Offspring outcomes after prenatal interventions for common mental disorders: a meta-analysis

Brouwer, Marlies; Williams, Alishia D.; Grinsven, Sam E. van; Cuijpers, Pim; Berg, Mijke P. Lambregtse–van den; Burger, Huibert; Bockting, Claudi

doi:10.1186/s12916-018-1192-6

Cited by 14 publications

(9 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8 Studies in the literature report that high levels of stress in pregnant women cause many untoward consequences including preeclampsia, preterm births, stillbirths, and low Apgar scores. [9][10][11] Getting quite out of hand and turning into a pandemic shortly; COVID-19 causes despair and hopelessness in pregnant women, as well as other individuals in society. COVID-19 has led pregnant women to implement meticulous personal hygiene habits and take more serious measures such as social restraint and isolation against infection.…”

Section: Introductionmentioning

confidence: 99%

The level of depression, anxiety, and sleep quality in pregnancy during coronavirus disease 2019 pandemic

Çolak

Gürlek

Önal

et al. 2021

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Aim: We aimed to evaluate the mental health and sleep quality of pregnant women in different trimesters during coronavirus disease 2019 (COVID-19) pandemic and investigate the effect of quarantine and new lifestyle changes that come into our lives with pandemic with on this subject. Methods: It was conducted on pregnant women (n = 149) who attended routine pregnancy prenatal visit during their pregnancy weeks. The data were collected using sociodemographic and clinical data form, Pittsburgh Sleep Quality Index (PSQI) to evaluate sleep quality, Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) to evaluate maternal depression and anxiety. Results: A significant correlation was observed between the week of gestation and depression, anxiety, and defective sleep scores (p < 0.001). A moderate positive correlation was found between the week of gestation and depression (r: 0.628). A high level of positive correlation was found between the week of gestation and defective sleep quality and anxiety scores (r: 0.858, r: 0.754). A statistically significant increase in depression, anxiety, and defective sleep quality was found in the group staying in home quarantine (p = 0.002). Conclusion:This study showed that the COVID-19 pandemic can cause depression, anxiety, and serious sleep disorders in pregnant women. The depression and anxiety scores of pregnant women in home quarantine were also found to be higher than the group not in quarantine. As the week of gestation progresses, mental health symptoms worsen and sleep quality deteriorates.

show abstract

Section: Introductionmentioning

confidence: 99%

The level of depression, anxiety, and sleep quality in pregnancy during coronavirus disease 2019 pandemic

Çolak

Gürlek

Önal

et al. 2021

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…On the other hand, psychotherapy may likewise positively or negatively influence birth weight. A recent meta-analysis found that birth weight could be negatively or positively affected when pregnant women with common mental disorders received psychotherapy, depending on the disorder and type of treatment (16). The absence of a direct influence of affect fluctuations on birth weight does not necessarily mean that these fluctuations do not affect the offspring.…”

Section: Discussionmentioning

confidence: 99%

“…Birthweight and gestational age can hence be perceived as first indications of infant's future (mental) health. It is presumed that psychological and pharmacological treatment of pre-natal common mental disorders can mitigate associated adverse effects in offspring, yet strong evidence for the prophylactic benefits of (preventive) treatment is limited (16,17).…”

Section: Introductionmentioning

confidence: 99%

Tapering Antidepressants While Receiving Digital Preventive Cognitive Therapy During Pregnancy: An Experience Sampling Methodology Trial

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Previous studies indicated that affect fluctuations, the use of antidepressant medication (ADM), as well as depression during pregnancy might have adverse effects on offspring outcomes. The aim of the current proof-of-principle study is to explore the effect of tapering ADM while receiving online preventive cognitive therapy (PCT) on pregnant women and the offspring as compared to pregnant women continuing ADM. Objectives: We sought to compare positive and negative affect fluctuations in pregnant women receiving online PCT while tapering ADM vs. pregnant women continuing ADM, and to investigate if affect fluctuations in early pregnancy were related to offspring birth weight. Method: An experience sampling methodology (ESM)-trial ran alongside a Dutch randomized controlled trial (RCT) and prospective observational cohort of women using ADM at the start of pregnancy. In the ESM-trial fluctuations of positive and negative affect were assessed in the first 8 weeks after inclusion. Recurrences of depression were assessed up to 12 weeks post-partum, and birth records were used to assess offspring birth weight. The RCT has been registered at the Netherlands Trial Register (NTR4694, https://www.trialregister.nl/trial/4551). Results: In total, 19 pregnant women using ADM at start of their pregnancy participated in the ESM-trial. There were no significant differences in positive and negative affect fluctuations, nor recurrence rates between women receiving PCT while tapering ADM vs. women continuing ADM. We found no association between affect fluctuations, pre-natal depressive symptoms, and birth weight (all p > 0.05). Conclusion: This explorative study showed that tapering ADM while receiving online PCT may protect pregnant women against recurrences of depression and affect fluctuations, without affecting birth weight. There is a high need for more controlled studies focusing on tapering ADM with (online) psychological interventions during pregnancy.

show abstract

“…No effect of discontinuation on risk of recurrence was observed, however, the proportion of women discontinuing medication was small and results should therefore be interpreted with caution. Future studies should aim to define additional predictors for recurrence of depression in pregnancy, assess the effects of implementing screening instruments during this phase, and to evaluate the effect of treatments in the perinatal period in order to benefit women and (potentially) their offspring [26, 46].…”

Section: Discussionmentioning

confidence: 99%

Recurrence of depression in the perinatal period: Clinical features and associated vulnerability markers in an observational cohort

et al. 2019

Self Cite

View full text Add to dashboard Cite

Objective Antidepressant medication is commonly used for the prevention of depression recurrence in the perinatal period, yet it is unknown what vulnerability markers may play a role in recurrence. The objective of the current study was to provide a descriptive overview of the associated characteristics of women who experienced a perinatal recurrence of depression despite ongoing antidepressant use, and further, to identify clinically measurable vulnerability markers associated with recurrence. Methods Eighty-five pregnant women with a history of depression who used antidepressants (e.g. Selective Serotonin Reuptake Inhibitors or Serotonin and Noradrenaline Reuptake Inhibitors) at the start of the study were included. Clinical features, including information on psychiatric history and antidepressant use, were collected throughout the perinatal period (in this study defined as the period between 12 weeks of pregnancy untill three months postpartum). The clinical features of women experiencing recurrence of depression were described in detail. To identify vulnerability markers associated with recurrence of depression, we performed exploratory univariable logistic regression analyses. Results Eight women (9.4%) experienced a recurrence of depression; two during pregnancy and six in the first 12 weeks postpartum. All women with recurrence of depression had first onset of depression during childhood or adolescence and had at least 2 psychiatric co-morbidities. Identification of vulnerability markers associated with recurrence of depression yielded associations with depressive symptoms around 16 weeks of pregnancy (OR 1.28, 95%CI 1.08–1.52), number of psychiatric co-morbidities (OR 1.89, 95%CI 1.16–3.09) and duration of antidepressant use (OR 1.01, 95%CI 1.00–1.02). Conclusion Implementing adequate risk assessment in pregnant women who use antidepressants can help identify predictors for recurrence of depression in future studies and thus ultimately lead to improved care.

show abstract

Offspring outcomes after prenatal interventions for common mental disorders: a meta-analysis

Cited by 14 publications

References 55 publications

The level of depression, anxiety, and sleep quality in pregnancy during coronavirus disease 2019 pandemic

The level of depression, anxiety, and sleep quality in pregnancy during coronavirus disease 2019 pandemic

Tapering Antidepressants While Receiving Digital Preventive Cognitive Therapy During Pregnancy: An Experience Sampling Methodology Trial

Recurrence of depression in the perinatal period: Clinical features and associated vulnerability markers in an observational cohort

Contact Info

Product

Resources

About