The ecological and economic context determine the management goals of a modern enterprise, which are in line with the growing concern about the well-being of society caused by the effects of enterprises’ activities that are particularly harmful to the environment. This increases the need to search for new tools that will have the capacity to generate information supporting the decision-making process in the area of enterprise management in terms of ecological, economic, and social goals. For these reasons, synthetic measures of development were constructed on the basis of the set of diagnostic variables describing various aspects of sustainable development in the case. Based on the environmental synthetic indicators, it has been possible to point out the Polish voivodeships, in which enterprises that are particularly harmful to the environment were able to reduce the emissions of dust and gaseous pollutants in the 2005–2019 period. These changes were often accompanied by an increase in the production of energy from renewable sources and increasing the supply of plants with devices to contain gaseous and dust pollutants. Moreover, the comparison of positioning the voivodeships in the rankings according to social, economic, and environmental synthetic measures shows that the reduction of the negative impact of energy-intensive enterprises on the environment has been associated with higher the position of the voivodeship in the ranking connected with the health of its inhabitants. It has been also seen that the largest pool of funds was allocated to the voivodeships that need them the most, as these voivodeships were low in the ranking with respect to the degree of the reduction of dust and gaseous emissions by enterprises that are particularly harmful to the environment. The results for regression analysis indicated at the existence of the inter-temporal relationships between the well-being of society and the environmental–economic effects of enterprises’ activities. It was noticed that increasing the possibilities of financing investments in low-emission development of the region, including the modernization of enterprises in terms of decreasing dust and gaseous pollutant emissions and reducing their energy consumption, has a significant impact on the improvement of well-being of society with a one-year lag. In contrast to other studies that mainly refer to the environmental and economic effects of managing enterprises that are particularly harmful to the environment, this paper focuses on the social aspect of the change in the health of the population connected with the emissions of pollutants. A novel approach based on the set of three multi-criteria synthetic measures is proposed to assess the environmental, economic, and social activities of enterprises in individual voivodeships in Poland in the long 2005–2019 period.