Of chronic diazepam treatments on behavior on individually housed rats

Spasojević, Nataša; Gavrilović, Ljubica; Varagic, V; Dronjak, Sladjana

doi:10.2298/abs0702113s

Cited by 21 publications

(6 citation statements)

References 22 publications

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“…The standard drug diazepam controlled the metabolic alterations and gastric ulcers in CMS rats indicate the GABAergic role in CMS induced physiological alterations. Earlier reports indicated that diazepam reversed the stress induced non-grooming and grooming behaviour and gastric ulcers in rats [ 33 , 34 ] which supports our present findings. Further, diazepam reversed the CMS induced behavioural alterations and showed anxiolytic activity in open field test, antidepressant activity in behavioural despair test.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of behavioural and antioxidant activity of Cytisus scoparius Link in rats exposed to chronic unpredictable mild stress

Nirmal

Babu

Harisudhan

et al. 2008

BMC Complement Altern Med

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Background: Various human diseases have oxidative stress as one of their component. Many herbs have been reported to exhibit properties that combat oxidative stress through their active constituents such as flavonoids, tannins, phenolic compounds etc. Cytisus scoparius (CS) Link, (Family: Leguminosae), also called Sarothamnus scoparius, has been shown in invitro experiments to be endowed with anti-diabetic, hypnotic and sedative and antioxidant activity. Therefore this study was carried out to evaluate CS for its anxiolytic, antidepressant and anti-oxidant activity in stressed rats.

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Section: Discussionsupporting

confidence: 93%

Evaluation of behavioural and antioxidant activity of Cytisus scoparius Link in rats exposed to chronic unpredictable mild stress

Nirmal

Babu

Harisudhan

et al. 2008

BMC Complement Altern Med

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“…Our results agree with several social isolation studies that reported: anxiety-like behaviour after isolation in early stages of development [45,[48][49][50][51][52][53][54], in adolescence [55][56][57], and also -but less described-in adulthood [22,47]. Moreover, chronic adult isolation reduced the duration of grooming and caused more urination and defecation [58]. Social deprivation is a potent emotional stressor, and it can alter the correct functioning of the immune and neuroendocrine systems [7].…”

Section: Discussionsupporting

confidence: 91%

Adult social isolation leads to anxiety and spatial memory impairment: Brain activity pattern of COx and c-Fos

Zorzo

Méndez-López

Méndez

et al. 2019

Behavioural Brain Research

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Social isolation during adulthood is a frequent problem that leads to a large variety of adverse emotional and cognitive effects. However, most of the social isolation rodent procedures begin the separation early post-weaning. This work explores locomotor activity, anxiety-like behaviour, and spatial working memory after twelve weeks of adult social isolation. In order to study the functional contribution of selected brain areas following a working memory task, we assessed neuronal metabolic activity through quantitative cytochrome oxidase histochemistry and c-Fos immunohistochemistry. Behaviourally, we found that isolated animals (IS) showed anxiety-like behaviour and worse working memory than controls, whereas motor functions were preserved. Moreover, IS rats showed lower levels of learning-related c-Fos immunoreactivity, compared to controls, in the medial prefrontal cortex (mPFC), ventral tegmental area (VTA), and nucleus accumbens shell. In addition, the IS group showed lower neuronal metabolic activity in the mPFC, VTA, and CA1 subfield of the hippocampus. These results indicate that twelve weeks of social isolation in adult rats leads to different behavioural and brain alterations, and they highlight the importance of social support, not only in development, but also in adulthood.

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“…The fact that chronic isolation did not affect locomotor activity or grooming could perhaps be explained by the duration of stress which lasted for only 3 weeks. Some other authors reported that longer periods of isolation could result in hyperlocomotion [33] as well as in altered quality (order and duration of single sequences), but not frequency, of grooming [34]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Chronic Social Isolation on Wistar Rat Behavior and Brain Plasticity Markers

Djordjević¹,

Djordjević²,

Adžić³

et al. 2012

Neuropsychobiology

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Chronic stress is a contributing risk factor in the development of psychiatric illnesses, including depressive disorders. The mechanisms of their psychopathology are multifaceted and include, besides others, alterations in the brain plasticity. Previously, we investigated the effects of chronic social stress in the limbic brain structures of Wistar rats (hippocampus, HIPPO, and prefrontal cortex, PFC) and found multiple characteristics that resembled alterations described in some clinical studies of depression. We extended our investigations and followed the behavior of stressed animals by the open field test (OFT) and forced swimming test (FST), and the expression and polysialylation of synaptic plasticity markers, neural cell adhesion molecule (NCAM) and L1, in the HIPPO and PFC. We also determined the adrenal gland mass and plasma corticosterone (CORT) as a terminal part of the hypothalamic-pituitary-adrenal axis activity. Our data indicated that stressed animals avoided the central zone in the OFT and displayed decreased swimming, but prolonged immobility in the FST. The animals exhibited marked hypertrophy of the adrenal gland cortex, in spite of decreased serum CORT. Simultaneously, the stressed animals exhibited an increase in NCAM mRNA expression in the HIPPO, but not in the PFC. The synaptosomal NCAM of the HIPPO was markedly polysialylated, while cortical PSA-NCAM was significantly decreased. The results showed that chronic social isolation of Wistar rats causes both anxiety-like and depression-like behavior. These alterations are parallel with molecular changes in the limbic brain, including diminished NCAM sialylation in the PFC. Together with our previous results, the current observations suggest that a chronic social isolation model may potentially be used to study molecular mechanisms that underlie depressive symptomatology.

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Of chronic diazepam treatments on behavior on individually housed rats

Cited by 21 publications

References 22 publications

Evaluation of behavioural and antioxidant activity of Cytisus scoparius Link in rats exposed to chronic unpredictable mild stress

Evaluation of behavioural and antioxidant activity of Cytisus scoparius Link in rats exposed to chronic unpredictable mild stress

Adult social isolation leads to anxiety and spatial memory impairment: Brain activity pattern of COx and c-Fos

Effects of Chronic Social Isolation on Wistar Rat Behavior and Brain Plasticity Markers

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