Ocular Surface Changes Induced by Contact Lens Wear

Pisella, Pierre‐Jean; Malet, Florence; Lejeune, Sophie; Brignole, F.; Debbasch, C.; Bara, Jacques; Rat, Patrice; Colin, Joseph; Baudouin, Christophe

doi:10.1097/00003226-200111000-00009

Cited by 88 publications

(46 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This intolerance is generally associated with dry eye symptom resulting from chronic degenerative and mildly inflammatory changes of the conjunctiva and the corneal surface. 16 Apoptosis induced by multipurpose solutions could decrease the defence systems of the ocular surface, increasing the risk of infection.…”

Section: Discussionmentioning

confidence: 99%

Severe ocular infections with contact lens: role of multipurpose solutions

Dutot

Paillet²,

Chaumeil³

et al. 2008

Eye

View full text Add to dashboard Cite

Purpose: To determine whether multipurpose solutions, widely used for contact lens disinfections, could be at the origin of ocular pathologies (contact lens intolerance and ocular infections). Methods: An observational cohort study (questionnaire analysis) was carried out to estimate the number of contact lens wearers, type of infection, and type of lens care regimen used by patients. Besides, multipurpose solutions cytotoxicity (necrosis and apoptosis) was evaluated on a conjunctival cell line using cytofluorometry. Results: In the general population, 59% of contact lens wearers use multipurpose solutions whereas 35% use oxidative products. Of the questioned contact lens wearers with ocular infections, 80% used multipurpose solutions. Multipurpose solutions are therefore not efficient enough against microorganisms, and cannot be considered as disinfectant solutions but only as preservatives. However, preservatives are known to be toxic to ocular surface, so apoptosis induced by multipurpose solutions could lead to ocular surface diseases. Our cytofluorometry study allowed us to demonstrate that contact lens multipurpose solutions containing preservatives are cytotoxic through caspase 3 induction, chromatin condensation and P2X7 cell-death receptor activation, in contrast with unpreserved sterile saline solutions that were found inert. Conclusions: Multipurpose solutions seem to be preservative but not disinfecting solutions. They are not adapted to the final rinse of contact lenses because of apoptosis induction. It could explain part of lens intolerance.

show abstract

Section: Discussionmentioning

confidence: 99%

Severe ocular infections with contact lens: role of multipurpose solutions

Dutot

Paillet²,

Chaumeil³

et al. 2008

Eye

View full text Add to dashboard Cite

show abstract

“…10 KCS and ocular rosacea were associated with overexpression of inflammatory markers such as HLA-DR and ICAM-1 and a significant decrease in the number of goblet cells. 29 Thus, in rosacea, inflammation of the ocular surface was clearly demonstrated with an increase of inflammatory mediators as interleukin (IL)-1a 30 or gelatinase B activity in tears of patients. 31 Hingorani et al 32 found a greater expression of HLA-DR in conjunctival epithelial cells in the different chronic ocular allergic disorders such as vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC).…”

Section: Discussionmentioning

confidence: 99%

“…The fact that in vitro conjunctival epithelium expresses HLA-DR, ICAM-1, CD40, and E-cadherin could suggest its role in initiation and regulation of ocular surface responses as well as its antigen-presenting properties. 33 Increased expression of HLA-DR and ICAM-1 has been reported in contact lens wearers compared to Flow cytometric analysis of HLA-DR antigen M Mrugacz et al normal eyes, 29 suggesting the possibility that contact lens use could cause inflammation of the conjunctiva. Our findings of a large number of HLA-DR þ conjunctival cells in CF patients confirm the presence of an inflammatory background and the immune nature of this disease.…”

Section: Discussionmentioning

confidence: 99%

Flow cytometric analysis of HLA-DR antigen in conjunctival epithelial cells of patients with cystic fibrosis

Mrugacz

Zak

Bakunowicz-Łazarczyk

et al. 2006

Eye

View full text Add to dashboard Cite

Purpose Cystic fibrosis (CF) is an autosomal-recessive genetic disorder. The disease affects all secretory epithelia including the eye and belongs to the group of ocular surface epithelial diseases, termed keratoconjunctivitis sicca that develop in dry eye. In the pathogenesis of dry eye, inflammation plays a crucial role. The aim of this study was to investigate the expression of HLA-DR on conjunctival epithelial cells from patients with CF. Materials and methods Twenty-five patients with CF and 25 normal subjects underwent ocular examination. Tear film break-up time (TBUT), Schirmer test, lissamine green staining, and conjunctival impression cytology were carried out. Cells were processed for flow cytometry, by using monoclonal antibodies to HLA-DR. Results The Schirmer test and TBUT scores were significantly lower in CF patients compared with controls. A significant increase of HLA-DR expression on epithelial cells was found in patients with CF compared with normal eyes. The Schirmer and TBUT test were positively correlated with HLA-DR expression for the percentage of cells. Conclusion These results suggest that conjunctival epithelial cells play an important proinflammatory role in ocular changes in CF patients. Our findings confirm the presence of an inflammatory background and the immune nature of this disease. HLA-DR measurement might be a useful method for monitoring of inflammatory processes in the conjunctiva and could be helpful in the use of antiinflammatory drugs in the treatment of ocular findings in CF patients.

show abstract

“…on numbers of polymorphonuclear leukocytes [29], tear cytokine profile [29] and increased expression of the inflammatory markers HLA -DR and ICAM-1 on ocular surface epithelia [30]. HLA-DR is a MHC class II antigen whose expression by conjunctival epithelial cells has been shown to correlate with the severity of dry eye, as characterised by vital staining and Schirmer test [31,32,33].…”

Section: Sub-clinical Inflammation Has Been Demonstrated In Contact Lmentioning

confidence: 99%

Oral omega-6 essential fatty acid treatment in contact lens associated dry eye

Kokke

Morris

Lawrenson

2008

Contact Lens and Anterior Eye

View full text Add to dashboard Cite

This is the unspecified version of the paper.This version of the publication may differ from the final published version. and also a significant improvement in overall lens comfort at 6 months (p<0.01). Permanent repository linkTear meniscus height was increased in the EPO group at 6 months relative to baseline (p<0.01), although all other objective signs were unchanged. Conclusion:This study provides evidence for a beneficial effect of particular orally administered omega-6 fatty acids in alleviating dry eye symptoms and improving overall lens comfort in patients suffering from contact lens associated dry eye.

show abstract

Ocular Surface Changes Induced by Contact Lens Wear

Cited by 88 publications

References 16 publications

Severe ocular infections with contact lens: role of multipurpose solutions

Severe ocular infections with contact lens: role of multipurpose solutions

Flow cytometric analysis of HLA-DR antigen in conjunctival epithelial cells of patients with cystic fibrosis

Oral omega-6 essential fatty acid treatment in contact lens associated dry eye

Contact Info

Product

Resources

About