Odds of moderate or severe gastric ulceration in racehorses receiving antiulcer medications

Orsini, James A.; Haddock, Marie; Stine, Lynne; Sullivan, Eileen K.; Rabuffo, Tara S.; Smith, Gary K.

doi:10.2460/javma.2003.223.336

Cited by 27 publications

(25 citation statements)

References 14 publications

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“…Although these treatment methods have shown some effectiveness, they have low bioavailability, require large doses, and must be administered several times a day (Murray and Eichorn, 1996). So, their overall effectiveness has been lower than omeprazole (Orsini et al, 2003;Lester et al, 2005).…”

Section: Current Treatmentmentioning

confidence: 99%

“…Most investigators or research groups have developed their own scoring system, usually tailored to meet the needs of their specific EGUS research and clinical interests (Furr and Murray 1989;Murray et al, 1989;MacAllister et al, 1997;Vatistas et al, 1999a,b;Merritt, 2003;Orsini et al, 2003;Nieto et al, 2004). Without a standard scoring system, evaluation of gastric ulcers both in research and clinical settings is limited.…”

Section: Ulcer Diagnosis Scoring and Evaluationmentioning

confidence: 99%

“…Since omeprazole inhibits acid production at the proton pump, it suppresses acid secretion regardless of stimulant. Therefore, it has been proven to be an extremely effective pharmaceutical treatment for both ulcer healing and prevention (Murray et al, 1997;Merritt et al, 2003;Orsini et al, 2003;McClure et al, 2005a,c;White et al, 2007).…”

Section: Current Treatmentmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Trace Mineral Supplementation on Gastric Ulcers in Exercising Yearling Horses †

Hayes

Sigler

Cohen

et al. 2009

Journal of Equine Veterinary Science

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Equine gastric ulcer syndrome (EGUS) has been reported to occur in 40% to over 90% of horses across multiple equestrian disciplines. The objective of this study was to evaluate the effect of trace mineral supplementation on gastric ulcers in exercising yearling horses. Twenty-one Quarter Horse yearlings, 15 to 18 mo of age, were randomly assigned to 1 of 3 treatment groups. The control group received no supplemental trace minerals, the inorganic group received supplemental sulfated trace minerals, and the organic treatment received supplemental amino acid complexed trace minerals. The trial consisted of 3 consecutive 28-d periods, separated by 5 d of diet acclimation. The basal ration included a 14% CP textured concentrate, with coastal Bermudagrass hay fed in Periods 1 and 3 and alfalfa consumed in Period 2. In Periods 1 and 2, horses were exercised on a mechanical horse-exerciser, but were lunged or underwent training in an undergraduate course in Period 3. At the end of each period, horses were transported for 6 h, 5 d before being endoscopically examined to assign ulcer scores. Data were analyzed as repeated measures using the mixed procedure of iv SAS, with the model including fixed effects of treatment, period, and their interaction (SAS 9.2). All P-values < 0.05 were considered significantly different.

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Section: Current Treatmentmentioning

confidence: 99%

Section: Ulcer Diagnosis Scoring and Evaluationmentioning

confidence: 99%

Section: Current Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Trace Mineral Supplementation on Gastric Ulcers in Exercising Yearling Horses †

Hayes

Sigler

Cohen

et al. 2009

Journal of Equine Veterinary Science

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“…Recently, omeprazole has been recognized as the most effective drug for the treatment of the equine gastric ulcer [8,13] and is the only approved product to heal stomach ulcers. Omeprazole controls the gastric acid secretion by inhibiting the proton pump of the gastric parietal cells [6,13,15].…”

mentioning

confidence: 99%

“…Omeprazole controls the gastric acid secretion by inhibiting the proton pump of the gastric parietal cells [6,13,15]. Effectiveness of omeprazole is known to decrease with the effect of gastric acid.…”

mentioning

confidence: 99%

Efficacy of Omeprazole Paste in the Prevention of Gastric Ulcers in 2 Years Old Thoroughbreds

Endo

Tsuchiya

Sato

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Prevalence of equine gastric ulcer syndrome in 85 young Thoroughbreds was investigated. The presence of gastric ulcers was confirmed in 27.1% (23/85) of the horses by endoscopic examination. Sixty-two horses without gastric ulcers were allocated randomly to either the treated group (31 horses) or sham-dosed control group (31 horses) in order to investigate the efficacy of omeprazole oral paste in the prevention of gastric ulcers. At the second endoscopic examination conducted after 28 days of administration, only 1 horse in the treated group developed gastric ulcers, while 12 horses developed gastric ulcers in the control group. Based on these data, the efficacy of omeprazole in prevention of equine gastric ulcers in young Thoroughbreds during the training period was confirmed.

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Clinical application of gastrointestinal therapeutics

Sanchez

2014

Equine Pharmacology

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Odds of moderate or severe gastric ulceration in racehorses receiving antiulcer medications

Abstract: Results suggest that the proprietary formulation of omeprazole was associated with a significantly lower risk of moderate or severe gastric ulceration, compared with no treatment, in racehorses in active race training, whereas other antiulcer medications were not.

Cited by 27 publications

References 14 publications

Effect of Trace Mineral Supplementation on Gastric Ulcers in Exercising Yearling Horses †

Effect of Trace Mineral Supplementation on Gastric Ulcers in Exercising Yearling Horses †

Efficacy of Omeprazole Paste in the Prevention of Gastric Ulcers in 2 Years Old Thoroughbreds

Clinical application of gastrointestinal therapeutics

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