Oestrogen-induced Fibroids of the Thoracic Serosa

Bruzzone, Silvio; Elgueta, H; Rodríguez, Iglesias; Lipschütz, Alexander

doi:10.1038/bjc.1948.31

Cited by 13 publications

(5 citation statements)

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“…The etiology of CGF is unknown, but several lines of evidence suggest a relationship to estrogenic hormones: 1) fibroblastic nodules morphologically identical to those seen in CGF can be produced within the uterus, the abdominal cavity,I6 and rarely the thoracic cavity" of guinea pigs treated with estrogens; 2) the lesions of CGF develop in ureru, and although they may continue to grow for a brief time after birth, they tend to regress once the fetus is removed from the intrauterine environment; 3) lymphangiomyomatosis, a disease almost exclusively of female patients of reproductive age, is characterized by proliferation of smooth muscle nodules in the walls of bronchioles, pulmonary venules, and lymphatics , 7 although the architectural arrangement and distribution of lesions within the lungs differ from that in CGF. A connection between estrogens and the fibromatoses is also suggested by the increased incidence of abdominal desmoids in pregnant women and of plantar fibromatosis in patients with liver disease.ls It may be that CGF is a developmental anomaly in which smooth muscle cells or cells with a potential No. 5 CONGENITAL FIBROMATOSIS * Roggli et ul.…”

Section: Discussionmentioning

confidence: 99%

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Congenital generalized fibromatosis with visceral involvement. A case report

Roggli

Kim

Hawkins

1980

Cancer

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A case of congenital generalized fibromatosis in a black male infant with involvement of lungs, subcutaneous tissue, pancreas, adrenal, lymph nodes, and bone is described. Fifteen prior cases with pulmonary involvement are reviewed, emphasizing the poor prognosis associated with pulmonary lesions. This case demonstrated, in addition to previously described histologic features, broad bands of fibroblastic proliferation in the interlobular septa producing retraction of the visceral pleura. Possible etiologic factors are discussed, with suggestions for additional studies in future cases.Cancer 45:954-960, 1980. ONGENITAL GENERALIZED FIBROMATOSIS (CGF)C is a rare entity,23 involving the formation of nodules or masses of well differentiated fibrous tissue in the viscera, musculoskeletal system, and subcutaneous tissue. In fatal cases, death occurs in the first few months of life.1,15*19 In those infants who survive, spontaneous regression of the masses has been described.1s*20,21,2s Pulmonary involvement in CGF seems to carry a particularly grave prognosis. Fifteen cases of fibromatosis involving the lungs have been ~e S c~~~e~, 2 ,~,~, R , 1 0 ' " 4 . ' " . ' " . 2 2 -2 4 , 2~, Z 7 and all but 2 patients died.x*19 We report a case of CGF with pulmonary involvement in a black infant. Case ReportA 4-month-old black boy was seen because of tachypnea and a one-week history of fever and anorexia. The infant, who weighed 1500 g at birth, was born to a primigravida woman after 35 weeks of gestation. Two purplish-red masses on the posterior aspect of the boy's head and the left side of the neck noted at birth were thought to be hemangiomas.Physical examination revealed that the infant was afebrile with a respiratory rate of 100 and pulse of 140imin. His weight, 4275 g, was below the 3rd percentile. The occipital mass had completely regressed, and the left cervical mass measured 5 x 5 x 1 cm. Right lower lobe rales, a Grade IIiVI systolic ejection murmur, and an S, gallop were noted on auscultation. Hepato-splenomegaly was present. Electrocardiographic studies demonstrated right axis deviation and right ventricular hypertrophy. The chest x-ray showed a n interstitial infiltrative process. The hemoglobin was 10.6 gidl, hematocrit 3296, white blood count 69001pL1, with 41% segmented neutrophils, 40% lymphocytes, 5% band neutrophils, and 14% monocytes. An open lung biopsy from the right upper lobe showed minimal interstitial mononuclear inflammation, mild intraalveolar edema, and Type I1 pneumonocyte hyperplasia. On the seventh postoperative day, the infant suffered a cardiac arrest and could not be resuscitated. Autopsy FindingsThe striking findings were in the respiratory and cardiovascular systems. The surface of the lungs was grossly nodular; the lungs were firm and noncrepitant. Some of the interlobular septa were prominently thickened by gray-white tissue, and small white spherical nodules, 1 mm or less in diameter, were occasionally noted in the parenchyma of the lung (Fig. 1). The heart was enlarged, with right ventricu...

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Section: Discussionmentioning

confidence: 99%

“…His weight, 4275 g, was below the 3rd percentile. The occipital mass had completely regressed, and the left cervical mass measured 5 x 5 x 1 cm. Right lower lobe rales, a Grade IIiVI systolic ejection murmur, and an S, gallop were noted on auscultation.…”

mentioning

confidence: 99%

Congenital generalized fibromatosis with visceral involvement. A case report

Roggli

Kim

Hawkins

1980

Cancer

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“…Further supporting evidence is the fact that saturable nuclear receptors for the sex steroids have been found in the major arteries, including the coronary circulation of subhuman primates, 27 and functional changes in arterial endothelium 28 and intimal proliferation have been observed in experimental animals treated with estrogen. 29 It seems likely that if contraceptive steroids have similar effects in humans, then their long-term administration in a continuous noncyclical mode and sustained interaction with cell receptors for native hormones could have important consequences on the arterial wall. While our data do not specify how these agents might influence atherogenesis in young women, our finding that serum from OC users has the capacity to consistently stimulate SMC growth above control levels suggests that long-term OC use may contribute to this component of lesion formation.…”

Section: Discussionmentioning

confidence: 99%

Atherosclerosis and oral contraceptive use. Serum from oral contraceptive users stimulates growth of arterial smooth muscle cells.

Bagdade

Subbaiah²

1982

Arteriosclerosis

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Pooled serum from women taking a combined estrogen-progestln oral contraceptive preparation caused significantly greater cell proliferation and Incorporation of 3 Hthymldine Into DNA In both human arterial smooth muscle cells and dermal flbroblasts In tissue culture than did serum from controls. A portion of this mitogenic effect appears to be related to the presence of a factor(s) that Is heat stable, nondialyzable, and contained in the lipoprotein-deficlent serum fraction. In vitro addition of varying concentrations of mestranol and norethlndrone, the two constituents of the oral contraceptive preparation taken by participants In the study, to control serum did not enhance Its mitogenlclty, suggesting that the effect observed with Intact serum was due either to a metabolite of these compounds or to the production of other growthpromoting substances during oral contraceptive treatment. Since smooth muscle cell proliferation Is an Integral feature of all atherosclerotic lesions, these findings provide some Insights applicable to understanding the pathogenesls of vascular disease associated with oral contraceptive use. E pidemiological studies indicate that the use of oral contraceptives (OC) threatens the immunity to coronary heart disease (CHD) that females have enjoyed. It now appears that when healthy young women use these potent contraceptive steroids, their previously negligible risk of heart attack increases fourfold, 1 " 3 and the risk of both CHD and stroke 4 rises geometrically in the presence of other risk factors such as cigarette smoking, hypertension, and hypercholesterolemia.5 While precisely how constituents of these preparations influence the pathogenesis of vascular disease in OC users is not known, there is evidence suggesting that they may accelerate atherogenesis. In one autopsy study, extensive degrees of arterial smooth muscle cell (SMC) proliferation and intimal deposition of lipid and

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“…Ces constatations expérimentales [3,20], doublées par celles de la cli nique -augmentation de l'incidence chez la femme et en particulier durant l'activité génitale; rémissions spontanées après la ménopause [27] et pendant la grossesse [4] -plaident en faveur d'une hormonodépendance des TD. Ce pendant, la TD que présentait notre patiente en février 1978 ne contenait pas de récepteurs hormonaux ni pour l'oestradiol ni pour la progestérone.…”

Section: Discussionunclassified

Fibrome desmoïde – Transformation en fibrosarcome

Lowy¹,

Lejeune²,

Heimann³

et al. 1981

Dermatology

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Report of a case of aggressive musculo-aponeurotic fibromatosis in a 14-year-old girl with transformation into fibrosarcoma, 10 years later. The tumoral mass initiated its growth in the nucal region but finally invaded both the cervical and the right retroscapular region. Evidence for muscular, osseous and neurological invasion and destruction was found. The tumor could be controlled neither by surgery, nor by radiotherapy and chimiotherapy. This case report is studied in the light of cases reported in the literature.

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Oestrogen-induced Fibroids of the Thoracic Serosa

Cited by 13 publications

References 0 publications

Congenital generalized fibromatosis with visceral involvement. A case report

Congenital generalized fibromatosis with visceral involvement. A case report

Atherosclerosis and oral contraceptive use. Serum from oral contraceptive users stimulates growth of arterial smooth muscle cells.

Fibrome desmoïde – Transformation en fibrosarcome

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