Odour quality processing by bee antennal lobe interneurones

Sun, Xinde; Fonta, Caroline; Masson, C.

doi:10.1093/chemse/18.4.355

Cited by 77 publications

(58 citation statements)

References 59 publications

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“…Figure 5B illustrates two LNs that innervated the anterolateral glomeruli either sparsely or not at all, together with a third LN that innervated all glomeruli more uniformly. These three LNs are reminiscent of types that have been described previously (as "asymmetrical" and "symmetrical multiglomerular LNs," respectively) in other insects (Matsumoto and Hildebrand, 1981;Ernst and Boeckh, 1983;Flanagan and Mercer, 1989;Christensen et al, 1993;Sun et al, 1993;Anton and Hansson, 1994).…”

Section: Single Local Neurons Arborize Widely But Nonuniformly Througsupporting

confidence: 52%

Role of GABAergic Inhibition in Shaping Odor-Evoked Spatiotemporal Patterns in theDrosophilaAntennal Lobe

Wilson¹,

Laurent²

2005

J. Neurosci.

440

534

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Drosophila olfactory receptor neurons project to the antennal lobe, the insect analog of the mammalian olfactory bulb. GABAergic synaptic inhibition is thought to play a critical role in olfactory processing in the antennal lobe and olfactory bulb. However, the properties of GABAergic neurons and the cellular effects of GABA have not been described in Drosophila, an important model organism for olfaction research. We have used whole-cell patch-clamp recording, pharmacology, immunohistochemistry, and genetic markers to investigate how GABAergic inhibition affects olfactory processing in the Drosophila antennal lobe. We show that many axonless local neurons (LNs) in the adult antennal lobe are GABAergic. GABA hyperpolarizes antennal lobe projection neurons (PNs) via two distinct conductances, blocked by a GABA A -and GABA B -type antagonist, respectively. Whereas GABA A receptors shape PN odor responses during the early phase of odor responses, GABA B receptors mediate odor-evoked inhibition on longer time scales. The patterns of odor-evoked GABA B -mediated inhibition differ across glomeruli and across odors. Finally, we show that LNs display broad but diverse morphologies and odor preferences, suggesting a cellular basis for odor-and glomerulus-dependent patterns of inhibition. Together, these results are consistent with a model in which odors elicit stimulus-specific spatial patterns of GABA release, and as a result, GABAergic inhibition increases the degree of difference between the neural representations of different odors.

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Section: Single Local Neurons Arborize Widely But Nonuniformly Througsupporting

confidence: 52%

Role of GABAergic Inhibition in Shaping Odor-Evoked Spatiotemporal Patterns in theDrosophilaAntennal Lobe

Wilson¹,

Laurent²

2005

J. Neurosci.

440

534

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“…The possibility, however, of different morphological and physiological properties of LN subpopulations have not been considered in detail. In many insect species, odor stimulation induces depolarization and the generation of action potentials (Matsumoto and Hildebrand, 1981;Christensen et al, 1993;Sun et al, 1993;Hansson et al, 1994;Han et al, 2005;Wilson and Laurent, 2005), and although the underlying ionic currents were generally not specifically determined, it was assumed that their action potentials were driven by Na ϩ . Only for locusts is there evidence that LNs do not generate Na ϩ -driven action potentials (Laurent and Davidowitz, 1994), but instead, graded TTX-resistant active potentials, which might be driven by Ca 2ϩ as suggested by Laurent (1996).…”

Section: Types Of Local Interneuronsmentioning

confidence: 99%

“…Accordingly LNs can also be excitatory, as demonstrated recently (Olsen et al, 2007;Shang et al, 2007). Although odorinduced responses of LNs have been described in many insect species (Matsumoto and Hildebrand, 1981;Christensen et al, 1993;Sun et al, 1993;Hansson et al, 1994;Laurent and Davidowitz, 1994;Wilson and Laurent, 2005), relatively little is known about the heterogeneity in the intrinsic firing properties and the ionic mechanisms underlying these properties in LNs. Except in LNs of the locust, in which it has been suggested that depolarizations are driven by Ca 2ϩ (Laurent, 1996), it was generally assumed that their action potentials (APs) were driven by Na ϩ .…”

Section: Introductionmentioning

confidence: 98%

Calcium Current Diversity in Physiologically Different Local Interneuron Types of the Antennal Lobe

Husch¹,

Paehler²,

Fusca³

et al. 2009

J. Neurosci.

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Behavioral and physiological studies show that neuronal interactions among the glomeruli in the insect antennal lobe (AL) take place during the processing of odor information. These interactions are mediated by a complex network of inhibitory and excitatory local interneurons (LNs) that restructure the olfactory representation in the AL, thereby regulating the tuning profile of projection neurons. In Periplaneta americana, we characterized two LN types with distinctive physiological properties: (1) type I LNs that generated Na ϩ -driven action potentials on odor stimulation and exhibited GABA-like immunoreactivity (GLIR) and (2) type II LNs, in which odor stimulation evoked depolarizations, but no Na ϩ -driven action potentials (APs). Type II LNs did not express voltage-dependent transient Na ϩ currents and accordingly would not trigger transmitter release by Na ϩ -driven APs. Ninety percent of type II LNs did not exhibit GLIR. The distinct intrinsic firing properties were reflected in functional parameters of their voltage-activated Ca 2ϩ currents (I Ca ). Consistent with graded synaptic release, we found a shift in the voltage for half-maximal activation of I Ca to more hyperpolarized membrane potentials in the type II LNs. These marked physiological differences between the two LN types imply consequences for their computational capacity, synaptic output kinetics, and thus their function in the olfactory circuit.

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“…Local antennal-lobe interneurons (LNs), for example, can spread information from one glomerulus to another, and projection (output) neurons (PNs) can convey information to higher brain centres from one, or more glomeruli. Consistent with these possibilities, LNs generally extend processes to many glomeruli within the AL (Fonta et al 1993;Linster et al 2005;Sun et al 1993) and PNs in the honey bee vary in the number of glomeruli they innervate (Abel et al 2001;Brandt et al 2005;Kirschner et al 2006;Müller et al 2002). Uniglomerular PNs (uPNs), which send projections into a single glomerulus could convey information specific to one pheromone component, whereas PNs projecting to multiple glomeruli (multiglomerular PNs, mPNs) might instead integrate information originating from multiple glomeruli.…”

Section: H O W a R E 9 O D A S I G N A L S Processed In The Brain?mentioning

confidence: 86%

“…ALs are the equivalent of vertebrate olfactory bulbs (Hildebrand and Shepherd 1997) and like olfactory bulbs, ALs are organised into spheroidal subunits known as 'glomeruli' (see ALs, Figure 1). Within the glomeruli, ORNs make synaptic contact with local antennal-lobe neurons (LNs) and projection (output) neurons (PNs) that may process information entering the AL before it is conveyed (by PNs) to higher centres of the brain (Fonta et al 1993;Gascuel and Masson 1991;Sun et al 1993). Activity at this level can also be influenced by modulatory neurons (for example neurons that release dopamine, octopamine or serotonin) that project into the ALs from other parts of the brain (Hammer 1993;Kirchhof et al 1999;Kreissl et al 1994;Mercer et al 1983;Rehder et al 1987;Schäfer and Rehder 1989).…”

Section: Amor11 Is the Olfactory Receptor That Detects 9odamentioning

confidence: 99%

Queen mandibular pheromone: questions that remain to be resolved

Jarriault

Mercer

2012

Apidologie

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-The discovery of 'queen substance', and the subsequent identification and synthesis of key components of queen mandibular pheromone, has been of significant importance to beekeepers and to the beekeeping industry. Fifty years on, there is greater appreciation of the importance and complexity of queen pheromones, but many mysteries remain about the mechanisms through which pheromones operate. The discovery of sex pheromone communication in moths occurred within the same time period, but in this case, intense pressure to find better means of pest management resulted in a remarkable focusing of research activity on understanding pheromone detection mechanisms and the central processing of pheromone signals in the moth. We can benefit from this work and here, studies on moths are used to highlight some of the gaps in our knowledge of pheromone communication in bees. A better understanding of pheromone communication in honey bees promises improved strategies for the successful management of these extraordinary animals.queen mandibular pheromone / Apis mellifera / olfactory system / biogenic amines / juvenile hormone / ecdysteroids

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Odour quality processing by bee antennal lobe interneurones

Cited by 77 publications

References 59 publications

Role of GABAergic Inhibition in Shaping Odor-Evoked Spatiotemporal Patterns in theDrosophilaAntennal Lobe

Role of GABAergic Inhibition in Shaping Odor-Evoked Spatiotemporal Patterns in theDrosophilaAntennal Lobe

Calcium Current Diversity in Physiologically Different Local Interneuron Types of the Antennal Lobe

Queen mandibular pheromone: questions that remain to be resolved

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