Odontogenic keratocysts: Clinicopathologic study of 87 cases

E, Kakarantza-Angelopoulou; Nicolatou, O

doi:10.1016/s0278-2391(10)80472-0

Cited by 80 publications

(58 citation statements)

References 29 publications

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“…Our investigation gives new results by showing a different concentration of TNF-α in cystic fluid between two cyst types in the maxillofacial skeleton. These data reflect the ethiopathology of radicular cysts as inflammatory and shaw that there are results in infection and necrosis of the dental pulps in carious teeth and cystic tissue (15). The growth of radicular cysts is accompanied by local bone destruction, tissue osteolysis and accumulation of different cells in the cystic epithelium.…”

Section: Discussionsupporting

confidence: 64%

The Inflammatory Radicular Cysts Have Higher Concentration of TNF-α in Comparison to Odontogenic Keratocysts (Odontogenic Tumour)

Jurišić

Colic

Jurišić

2007

Acta Med. (Hradec Kralove, Czech Repub.)

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TNF-α is a pleiotropic cytokine that is considered as a primary modifier of inflammatory and immune reaction in response to various inflammatory diseases and tumour. We investigated levels of TNF-α in 43 radicular cysts and 15 odontogenic keratocysts, obtained from patients undergoing surgery, under local anaesthesia, and after aspiration of cystic fluid from non-ruptured cysts. TNF-α is elevated in both cysts’ fluid, but higher values were found in radicular cysts in comparison to keratocysts. The significantly higher concentration of TNF-α was associated with smaller radicular cysts, higher protein concentration, higher presence of inflammatory cells in peri cystic tissues, and the degree of vascularisation and cysts wall thickness (Mann-Whitney U-test, p<0.05). No correlation was found based on these parameters in odontogenic keratocyst, but all cysts have detectable concentrations of TNF-α. We here for the first time present that a difference in the concentration of TNF-α exists between these two cystic types.

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Section: Discussionsupporting

confidence: 64%

The Inflammatory Radicular Cysts Have Higher Concentration of TNF-α in Comparison to Odontogenic Keratocysts (Odontogenic Tumour)

Jurišić

Colic

Jurišić

2007

Acta Med. (Hradec Kralove, Czech Repub.)

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“…The lesion occurs over a wide age range with a peak in the second and third decades and demonstrates a predilection for white males (13,14). On the other hand, some authours found a major peak of frequency of KCOTs in the fifth and sixth decades of life (15). In the presented study, KCOTs had a peak of occurance in the third decade of life, followed by the fifth decade.…”

Section: Discussionsupporting

confidence: 38%

Keratokistik odontojenik tümör: 64 vakalık retrospektif çalışma

Akay¹,

Tetik²,

Zeytinoğlu³

2015

Ege Tıp Dergisi

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Aim: The purpose of this retrospective study was to evaluate the clinicopathological features of 64 patients with keratocystic odontogenic tumor (KCOT). Materials and Methods:The patients ranged in age at the time of diagnosis from 8 to 74 years (mean: 38.20 ± 16.71). Postoperative follow-up period was 3-8 years (mean time 4.76 ± 1.10). This research was carried out on panoramic radiographs and histopathological samples. Data such as gender, age, treatment methods, location of the tumor, presence of impacted teeth and its histological features were subjected to descriptive statistical analyses with the statistical software program. Results:Of the 64 analyzed cases of KCOT, 68.8% of them were men and 31.2% were females (male-to-female ratio was 2.2:1). It was observed that KCOT peaked in the third and fifth decade of life (23.4%-20.3%). The incidence of KCOT was higher in the mandible than in the maxilla (76.6%-23.4%). There was recurrence in nine out of 64 subjects (14.1%) in the follow-up period. The recurrence was more often found in posterior mandible. It is noteworthy that in 9 recurrent subjects, 7 lesions were parakeratotic and 4 lesions were associated with daughter cysts. Conclusion:Although there are several studies about KCOT in the literature, the choice of treatment modalities remains controversial. In recurrent subjects, more aggressive therapy approaches should be considered. Periodic controls and aggressive treatment approaches may be effective in the prevention of recurrences. (%23.4-%20.3). KOT insidansı mandibulada maksillaya oranla daha yüksekti (% 76.6-% 23.4 Keywords

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“…OKCs occur predominantly in Caucasians (5,6) and are more common in males than in females (5,6,8). There is a wide age range of patients, with a peak frequency in the second and third decades (5,6,9).…”

Section: Review Of the Literaturementioning

confidence: 99%

“…The tendency for recurrence has been attributed to the OKCs unique histological, chemical and physical features (8,20,(22)(23)(24). Voorsmit, Stoelinga and van Haelst (25) demonstrated the presence of microcysts in the mucosa overlying recurrent lesions; they recommend excision of overlying mucosa at cystectomy.…”

Section: Review Of the Literaturementioning

confidence: 99%