Ocular Surface Disease of Rabbits

Bedard, Kathleen M.

doi:10.1016/j.cvex.2018.08.003

Cited by 10 publications

(6 citation statements)

References 30 publications

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“…Step-by-step protocol to exact tear fluid from Schirmer strips for analytical purposes, using a combination of centrifugation and solvent wash. Spontaneous ocular surface disorders are common in dogs and represent one of the major causes for referral visits to veterinary practitioners. 280 In contrast, naturally acquired ocular surface pathology is much less common in rabbits 281,282 and is rare in mice and rats. [283][284][285]…”

Section: F I G U R Ementioning

confidence: 99%

An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

Sebbag

Mochel

2020

Medicinal Research Reviews

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Preclinical animal studies provide valuable opportunities to better understand human diseases and contribute to major advances in medicine. This review provides a comprehensive overview of ocular parameters in humans and selected animals, with a focus on the ocular surface, detailing species differences in ocular surface anatomy, physiology, tear film dynamics and tear film composition. We describe major pitfalls that tremendously limit the translational potential of traditional laboratory animals (i.e., rabbits, mice, and rats) in ophthalmic research, and highlight the benefits of integrating companion dogs with clinical analogues to human diseases into preclinical pharmacology studies. This One Health approach can help accelerate and improve the framework in which ophthalmic research is translated to the human clinic. Studies can be conducted in canine subjects with naturally occurring or noninvasively induced ocular surface disorders (e.g., dry eye disease, conjunctivitis), reviewed herein, and tear fluid can be easily retrieved from canine eyes for various bioanalytical purposes. In this review, we discuss common tear collection methods, including capillary tubes and Schirmer tear strips, and provide guidelines for tear sampling and extraction to improve the reliability of analyte quantification (drugs, proteins, others).

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Section: F I G U R Ementioning

confidence: 99%

An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

Sebbag

Mochel

2020

Medicinal Research Reviews

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“…The rabbit model of PCG should avoid the interference of conjunctivitis, which is a common disease in rabbits caused by infectious and/or noninfectious diseases during the experiment [ 124 ]. And the intermittent elevation of IOP may lead to unstable experimental results [ 114 ].…”

Section: Animal Models Related To Pcgmentioning

confidence: 99%

Animal Model Contributions to Primary Congenital Glaucoma

Xia

Zhang

Zhuang

et al. 2022

Journal of Ophthalmology

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Primary congenital glaucoma (PCG) is an ocular disease characterized by congenital anterior segmental maldevelopment with progressive optic nerve degeneration. Certain genes, such as cytochrome P450 family 1 subfamily B member 1 and latent TGF-β-binding protein 2, are involved in the pathogenesis of PCG, but the exact pathogenic mechanism has not yet been fully elucidated. There is an urgent need to determine the etiology and pathophysiology of PCG and develop new therapeutic methods to stop disease progression. Animal models can simulate PCG and are essential to study the pathogenesis and treatment of PCG. Various animal species have been used in the study of PCG, including rabbits, rats, mice, cats, zebrafish, and quails. These models are formed spontaneously or by combining with genetic engineering technology. The focus of the present study is to review the characteristics and potential applications of animal models in PCG and provide new approaches to understand the mechanism and develop new treatment strategies for patients with PCG.

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“…Spontaneous ocular surface diseases in dogs with translational applications to humans Spontaneous ocular surface disorders are common in dogs and represent one of the major causes for referral visits to veterinary practitionners. 231 In contrast, naturally-acquired ocular surface pathology is much less common in rabbits 232,233 and is rare in mice and rats. 234-236…”

Section: Spontaneous and Experimental Models Of Ocular Surface Disorders In Dogsmentioning

confidence: 99%

An Eye on the Dog as the Scientist’s Best Friend for Translational Research in Ophthalmology: Focus on the Ocular Surface

Sebbag

Mochel

2020

Preprint

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Preclinical animal studies provide valuable opportunities to better understand human diseases and contribute to major advances in medicine. This review provides a comprehensive overview of ocular parameters in humans and selected animals, with a focus on the ocular surface, detailing species differences in ocular surface anatomy, physiology, tear film dynamics and tear film composition. We describe major pitfalls that tremendously limit the translational potential of traditional laboratory animals (ie., rabbits, mice and rats) in ophthalmic research, and highlight the benefits of integrating companion dogs with clinical analogues to human diseases into preclinical pharmacology studies. This One Health approach can help accelerate and improve the framework in which ophthalmic research is translated to the human clinic. Studies can be conducted in canine subjects with naturally occurring or non-invasively induced ocular surface disorders (eg., dry eye disease, conjunctivitis), reviewed herein, and tear fluid can be easily retrieved from canine eyes for various bioanalytical purposes. In this review, we discuss common tear collection methods, including capillary tubes and Schirmer tear strips, and provide guidelines for tear sampling and extraction to improve the reliability of analyte quantification (drugs, proteins, others).

show abstract

Ocular Surface Disease of Rabbits

Cited by 10 publications

References 30 publications

An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

Animal Model Contributions to Primary Congenital Glaucoma

An Eye on the Dog as the Scientist’s Best Friend for Translational Research in Ophthalmology: Focus on the Ocular Surface

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Ocular Surface Disease of Rabbits

Cited by 10 publications

References 30 publications

An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

Animal Model Contributions to Primary Congenital Glaucoma

An Eye on the Dog as the Scientist&rsquo;s Best Friend for Translational Research in Ophthalmology: Focus on the Ocular Surface

Contact Info

Product

Resources

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An Eye on the Dog as the Scientist’s Best Friend for Translational Research in Ophthalmology: Focus on the Ocular Surface