Oestrogenic and Anti-Oestrogenic Activity of Androgens in the Ewe

Lindsay, D. R.; Robinson, T. J.

doi:10.1530/jrf.0.0070267

Cited by 11 publications

(4 citation statements)

References 9 publications

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“…The augmentation of oestrogen-induced behavioural oestrus by androstenedione is similar to that by testosterone, in that vaginal oestrus is also inhibited (Lindsay & Robinson, 1964). Its behavioural effect may be due to a direct action on reacting neurones or to pro-oestrogenic activity after conversion to oestrogen or testosterone.…”

Section: Resultsmentioning

confidence: 75%

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Oestrogenic and Antioestrogenic Activities of a Number of Steroids in Behavioural Oestrus and Vaginal Smear Assays in the Ewe

Lindsay¹,

Scaramuzzi²

1969

Journal of Endocrinology

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Fourteen synthetic steroids and androstenedione were examined in ovariectomized ewes for oestrogenic activity when administered alone and with oestradiol benzoate by intramuscular injection. None of the compounds investigated was active when administered alone, as assessed by the vaginal smear assay, and only androstenedione produced a behavioural response.Androstenedione had a MED of 8\m=.\8 mg. but was less active when administered intravenously. Several steroids acted as anti-oestrogens when injected with oestradiol benzoate. Eight steroids inhibited the behavioural response and four the vaginal response. An additive response was found with androstenedione for behavioural response and with 17\g=b\-ethyl -17\x=req-\ hydroxy-19-nor-4-androsten-3-one (SC-5914) for vaginal response.Vaginal and behavioural responses were not necessarily related, and responses obtained in the ewe to particular steroids were not identical with those obtained in laboratory animals by other workers using similar tests.

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Section: Resultsmentioning

confidence: 75%

“…Testosterone given with oestrogen to progesterone-primed ovariectomized ewes has a dual action (Lindsay & Robinson, 1964). Oestrogen-induced behavioural oestrus is augmented by the testosterone but the normal vaginal smear response (Robinson & Moore, 1956) is virtually eliminated.…”

Section: Introductionmentioning

confidence: 99%

Oestrogenic and Antioestrogenic Activities of a Number of Steroids in Behavioural Oestrus and Vaginal Smear Assays in the Ewe

Lindsay¹,

Scaramuzzi²

1969

Journal of Endocrinology

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“…Current thinking is that androgen can be aromatized to oestrogen but, if so, only the neural receptor sites have this capacity; peripheral sites do not. Interestingly, further studies showed that oestrogen and androgen were additive in their effect on behaviour but antagonistic on the vaginal response (Lindsay & Robinson, 1961a& Robinson, , 1964).…”

Section: Eps Ementioning

confidence: 99%

“…First of all, the progesterone-oestrogen interaction on oestrous behaviour and vaginal changes had been worked out in detail (see Robinson, 1959). Secondly, it had been shown that the behavioural and peripheral components of oestrus were not necessarily dependent (Lindsay & Robinson, 1961a& Robinson, , 1964. Thirdly, the myth of rams detecting ewes in oestrus had been exploded; oestrous ewes either find their mates or permit themselves to be found (Inkster, 1957; Lindsay & Robinson, 1961b).…”

Section: Eps Ementioning

confidence: 99%

Hammond Memorial Lecture

Robinson¹

1982

Reproduction

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John Hammond died 16 years ago, and there are many of the younger generation to whom he is just a name. He became a legend in his time and his influence was enormous. He drew students from all over the world and these came to occupy key positions in animal science in many countries (Pl. 1, Fig. 1). We are a dying generation, but many of us have produced our own postgraduate students to whom some of the Hammondian philosophy has been transmitted, and they in turn are now producing their students. The title of this address was suggested by a remark made to me many years ago by Professor 'Bunny' Austin. At an SSF meeting, I forget when or where, a group of us were talking about postgraduate training, and I remarked on the seeming casualness of Hammond. Practically all my discussions with him took place on Sunday over tea at Luard Road, and it seemed that he always left the next day for Argentina or some such place. As for my programme, he never interfered; he merely advised, guided and encouraged. He was not interested in teaching techniques-other than carcase dissection which I soon learned to avoid like the plague. But he knew who had the techniques and he passed this on-his son, John, at the Strangeways for ovum culture, Idwal Rowlands at Tunbridge Wells for information about PMSG, Wishart and Fisher for statistics, Pike for histology and Gordon Pluck for animal techniques. The esteem in which Hammond was held by all his students was well known and this seeming casualness excited Bunny Austin to exclaim, "Well, what was the magic of Hammond?". I don't think I answered at the time and this is a belated attempt to do so, based upon an account of his tremendous influence on me personally, on my work, and on that of my students. I first met Hammond in 1938 when he came to Australia to advise the Government of the day about increasing meat exports to the United Kingdom. He visited the University of Western Australia and gave two lectures to the senior students of Agriculture, one on growth and development of meat qualities and one on reproduction. The impact on me was immense. I recognized that I was in the presence of a great man and I made up my mind, then and there, that I would work with that man. Well, the war intervened and 9 years were to pass before I found myself, in July 1947, on H deck of RMS Orion working my passage to Tilbury Docks as an Acting Temporary Steward, 3rd class on probation. And if any postgraduate student thinks that he or she is at the bottom of the barrel, try signing on as an Acting Temporary Steward, 3rd Class on probation! In the meantime, two important things had happened on the agricultural front in Western Australia. First of all, the increased interest in lamb production for the English market had resulted in a switch from the Merino, with its capacity to breed at any month of the year, to the Border Leicester Merino ewe with a restricted breeding season which was not geared to our Mediterranean type climate. Out-of-season breeding became an issue. Secondly, infertility of ewes graze...

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Chemische Konstitution und pharmakologische Wirkung

Neumann¹

1968

Die Gestagene

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Oestrogenic and Anti-Oestrogenic Activity of Androgens in the Ewe

Cited by 11 publications

References 9 publications

Oestrogenic and Antioestrogenic Activities of a Number of Steroids in Behavioural Oestrus and Vaginal Smear Assays in the Ewe

Oestrogenic and Antioestrogenic Activities of a Number of Steroids in Behavioural Oestrus and Vaginal Smear Assays in the Ewe

Hammond Memorial Lecture

Chemische Konstitution und pharmakologische Wirkung

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