Odontoclastic resorption of the superficial nonmineralized layer of predentine in the shedding of human deciduous teeth

Sahara, Noriyuki; Okafuji, Norimasa; Toyoki, A.; Ashizawa, Yuji; Deguchi, Toshio; Suzuki, Kazuo

doi:10.1007/s004410050127

Cited by 12 publications

(16 citation statements)

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“…These cells have morphological and functional characteristics similar to those of bone-resorbing osteoclasts (Sahara et al, 1994(Sahara et al, , 1998. Osteoclast and odontoclast precursors originate from hemopoietic cells in the bone marrow.…”

Section: (Vi) Cellular and Molecular Mechanisms Of Odontoclast/osteocmentioning

confidence: 97%

Genetic Factors in External Apical Root Resorption and Orthodontic Treatment

Hartsfield

Everett

Al-Qawasmi

2004

Critical Reviews in Oral Biology & Medicine

159

109

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External apical root resorption (EARR) is a common sequela of orthodontic treatment, although it may also occur in the absence of orthodontic treatment. The degree and severity of EARR associated with orthodontic treatment are multifactorial, involving host and environmental factors. Genetic factors account for at least 50% of the variation in EARR. Variation in the Interleukin 1 beta gene in orthodontically treated individuals accounts for 15% of the variation in EARR. Historical and contemporary evidence implicates injury to the periodontal ligament and supporting structures at the site of root compression following the application of orthodontic force as the earliest event leading to EARR. Decreased IL-1␤ production in the case of IL-1B (+3953) allele 1 may result in relatively less catabolic bone modeling (resorption) at the cortical bone interface with the PDL, which may result in prolonged stress concentrated in the root of the tooth, triggering a cascade of fatigue-related events leading to root resorption. One mechanism of action for EARR may be mediated through impairment of alveolar resorption, resulting in prolonged stress and strain of the adjacent tooth root due to dynamic functional loads. Future estimation of susceptibility to EARR will likely require the analysis of a suite of genes, root morphology, skeleto-dental values, and the treatment method to be used-or essentially the amount of tooth movement planned for treatment.

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Section: (Vi) Cellular and Molecular Mechanisms Of Odontoclast/osteocmentioning

confidence: 97%

Genetic Factors in External Apical Root Resorption and Orthodontic Treatment

Hartsfield

Everett

Al-Qawasmi

2004

Critical Reviews in Oral Biology & Medicine

159

109

View full text Add to dashboard Cite

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“…As células envolvidas nas reabsorções dentárias e ósseas são os clastos, mononucleares 13 e multinucleares, os osteoblastos e os macrófagos, constituindo a unidade osteorremodeladora ou BMU 13,20,37,51,69,73,74,76 . Mediadores bioquímicos sintetizados e liberados durante a reabsorção medeiam os eventos celulares e a manutenção deste processo 69 .…”

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“…avaliação do número médio de núcleos em clastos multinucleados 14 ; citodiferenciação e degeneração destas células 74 ; a caracterização dos clastos reabsorvendo dentina 66,69,70 e esmalte 5,71 e a marcação de enzimas liberadas pelos clastos durante a reabsorção dentária 42,77 . Nestes estudos não foram identificadas diferenças morfológicas e histoquímicas entre odontoclastos e osteoclastos 37, 51,69,70,73 .…”

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“…Nestes estudos não foram identificadas diferenças morfológicas e histoquímicas entre odontoclastos e osteoclastos 37, 51,69,70,73 .…”

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“…A marcação da atividade da fosfatase ácida tartarato-resistente (TRAP) possibilita localizar especificamente clastos e pré-clastos mononucleares 63,69,70,71 . Esta glicoproteína catiônica sintetizada pelos clastos, dentro das áreas de reabsorção e próximas as bordas ativas ou em escova, atua cataliticamente na remoção de fosfato antes da solubilização da hidroxiapatita 63 .…”

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