Ocular safety evaluation of blue light scleral cross-linking in vivo in rhesus macaques

Liu, Yu; Liu, Chong; Sun, Manyi; Lv, Xiaotong; Wang, Mengmeng; Jiao, Xuan; Zhang, Li; Wang, Ke; Zhang, Fengju

doi:10.1007/s00417-019-04346-7

Cited by 15 publications

(3 citation statements)

References 29 publications

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“…There were no significant differences in corneal endothelial counts between and within experimental eyes and control eyes at any of the follow-up time points. The results were consistent with our previous experiments [ 16 , 20 , 21 ], illustrating that scleral CXL did not affect basic ocular biological parameters of pathologically blind eyes. Retinoschisis was improved, while CNV fibrosis and retinal and choroidal atrophy were unchanged after scleral CXL.…”

Section: Discussionsupporting

confidence: 93%

Clinical Feasibility and Safety of Scleral Collagen Cross-Linking by Riboflavin and Ultraviolet A in Pathological Myopia Blindness: A Pilot Study

Sun

et al. 2022

Ophthalmol Ther

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Introduction To investigate the feasibility and safety of scleral ultraviolet A (UVA) cross-linking (scleral CXL) on pathologically blindness. Methods This was a prospective, observational clinical study. Five patients with monocular blindness due to pathological myopic maculopathy were enrolled. Eyes with best corrected visual acuity (BCVA) under 0.05 were defined as experimental eyes. The fellow eyes were defined as control eyes. Patients first underwent posterior scleral reinforcement (PSR) surgery in the control eye. Thereafter, scleral CXL surgery was performed in the experimental eye on the same day. Visual acuity, BCVA, slit lamp biomicroscopic examination, intraocular pressure measurement, corneal specula microscopies, axis length measurement, funduscopy with pupil dilation, color fundus photography, full-field flash electroretinography, optical coherence tomography, and color Doppler flow imaging were performed at baseline, 1 week, 1 month, 3 months, 6 months, and 12 months after surgery. Results No signs of inflammation were observed after operation and throughout the follow-up period. Retinoschisis was improved, while choroidal neovascularization fibrosis and retinal and choroidal atrophy were unchanged after scleral CXL. There were no statistically significant differences in the ophthalmic artery, central retinal artery, and posterior ciliary artery parameters of color Doppler flow imaging or in retinal thickness, within experimental and control eyes, at baseline, 1 week, 1 month, 3 months, or 12 months ( P > 0.05). Conclusions This pilot study verified the feasibility and safety of scleral CXL on human blindness. The UVA-CXL on the sclera of human eyes seems to have the same effect as PSR in preventing progressive pathological myopia in the future. Trial Registration Chinese Clinical Trial Registry (ChiCTR2100042422).

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Section: Discussionsupporting

confidence: 93%

Clinical Feasibility and Safety of Scleral Collagen Cross-Linking by Riboflavin and Ultraviolet A in Pathological Myopia Blindness: A Pilot Study

Sun

et al. 2022

Ophthalmol Ther

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“…Moreover, equatorial SXL prevents damage to the optic nerve; hence, the equatorial region of the sclera is the preferred location for SXL [ 4 ]. Our research group conducted a series of studies on equatorial SXL, Yu Li et al [ 12 ] irradiated one quadrant in their study on the safety and long-term scleral biomechanical stability of rhesus eyes after scleral cross-linking with blue light irradiation; Yu Li et al [ 13 ] irradiated one or two quadrants with blue light for riboflavin scleral cross-linking in an ocular safety evaluation. Anatomically, the vortex veins pass through the equatorial sclera.…”

Section: Discussionmentioning

confidence: 99%

Changes in intraocular pressure and ocular pulse amplitude of rhesus macaques after blue light scleral cross-linking

Liu

Wang

et al. 2022

BMC Ophthalmol

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Background Scleral cross-linking can enhance the biomechanical strength of the sclera and is expected to be a new operative method for the prevention of myopia. However, studies investigating the changes in intraocular pressure (IOP) and ocular pulse amplitude (OPA) after blue light-riboflavin induced scleral collagen cross-linking (SXL) in rhesus monkeys are limited. This study aimed to investigate the changes in IOP and OPA in three-year-old rhesus macaques 1 week, 1 month, and 3 months after blue light-riboflavin SXL. Methods Seven three-year-old rhesus macaques (14 eyes) were randomly divided into two groups, with 4 monkeys in group A (8 eyes) and 3 monkeys in group B (6 eyes). The right eye of each rhesus macaque was used as the experimental eye, whereas the left eye was used as the control. In group A, one quadrant of each right eye was irradiated. In group B, two quadrants of each right eye and one quadrant of each left eye were irradiated. The IOP and OPA of both eyes were measured in all seven rhesus macaques before SXL and 1 week, 1 month, and 3 months postoperatively, and differences in the IOP and OPA between the experimental and control eyes were evaluated via the paired t test. Results In groups A and B, there were no significant differences between the experimental and control eyes in the IOP or OPA before SXL or 1 week, 1 month, or 3 months postoperatively (P > 0.05). Conclusions The IOP and OPA are not significantly affected in 1 vs 0 or in 1 vs 2 quadrants of blue light SXL.

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“…Однако в настоящее время ведутся активные разработки в области коллагенового кросслинкинга склеры, и данный подход уже экспериментально реализован двумя основными способами. Первый способ использует эффект фотополимеризации -ультрафиолетовое воздействие на склеру in vivo в сочетании с ее обработкой раствором рибофлавина или использование более длинноволнового излучения с другим фотосенсибилизатором (фотохимический кросслинкинг) [89][90][91][92][93][94]. Показано, что в результате такого воздействия как в ближайшем, так и в отдаленном периоде наблюдения значительно увеличивается прочность и модуль упругости склеральной ткани за счет повышения уровня ее поперечной связанности, и при соблюдении адекватного режима процедуры отсутствует повреждающий эффект на структуры глаза, а у экспериментальных животных с индуцированной миопией отмечается существенное замедление роста ПЗО глаза [90,91,95,96].…”

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Current assessment results of the efficacy and safety of scleroplasty in progressive myopia

Iomdina

Тарутта

Маркосян

et al. 2021

Rossijskij oftalʹmologičeskij žurnal

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The purpose of the review is to analyze the data of recent studies (performed in the last two decades) of the efficacy and safety of sclera reinforcement surgeries for progressive myopia in children and adults. Short-term and long-term observation results are presented, indicating the impact of the initial degree of myopia, the patient's age, surgical technique and the choice of plastic material on the outcome of the intervention and the further course of the myopic process. The advantages of a biologically active synthetic graft are described, which makes it possible to deposit drugs that stimulate scleral crosslinking and have a biomechanical, trophic and hemodynamic effect. Crosslinking of scleral collagen is a promising approach to the treatment of myopia.

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Ocular safety evaluation of blue light scleral cross-linking in vivo in rhesus macaques

Cited by 15 publications

References 29 publications

Clinical Feasibility and Safety of Scleral Collagen Cross-Linking by Riboflavin and Ultraviolet A in Pathological Myopia Blindness: A Pilot Study

Clinical Feasibility and Safety of Scleral Collagen Cross-Linking by Riboflavin and Ultraviolet A in Pathological Myopia Blindness: A Pilot Study

Changes in intraocular pressure and ocular pulse amplitude of rhesus macaques after blue light scleral cross-linking

Current assessment results of the efficacy and safety of scleroplasty in progressive myopia

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