Oesophageal Squamous Dysplasia

Auld, Michael; Srinath, Havish; Jeyarajan, Eshwarshanker

doi:10.1007/s12029-018-0122-3

Cited by 3 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 With the advancement and availability of high-resolution or image-enhanced endoscopy, an increasing number of early neoplastic lesions can be detected either during health checks or through surveillance after treatment of primary cancers. 2 A multicenter cross-sectional study conducted in China, involving 44 857 screening endoscopies in a population screening, showed an incidence of 4.18% for low-grade intraepithelial neoplasia (LGIN) and 0.9% for high-grade intraepithelial neoplasia (HGIN). 3 Another community-based long-term study on the incidence of progression to invasive cancer from LGIN, with or without endoscopic surveillance, showed that patients with LGIN, regardless of surveillance, had a higher risk of esophageal squamous cell carcinoma (ESCC) than the general population.…”

Section: Precursor and Riskmentioning

confidence: 99%

Management of Multifocal Squamous Dysplasia: Role of Esophagectomy

Wong,

Law

2024

Foregut: The Journal of the American Foregut Society

View full text Add to dashboard Cite

Squamous dysplasia precedes invasive squamous cell carcinoma of the esophagus, but there is limited evidence on its surgical management. The “field change effect” further complicates matters, causing multifocal or second primary neoplasms in the esophagus and upper aerodigestive tract. While endoscopic procedures are the primary treatment, surgical resection, either alone or in combination with endoscopy, must be considered given the extent of the disease and organ involvement. This chapter summarizes multifocal squamous dysplasia scenarios and highlights the role of esophagectomy or surgical resection.

show abstract

Section: Precursor and Riskmentioning

confidence: 99%

Management of Multifocal Squamous Dysplasia: Role of Esophagectomy

Wong,

Law

2024

Foregut: The Journal of the American Foregut Society

View full text Add to dashboard Cite

show abstract

“…There are two major subtypes of esophageal cancer: Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)[ 22 ]. Esophageal squamous dysplasia (ESD) is believed to be the precancerous lesion of ESCC[ 23 - 25 ], and Barrett’s esophagus (BE) is the identifiable precancerous lesion associated with EAC[ 4 , 26 ]. Endoscopic surveillance is recommended by GI societies to enable early detection of the two precancerous lesions of esophageal cancer[ 25 , 27 ].…”

Section: In Endoscopic Detection Of Precancerous Lesions In Esophageal Mucosamentioning

confidence: 99%

“…Low-grade and high-grade intraepithelial neoplasms, collectively referred to as ESD, are deemed as precancerous lesions of ESCC. Early and accurate detection of ESD is essential but also full of challenges[ 23 - 25 ]. DL is reliably able to depict ESD in real-time upper endoscopy.…”

Section: In Endoscopic Detection Of Precancerous Lesions In Esophageal Mucosamentioning

confidence: 99%

Deep learning for diagnosis of precancerous lesions in upper gastrointestinal endoscopy: A review

Yan

Wong

Qin

2021

WJG

View full text Add to dashboard Cite

Upper gastrointestinal (GI) cancers are the leading cause of cancer-related deaths worldwide. Early identification of precancerous lesions has been shown to minimize the incidence of GI cancers and substantiate the vital role of screening endoscopy. However, unlike GI cancers, precancerous lesions in the upper GI tract can be subtle and difficult to detect. Artificial intelligence techniques, especially deep learning algorithms with convolutional neural networks, might help endoscopists identify the precancerous lesions and reduce interobserver variability. In this review, a systematic literature search was undertaken of the Web of Science, PubMed, Cochrane Library and Embase, with an emphasis on the deep learning-based diagnosis of precancerous lesions in the upper GI tract. The status of deep learning algorithms in upper GI precancerous lesions has been systematically summarized. The challenges and recommendations targeting this field are comprehensively analyzed for future research.

show abstract

“…33 Smoking, drinking, and eating very hot food or beverages are high-risk environmental factors for ESCC. 34 Although there are few studies on ESD microenvironment, we can still find some valuable information about that. For example, it was reported that glucose transporter 1 (GLUT-1), an important glycolytic pathway enzyme, is highly expressed not only in ESCC tumor cells but also in tumor precursor cells.…”

Section: Esophageal Squamous Epithelium Dysplasia (Esd) Microenvironmentmentioning

confidence: 99%

<p>Esophageal Microenvironment: From Precursor Microenvironment to Premetastatic Niche</p>

Han¹,

Cao²,

Huang³

et al. 2020

CMAR

View full text Add to dashboard Cite

Esophageal cancer (EC) is the sixth most deadly cancer, and its incidence is still increasing year by year. Although the researches on the molecular mechanisms of EC have been widely carried out and incremental progress has been made, its overall survival rate is still low. There is cumulative evidence showing that the esophageal microenvironment plays a vital role in the development of EC. In precancerous lesions of the esophagus, high-risk environmental factors can promote the development of precancerous lesions by inducing the production of inflammatory factors and the recruitment of immune cells. In the tumor microenvironment, tumor-promoting cells can inhibit anti-tumor immunity and promote tumor progression through a variety of pathways, such as bone marrow-derived suppressor cells (MDSCs), tumor-associated fibroblasts (CAFs), and regulatory T cells (Tregs). The formation of extracellular hypoxia and acidic microenvironment and the change of extracellular matrix stiffness are also important factors affecting tumor progression and metastasis. Simultaneously, primary tumor-derived cytokines and bone marrow-derived immune cells can also promote the formation of pre-metastasis niche of EC lymph nodes, which are beneficial to EC lymph node metastasis. Further research on the specific mechanism of these processes in the occurrence, development, and metastasis of each EC subtype will support us to grasp the overall pre-cancerous prevention, targeted treatment, and metastatic assessment of EC.

show abstract

Oesophageal Squamous Dysplasia

Cited by 3 publications

References 24 publications

Management of Multifocal Squamous Dysplasia: Role of Esophagectomy

Management of Multifocal Squamous Dysplasia: Role of Esophagectomy

Deep learning for diagnosis of precancerous lesions in upper gastrointestinal endoscopy: A review

<p>Esophageal Microenvironment: From Precursor Microenvironment to Premetastatic Niche</p>

Contact Info

Product

Resources

About