Oesophageal involvement in pemphigus vulgaris

Mucocutaneous bullous amyloidosis with an unusual mixed protein composition of amyloid deposits

“…Although extension of bullous lesions to involve oral mucosa has previously been noted in two patients with bullous amyloidosis, 10 to our knowledge there has been no prior description of an oesophagopharyngeal disease. Vesicobullous oesophagitis is known to occur in several types of bullous dermatoses, including bullous pemphigoid, mucous membrane pemphigoid, various forms of pemphigus and epidermolysis bullosa, Hailey–Hailey disease, Darier disease, Stevens–Johnson syndrome and graft‐versus‐host disease 11–14 . The oesophagopharyngeal lesions in our patient were associated with dysphagia and were probably the cause of her gastrointestinal bleeding and microcytic anaemia.…”

Evaluation of pharyngo‐oesophageal involvement in pemphigus vulgaris and its correlation with disease activity

“…However, it is difficult to evaluate pharyngo‐oesophageal involvement because of the low prevalence of upper gastrointestinal endoscopy (UGE) in patients with PV. In contrast, recent studies have shown a relatively high incidence (46–87%) of oesophageal involvement in PV, emphasizing the importance of considering pharyngo‐oesophageal involvement in PV.…”

Development of oesophageal involvement in a subject with pemphigus vulgaris: a case report and review of the literature

“…3 Delayed diagnosis or misinterpretation can be avoided by performing oesophagogastroduodenoscopy in selected cases; in particular in cases presenting a history of pemphigus vulgaris and who report oesophageal symptoms that do not respond to steroids and antacid /antisecretive adjustment. 2,22,27,28 The EGDS should be performed by a skilled endoscopist to avoid any examination-related exacerbation of the oesophageal lesions due to scope-induced positive Nikolsky sign. 29 -31 In cases like the one presented here the correct diagnosis may avoid serious problems, such as oesophageal stenosis or regurgitation of oesophageal mucosa, because it allows for prompt increase in daily steroid dosages and antacid/antisecretive treatment, even in subjects with mild skin lesions.…”

“…29 -31 In cases like the one presented here the correct diagnosis may avoid serious problems, such as oesophageal stenosis or regurgitation of oesophageal mucosa, because it allows for prompt increase in daily steroid dosages and antacid/antisecretive treatment, even in subjects with mild skin lesions. 27…”