Of the in vivo behavior of calcium phosphate cements and glasses as bone substitutes

Sanzana, Edgardo S.; Navarro, Melba; Macule, F.; Suso, S.; Planell, Josep A.; Ginebra, Maria‐Pau

doi:10.1016/j.actbio.2008.04.023

Cited by 68 publications

(55 citation statements)

References 24 publications

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“…The values observed at day 7 suggest that the mere presence of particles of these products filling the cavities already yields higher density values in relation to the natural process of bone regeneration, as reported by Välimäki et al 6 and Sanzana et al 7 This phenomenon demonstrates the important role that the biomaterials studied play as scaffolds for bone healing and new bone formation, since they are replaced with bone tissue over time, through a phenomenon known as osteotransduction 8 . At the same time, they promote faster bone regeneration due to their osteoconductive and osteoinductive properties 3 , through which the biomaterials seemed to induce the process of bone repair and new bone formation earlier than in the control group.…”

Section: Discussionsupporting

confidence: 57%

Evaluation of optical density of bone defects filled with calcium phosphate cement and bioactive glass in rats

et al. 2011

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Purpose: To evaluate new bone formation, by the analysis of optical density, in rat femoral defects filled with calcium phosphate cement (CPC) and bioactive glass (BG). Methods: Twenty-one rats were divided into three groups, Group I (CPC), Group II (BG), and Group III (control), and assessed after 7, 15, and 30 days. Three bone cavities were made in the left femur and filled with CPC, BG, and no material (control). Digital images were obtained and the results were subjected to statistical analysis of variance (ANOVA), complemented by the Friedman and Kruskal-Wallis nonparametric tests, with a significance level of 5%. Results: Regarding optical density, Group I showed statistical values significantly higher than Group III and also higher, although not statistically significant, than Group II, in all observation periods. When Groups II and III were compared, Group II showed higher optical density values, without statistically significant differences, in all periods. Conclusion: The biomaterials analyzed showed higher optical density in relation to the control group in all observation periods, calcium phosphate cement being the best option in the repair of bone defects, but without statistically significant differences in relation to bioactive glass.

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Section: Discussionsupporting

confidence: 57%

Evaluation of optical density of bone defects filled with calcium phosphate cement and bioactive glass in rats

et al. 2011

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“…Evidences of the direct contact of bone and a calcium orthophosphate cement without soft tissue interposition might be found in literature [365,366]. Different studies reported on both cement bioresorption and the progress of bone formation around calcium orthophosphate cements which in certain cases demonstrated both osteoconductive and osteoinductive properties [367]. However, there are studies in which the osteoinductive properties of calcium orthophosphate cements were not confirmed [368].…”

Section: Bioresorption and Replacement Of The Self-setting Formulatiomentioning

confidence: 96%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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“…However, based on the authors' experience using other glass systems, a glass preform temperature _40 K lower than the onset furnace temper-ature should be expected. Basically, considering the drawing tem-peratures reported in Section 2.3, the temperature of the preform was _545 LC for TiPS 0 , 580 LC for TiPS 2.5 and 650 LC for TiPS 5 , which are below the respective T c of the glasses (552 LC, 640 LC and 687 LC [22]). As it is possible to observe in Fig.…”

Section: Glass Fibresmentioning

confidence: 99%

“…The solubility of phosphate glasses and the possibility of producing them in bulk, powder, porous scaf-fold or flexible fibre forms make them suitable for the design of resorbable biomedical devices for both hard and soft tissue regen-eration [3]. These glasses have been studied for bone tissue regen-eration in powder and porous scaffold forms or in composite materials [4][5][6][7][8][9], for application in the hard-soft tissue interface such as the ligament-tendon/bone attachment defects [10][11][12]. In addition, resorbable and flexible phosphate glass fibres are attractive materials for soft tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Phosphate glass fibres and their role in neuronal polarization and axonal growth direction

et al. 2012

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Of the in vivo behavior of calcium phosphate cements and glasses as bone substitutes

Cited by 68 publications

References 24 publications

Evaluation of optical density of bone defects filled with calcium phosphate cement and bioactive glass in rats

Evaluation of optical density of bone defects filled with calcium phosphate cement and bioactive glass in rats

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Phosphate glass fibres and their role in neuronal polarization and axonal growth direction

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