Oestrogen receptor genotypes and litter size in Hungarian Large White pigs

Horogh, G.; Zsolnai, Attila; Komlósi, István; Nyíri, A.; Anton, István; Fésüs, László

doi:10.1111/j.1439-0388.2004.00483.x

Cited by 19 publications

(6 citation statements)

References 15 publications

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“…A paradigmatic case is the estrogen receptor 1 (ESR1), proposed as a major gene for prolificacy in 1996 by Rothschild et al [24]. The reported association between a polymorphic PvuII restriction site in the ESR1 gene and litter size has been supported by subsequent studies [8,27,28], whereas no statistical association between this single nucleotide polymorphism (SNP) and prolificacy was detected in other populations [5,6,20]. A meta-analysis of 15 published association studies outlined the high and significant heterogeneity of the ESR1 PvuII polymorphism effects estimated among studies performed in diverse pig populations [1].…”

Section: Introductionmentioning

confidence: 99%

Association with litter size of new polymorphisms on ESR1 and ESR2 genes in a Chinese-European pig line

Muñoz¹,

Óvilo²,

Estellé³

et al. 2007

Genet Sel Evol

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Section: Introductionmentioning

confidence: 99%

Association with litter size of new polymorphisms on ESR1 and ESR2 genes in a Chinese-European pig line

Muñoz¹,

Óvilo²,

Estellé³

et al. 2007

Genet Sel Evol

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“…One marker, which is used in commercial pig production, is the estrogen receptor gene 1 (ESR1), and ROTHSCHILD et al (1996) were the first who observed an association between ESR1 genotypes and litter size in swine. However, so far, there are a lot of inconsistent studies with regard to influence on the ESR1 gene on fecundity parameters in swine (SHORT et al, 1997;DEPUYDT et al, 1999;DRÖGEMÜLLER et al, 1999;KMIEĆ et al, 2002;GIBSON et al, 2002; VAN RENS and VAN DER LENDE, 2002;MATOUŠEK et al, 2003;GOLIÁŠOVÁ and WOLF, 2004;HORÁK et al, 2005;HOROGH et al, 2005;WANG et al, 2006). Therefore, additional candidate genes with potential influence on litter size are studied.…”

Section: Introductionmentioning

confidence: 99%

Analysis of association of GPX5, FUT1 and ESR2 genotypes with litter size in a commercial pig cross population

et al. 2006

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The aim of this study was to investigate, if special genotypes of the genes glutathione peroxidase 5 (GPX5), fucosyltransferase 1 (FUT1) and estrogen receptor 2 (ESR2) are associated with litter size in a commercial pig cross population. For this purpose, a total of 123 F 2 sows were divided into two extreme performance groups, one with a high litter size (n = 61, ≥ 14.3 piglets per litter) and one with a low litter size (n = 62, ≤ 11.3 piglets per litter) and genotyped using PCR-RFLP methods. The Chi-square test was used in order to investigate, if a special genotype occurs significantly more often in one of the two performance groups (p < 0.05). Whereas no association was found between different ESR2 or GPX5 genotypes with one of the two performance groups, the number of sows with AB genotypes at the FUT1 gene was significantly increased in the high performance group in comparison to the low performance group.

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“…Inconsistencies about the effects of the two alleles of ESR1 gene have been reported in the literature (reviewed by Alfonso, 2005;Buske et al, 2006a;Distl, 2007). The positive effect of allele B on total number born (TNB) or NBA was identified in synthetic lines and in European breeds (Southwood et al, 1995;Rothschild et al, 1996;Short et al, 1997;Chen et al, 2000;Horogh et al, 2005). However, a favorable effect of allele A on NBA was observed in Large White pigs (Van Rens et al, 2002;Goliasova and Wolf, 2004;Santana et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

ESR1andESR2gene markers are not associated with number of piglets born alive in Italian Large White sows

Dall’Olio

Tognazzi

Buttazzoni

et al. 2011

Italian Journal of Animal Science

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Many studies have reported that markers in the estrogen receptor 1 (ESR1) and estrogen receptor 2 (ESR2) genes are associated with litter size in pigs, even if inconsistent results have been obtained in different populations. We analysed the ESR1 PvuII and the ESR2 AF164957:c.949G>A polymorphisms in Italian Large White (ITLW) sows to evaluate if these markers are associated with number of piglets born alive at first litter (NBA1). First, both polymorphisms were genotyped by selective genotyping in a total of 440 sows chosen according to the extreme and divergent estimated breeding value (EBV) for NBA1 (220 sows with low EBV and 220 sows with high EBV). For the ESR1 polymorphism, no allele and genotype frequency differences were observed between the two groups (allele A=0.62 and allele B=0.38 in both two groups). For the ESR2 polymorphism, a trend of different allele frequency between the two tails was identified (P=0.052). However, no significant association between the same ESR2 marker and EBV NBA1 was detected analyzing 1772 ITLW sows (allele A=0.59 and allele G=0.41). As the two investigated polymorphisms were not associated with NBA1 EBVs, they seem not useful for marker assisted selection to improve this trait in the ITLW breed.

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Oestrogen receptor genotypes and litter size in Hungarian Large White pigs

Cited by 19 publications

References 15 publications

Association with litter size of new polymorphisms on ESR1 and ESR2 genes in a Chinese-European pig line

Association with litter size of new polymorphisms on ESR1 and ESR2 genes in a Chinese-European pig line

Analysis of association of GPX5, FUT1 and ESR2 genotypes with litter size in a commercial pig cross population

ESR1andESR2gene markers are not associated with number of piglets born alive in Italian Large White sows

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