation and topical treatment of these nutrients for rosacea. An online search was performed on PubMed, Web of Science, Science Direct, Google Scholar, and ClinicalTrials.gov from 1998 to 2023. Included studies were summarized and assessed for quality and relevance in rosacea management. Varied outcomes emerged concerning the impact of essential vitamins and minerals on rosacea treatment. Vitamin A derivatives, specifically oral isotretinoin, demonstrated significant efficacy, with a 90% reduction in lesions, complete remission in 24% of patients, and marked improvement in 57% of patients. Vitamin B3 derivatives, such as topical 1-methylnicotinamide 0.25% and NADH 1%, improved symptoms in 76.4% (26/34) and 80% of patients, respectively. Outcomes for vitamin D, vitamin C, and zinc supplementation varied across studies. However, zinc sulfate solution 5% significantly reduced acne rosacea severity for patients with 40% and 60% exhibiting a moderate or good response, respectively. Omega-3 fatty acids showed significant improvement in alleviating xerophthalmia in 64% of patients with ocular rosacea. Vitamins and minerals hold potential in managing rosacea symptoms, offering a safe and cost-effective alternative or adjunctive treatment option. Currently, there are no established recommendations regarding their supplementation for rosacea. Studies assessing serum levels of vitamins and minerals in relation to rosacea are warranted, as this avenue holds potential for future advancements in the field.

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Rosacea in Older Adults and Pharmacologic Treatments

Lee,

Chien

2024

Drugs Aging

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Ocular rosacea: an under-recognized entity

Cited by 3 publications

References 38 publications

Prevalence of ocular manifestations in cutaneous rosacea: Protocol for a systematic review and meta-analysis

Prevalence of ocular manifestations in cutaneous rosacea: Protocol for a systematic review and meta-analysis

The role of vitamins and nutrients in rosacea

Rosacea in Older Adults and Pharmacologic Treatments

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