Oesophageal dilatation in Parkinson's disease

Gibberd, F. B.; Gleeson, J. A.; Gossage, A. A. R.; Wilson, Robert S.

doi:10.1136/jnnp.37.8.938

Cited by 32 publications

(16 citation statements)

References 10 publications

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“…Eadie and Tyrer [4] observed GE reflux in 30.4%of their patients with parkinsonism, more than three times as frequent as their control population. Gibberd et al [10] recorded similar abnormalities in 14% of their studied patients. We noted hiatal hernias in 14.7% but confirmed GE reflux in 57.9% of our patients.…”

Section: Discussionmentioning

confidence: 51%

“…Edwards et al [30], reviewing gastrointestinal function in PD, estimated that almost 7% of patients had esophageal dysmotility. Other investigators detail a range of esophageal abnormalities from minor peristaltic slowing to patulency and aperistalsis [5,10]. In our experience, aberrant esophageal peristalsis and motility are commonplace, regardless of disease severity.…”

Section: Discussionmentioning

confidence: 80%

“…Although Parkinson described dysphagia in his 1817 description of the illness [1], the first English citation documenting related radiologic abnormalities did not appear until 1945 when Penner and Druckerman [2] reported esophageal dysmotility. Over the next five decades, many investigators have focused on pharyngo-esophageal (PE) transport in PD, reporting slowed peristalsis, pharyngeal retention, cricopharyngeal sphincter abnormalities, and esophageal dilation [3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”

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confidence: 99%

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Pharyngo-Esophageal Dysphagia in Parkinson's Disease

1997

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The radiologic characteristics of pharyngoesophageal (PE) dysfunction in Parkinson's disease (PD) are not well established, partly because most previous studies have examined only small numbers of patients. We administered a dynamic videofluoroscopic swallowing function study to 71 patients with idiopathic PD. Using the Hoehn and Yahr disease severity scale, patients were subdivided into those with mild/moderate disease, subgroup I (n = 38), and advanced PD disease, subgroup II (n = 33). From pharyngeal ingestion to gastric emptying, bolus transport was normal in only 2 patients. The most common abnormalities occurring during pharyngeal ingestion included impaired motility, vallecular and pyriform sinus stasis, supraglottic and glottic aspiration, and deficient epiglottic positioning and range of motion. Esophageal abnormalities were multiple but most commonly included delayed transport, stasis, bolus redirection, and tertiary contractions. Typical aberrations of lower esophageal sphincter (LES) function included an open or delayed opening of the LES and gastro-esophageal reflux. A pathogenesis linking PE with the pathology of PD is proposed.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 80%

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confidence: 99%

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Pharyngo-Esophageal Dysphagia in Parkinson's Disease

1997

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“…Radiologically, diminished peristalsis and dilatation of the esophagus, megacolon, and dilatation of the small intestine have also been reported (LEWITAN et al, 1951;GIBBERD et al, 1974;LOGE-MANN et al, 1975). However, the pathological basis for those alimentary symptoms in Parkinson's disease has remained uncertain.…”

Section: Significance Of Lewy Bodies In the En-teric Nervous System Imentioning

confidence: 95%

Lewy bodies in the enteric nervous system in Parkinson's disease.

Wakabayashi

Takahashi

Takeda

et al. 1989

Arch. Histol. Cytol.

127

121

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“…Therefore in future studies of disturbances in the auto nomic regulation in Parkinson's syndrome only patients with IPD should be examined; thus, in the examinations the pathogenesis of Parkinson's syndrome should be tak en into consideration. Vegetative disturbancees in the upper gastrointestinal tract are very common [19,20]. Whether these should also be divided into separate groups according to the etiology of the Parkinson syndrome has to be investigated in a future study.…”

Section: Discussionmentioning

confidence: 99%

Colonic Transit Time in Nonidiopathic Parkinson’s Syndrome

Jost¹,

Jung²,

Schimrigk³

1994

Eur Neurol

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Constipation is well known to be a frequent symptom in idiopathic Parkinson’s disease. In this study, colonic transit time was measured in 16 patients with nonidiopathic Parkinson’s syndrome (non-IPS). These patients all had lacunar infarcts in the caudate, putamen, or globus pallidus, as a cause of the disease, as demonstrated by MRI. In comparison with the control group there was only a slightly longer transit time with, on the whole, a normal transit time (about 59 h). In only five cases was the transit time significantly decreased. Our results suggest that colonic transit is only prolonged in patients with idiopathic PD, whereas it is normal in non-IPS. This seems to be cause by a multi-degenerative process in the idiopathic disease.

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Oesophageal dilatation in Parkinson's disease

Cited by 32 publications

References 10 publications

Pharyngo-Esophageal Dysphagia in Parkinson's Disease

Pharyngo-Esophageal Dysphagia in Parkinson's Disease

Lewy bodies in the enteric nervous system in Parkinson's disease.

Colonic Transit Time in Nonidiopathic Parkinson’s Syndrome

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