Odour of limonene affects feeding behaviour in the blowfly, Phormia regina

Nakamura, Atsushi; Suzuki, Tomoyuki; Taniguchi, Daiki; Matsuda, Atsushi; Tobeta, Manabu; Nakamura, Tadashi

doi:10.1016/j.neulet.2008.09.021

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…Our previous works have shown that both tacrine and bis (7)-tacrine inhibited the locomotor activity in normal mice and improved the impairment of open-field and passive avoidance response memory in mice treated with scopolamine [13][14][15]. Cycloheximide (CYH) is a protein synthesis inhibitor widely used for investigating the biochemical mechanism(s) underlying the consolidation of long-term memory [16][17][18][19]. In this study, we examined the effect of CYH per se or CYH in combination with tacrine or bis (7) tacrine on cognitive behaviour using open-field test and stepthrough task in the mice.…”

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confidence: 99%

Tacrine and Bis(7)-Tacrine Attenuate Cycloheximide-Induced Amnesia in Mice, with Attention to Acute Toxicity

Pan

Zhang

Guo

et al. 2011

Basic &Amp; Clinical Pharmacology &Amp; Toxicology

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Effects of tacrine and bis(7)-tacrine (0.25-20 lmol ⁄ kg, s.c.) on cognitive behaviour in cycloheximide (CYH)-treated mice were investigated. Cognitive behaviour was assessed by open-field test and step-through task with a 24-hr retention interval. Drugs or vehicle was given 30 min. prior to the first session. Although CYH treatment (110 mg ⁄ kg, i.p.) alone did not affect the locomotor activity of mice, CYH treatment in combination with tacrine (20 lmol ⁄ kg) decreased the locomotor activity by 37% in the acquisition session, when compared with mice treated with CYH alone. Bis-(7) tacrine cotreatment did not produce any detectable effect on locomotor activity. During the retention trial, tacrine (5 lmol ⁄ kg) or bis(7)-tacrine (1 lmol ⁄ kg) enhanced the retention latency (by 3.8-or 1.4-fold, respectively) in CYH-treated mice. In both training and retention trials, CYH treatment increased the number of footshocks (by 50% and 11.3-fold, respectively). However, during the retention (but not training) trial, tacrine (5 lmol ⁄ kg) or bis(7)-tacrine (1 lmol ⁄ kg) decreased the footshocks (by 8.6-fold or 39%, respectively) in CYH-treated mice. Combined treatment with CYH and bis(7)-tacrine (but not tacrine) resulted in an increased mortality rate in mice. The results indicated that tacrine and bis (7)-tacrine improved the amnesia caused by CYH treatment. However, the combined treatment with bis(7)-tacrine and CYH administration caused acute toxicity.Acetylcholine (ACh) is widely distributed in the central and peripheral nervous system. ACh released from cholinergic nerve terminals activates receptors at both pre-synaptic and post-synaptic sites. It is then hydrolysed by acetylcholinesterase (AChE) into choline and acetyl coenzyme A. Cholinergic nerve in the brain may play an important role in many cognitive functions, such as cortical modulation of sensory information processing, attention, memory and learning [1][2][3]. Therapeutic strategies adopting cholinergic precursor loading and AChE inhibitors, which can increase ACh concentration in vivo, were used for treating cognitive impairment occurring in Alzheimer's disease (AD) and geriatric memory dysfunction [4][5][6].The cognitive enhancement and AChE inhibition afforded by tacrine, a reversible AChE inhibitor, has been widely studied. The administration of tacrine is often accompanied by abnormal behaviour and a decline in physical strength in patients [7,8]. Bis(7)-tacrine is a novel anti-AD agent that can reversibly inhibit AChE 150-fold more potently than tacrine in rat brains [9,10]. The cognitive enhancement of bis(7)-tacrine was observed in rats treated with scopolamine, a muscarinic cholinergic receptor antagonist that causes memory loss, and AF64A, a cholinergic neuron-specific neurotoxin [11,12]. Our previous works have shown that both tacrine and bis(7)-tacrine inhibited the locomotor activity in normal mice and improved the impairment of open-field and passive avoidance response memory in mice treated with scopolamine [13][14][15]. Cycloheximi...

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mentioning

confidence: 99%

Tacrine and Bis(7)-Tacrine Attenuate Cycloheximide-Induced Amnesia in Mice, with Attention to Acute Toxicity

Pan

Zhang

Guo

et al. 2011

Basic &Amp; Clinical Pharmacology &Amp; Toxicology

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“…Dietary supplementation with thyme essential oil (400 ppm) decreased food intake, with no significant change in body weight gain in Japanese quails [59]. Flies simultaneously exposed to D-limonene and sucrose for 10 min showed significantly decreased appetite compared with flies exposed to sucrose alone [42] (Tables 5 and 6).…”

Section: Essential Oils and Fragrant Compounds With Appetite-reducing...mentioning

confidence: 96%

“…To elucidate the role of memory formation in appetite regulation, which requires new protein synthesis, Nakamura et al injected the protein synthesis inhibitor cycloheximide into the thorax of flies previously exposed to limonene and sucrose. They found that over 60% of test flies showed a proboscis extension reflex to sucrose, compared with only 20% of flies in the control group [42] (Table 6).…”

Section: Essential Oils and Fragrant Compounds Affect Appetite Via Co...mentioning

confidence: 99%

“…Flies that previously experienced food with an unpleasant odor (Dlimonene) maintained a significantly reduced appetite for that food for at least three days. This could be explained by the unpleasant odor-induced memory of the food that encouraged avoidance [42]. Indeed, flies that lacked the mushroom body, which is required for memory formation, did not show any reduction in sucrose appetite, while cycloheximide, a protein synthesis inhibitor, improved appetite loss in limonene-treated flies [42,141,142].…”

Section: Mechanisms Of Action In Appetite Regulationmentioning

confidence: 99%

“…A 2005 study on the blowfly Phormia regina revealed that flies exposed to sucrose simultaneously flavored with D-limonene experienced a decreased appetite for plain sucrose that lasted for at least three days. However, this decrease was not observed in flies lacking the mushroom body, a prominent structure for primary memory in the insect brain [42,78]. To elucidate the role of memory formation in appetite regulation, which requires new protein synthesis, Nakamura et al injected the protein synthesis inhibitor cycloheximide into the thorax of flies previously exposed to limonene and sucrose.…”

Section: Essential Oils and Fragrant Compounds Affect Appetite Via Co...mentioning

confidence: 99%

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Effects of Essential Oils and Fragrant Compounds on Appetite: A Systematic Review

Nguyen

Tran

Nguyen

et al. 2023

IJMS

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Appetite dysregulation is one of the factors contributing to anorexia, bulimia nervosa, obesity, and diabetes. Essential oils or fragrant compounds have been proven to regulate food intake and energy expenditure; hence, this study aimed to summarize their effects on appetite and the underlying mechanisms. The PubMed and Web of Science databases were searched until July 2022. Only two of the 41 studies were performed clinically, and the remaining 39 used animal models. Oral administration was the most common route, and a dosage range of 100–2000 mg/kg for mice or 2–32 mg/kg for rats was applied, with a duration of 12 days to 4 weeks, followed by inhalation (10−6–10−3 mg/cage or 10−9–10−2 mg/cm3 within 1 h). Approximately 11 essential oil samples and 22 fragrant compounds were found to increase appetite, while 12 essential oils and seven compounds decreased appetite. These fragrant components can exert appetite-regulating effects via leptin resistance, the activity of sympathetic/parasympathetic nerves, or the mRNA expression of neuropeptide Y (NPY)/agouti-related protein (AgRP), cocaine- and amphetamine-regulated transcript (CART)/proopiomelanocortin (POMC) in the hypothalamus. Fragrance memory and cognitive processes may also play roles in appetite regulation. The findings of this study accentuate the potential of essential oils and fragrant compounds to regulate appetite and eating disorders.

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Dual action of Catsia tora in tea plantations: repellent volatiles and augmented natural enemy population provide control of tea green leafhopper

et al. 2014

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Odour of limonene affects feeding behaviour in the blowfly, Phormia regina

Cited by 6 publications

References 8 publications

Tacrine and Bis(7)-Tacrine Attenuate Cycloheximide-Induced Amnesia in Mice, with Attention to Acute Toxicity

Tacrine and Bis(7)-Tacrine Attenuate Cycloheximide-Induced Amnesia in Mice, with Attention to Acute Toxicity

Effects of Essential Oils and Fragrant Compounds on Appetite: A Systematic Review

Dual action of Catsia tora in tea plantations: repellent volatiles and augmented natural enemy population provide control of tea green leafhopper

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